Search results for "Toll"
showing 10 items of 324 documents
Distinct bhaplotype structure at the innate immune receptor Toll-like receptor 2 across bank vole populations and lineages in Europe
2015
Abstract: Parasite-mediated selection may contribute to the maintenance of genetic variation at host immune genes over long time scales. To date, the best evidence for the long-term maintenance of immunogenetic variation in natural populations comes from studies on the major histocompatibility complex (MHC) genes, whereas evidence for such processes from other immune genes remains scarce. In the present study, we show that, despite pronounced population differentiation and the occurrence of numerous private alleles within populations, the innate immune gene Toll-like receptor 2 (TLR2) displays a distinct haplotype structure in 21 bank vole (Myodes glareolus) populations across Europe. Haplo…
Role of genetic polymorphisms in myocardial infarction at young age
2010
Acute myocardial infarction (AMI) in young adult presents a typical pattern of risk factors, clinical, angiographic and prognostic characteristics. In the last years we demonstrated that hemorheological profile is altered in these patients in a persistent way and independently of the number of risk factors and of the extent of coronary lesions. Thus, the hyperviscosity syndrome following AMI could be considered an intrinsic characteristic of these patients. Consequently it is possible to hypothesise the presence of a genetic background at the origin of this predisposition. If this background is able to influence the risk of ischemic heart disease, this should be particularly evident in youn…
Cigarette smoke increases TLR4 and modifies LPS mediated responses in airway epithelial cells.
2008
Airway epithelium is emerging as a regulator of innate immune responses to a variety of insults including cigarette smoke. The main goal of this study was to explore the effects of cigarette smoke extracts (CSE) on Tolllike receptor (TLR) expression and activation in a human bronchial epithelial cell line (16-HBE). The CSE increased the expression of TLR4 and the lipopolysaccharide (LPS) binding, the nuclear factor-jB (NF-jB) activation, the release of interleukin-8 (IL-8) and the chemotactic activity toward neutrophils. It did not induce TLR2 expression or extracellular signal-regulated signal kinase 1/2 (ERK1/2) activation. The LPS increased the expression of TLR4 and induced both NF-jB a…
Desenvolupament i dret econòmic
2012
Xerrada sobre la llei econòmica donada en el congrés sobre lleis regionals i internacionals realitzat a València del 13 al 15 de setembre.
Molecular mechanisms of cytoplasmic polyadenylation in drosophila
2012
Drosophila early embryogenesis is an ideal system to study control of gene expression at the post transcriptional level, since at this stage there is little or no transcription. This first section gives a brief overview on early development in Drosophila. Since in this thesis, toll, a maternal mRNA implicated in the establishment of the dorso-ventral axis during early stages of embryonic development, is used as a model to uncover the molecular mechanism of cytoplasmic polyadenylation at this developmental stage.
Indigon sinisestä kokenillin punaiseen : tekstiilivärjäyksessä käytettyjen luonnonväriaineiden tuonti Suomeen (1791–1856)
2022
Tutkimme ulkomaisten luonnonväriaineiden tuontia Suomeen 1790-luvun alusta 1850-luvun puoliväliin. Ajankohtaa voidaan luonnehtia murroskaudeksi väriaineiden käytön historiassa. Selvitämme mitä väriaineita Suomeen tuotiin, millaisia määriä, minneniitä tuotiin sekä mistä satamista väriainelastit olivat lähtöisin. Lähdeaineistomme perustan muodostavat Tanskan Juutinrauman tullitilit, joista on koostettu suomalaisia satamia koskeva tietokanta (FIN-STRO: 1560/1791–1856). Lähdepohjaa on täydennetty muulla tilastoaineistolla sekä laadullisella materiaalilla, kuten värjäysoppailla ja Kansalliskirjaston digitaalisella sanomalehtiarkistolla. Tutkimme erityisesti sinistä, punaista ja keltaista väriä t…
UNEDF-parametrisaatioiden ennustamien sidosenergioiden tilastolliset virheet
2015
Tämän pro gradu -tutkielman tavoitteena oli tutkia UNEDF0, UNEDF1 ja UNEDF2-parametrisaatioiden ennustamia sidosenergioita ja näiden tilastollisia virheitä eri ytimille HFBTHO-tietokone-ohjelmaa käyttäen. Tilastollisena virheenä käytin keskihajontaa. Tarkasteltavana olivat parillis-parilliset Gd-ytimet (A=130−180), parillis-parilliset Dy-ytimet (A=140−182) sekä UNEDF1- ja UNEDF2-parametrisaatioissa parametrien sovitukseen käytetyt ytimien U-226, U-238, Pu-240 ja Cm-242 fissioisomeerit. Vertasin laskennallisia sidosenergioita ja näiden virheitä niin toisiinsa kuin kokeellisesti määritettyihin arvoihin. Lisäksi tutkin, mitkä käytettyjen mallien parametreista ovat eniten vastuussa tilastollise…
LACOSAMIDE: TERAPIA IN ADD ON NEL TRATTAMENTO DELL’EPILESSIA PARZIALE
2012
Razionale ed obiettivi: La lacosamide è una nuova molecola con spiccata attività anticonvulsivante utilizzata nelle forme di epilessia ad esordio focale. Obiettivo del nostro studio è quello di valutare la tollerabilità, le interazioni farmacologiche e l’efficacia di questo nuovo farmaco usato in associazione ai vecchi ed ai nuovi farmaci antiepilettici. Pazienti e metodi: Abbiamo arruolato 30 pazienti afferenti al nostro Centro per la Diagnosi e la Cura dell’Epilessia dell’Università degli studi di Palermo affetti da epilessia parziale in bi-politerapia. L’età media dei pazienti era di 36,6 anni, l’età media di esordio della prima crisi di 15,9; 25 erano farmacoresistenti e 22 hanno presen…
Predicting the age at natural menopause in middle-aged women
2021
Objective To predict the age at natural menopause (ANM). Methods Cox models with time-dependent covariates were utilized for ANM prediction using longitudinal data from 47 to 55-year-old women (n = 279) participating in the Estrogenic Regulation of Muscle Apoptosis study. The ANM was assessed retrospectively for 105 women using bleeding diaries. The predictors were chosen from the set of 32 covariates by using the lasso regression (model 1). Another easy-to-access model (model 2) was created by using a subset of 16 self-reported covariates. The predictive performance was quantified with c-indices and by studying the means and standard deviations of absolute errors (MAE ± SD) between the pre…
Maldivian Tourist Resorts and their Environmental Impact
1993
In the past two decades, the Maldivians have built up a flourishing tourist industry. Tourist resorts have been established on hitherto uninhabited small islands and by 1990 the number of tourists has increased to nearly 200 000. The Maldivian tourist resorts represent a special type of tropical beach resorts catering only to the tourists’ needs for accommodation, board, leisure and recreation. They are distinctly separate from the islands inhabited by the Maldivians and intercultural communication does not take place. These resorts are in effect ‘tourist enclaves’. Holiday facilities in the resorts are clearly geared to the coastal environment - the beach, lagoon and reef. The impact of to…