Search results for "Topi"
showing 10 items of 3172 documents
Relationship Between the Apolipoprotein E Genotype and LDL Particle Size in Patients With Obstructive Sleep Apnea.
2016
Obstructive sleep apnea (OSA) is associated with dyslipidemia and increased cardiovascular risk. We assessed the effects of apolipoprotein E ( APOE) genotype on low-density lipoprotein (LDL) and high-density lipoprotein (HDL) particle size and lipid subclasses (separated by gradient gel electrophoresis) in patients with OSA. Stable patients (n = 181) prospectively recruited underwent full polysomnography. Both LDL particle size and LDL I proportion were reduced from ∊3∊3 homozygotes to ∊2 carriers and to ∊4 carriers (analysis of variance: P = .024; P = .040, respectively); carriers of the ∊4 allele of the APOE genotype had significantly lower LDL particle size and LDL I proportion compared…
A multicenter study on the appropriateness of hospitalization in obstetric wards: application of Obstetric Appropriateness Evaluation Protocol (Obste…
2015
The cross-sectional study has been based on the implementation of the Obstetric Appropriateness Evaluation Protocol (OAEP) in seven hospitals to determine inappropriate hospital admissions and days of stay. The outcomes were: inappropriateness of admission and "percentage of inappropriateness" for one hospitalization. A total number of 2196 clinical records were reviewed. The mean percentage of inappropriateness for hospitalization was 22%. The percentage of inappropriateness for the first 10 d of hospitalization peaked in correspondence of the fourth (42%). The logistic regression model on inappropriated admission reported that emergency admission was a protective factor (OR = 0.4) and to …
Science Advances
2019
River ecosystems receive and process vast quantities of terrestrial organic carbon, the fate of which depends strongly on microbial activity. Variation in and controls of processing rates, however, are poorly characterized at the global scale. In response, we used a peer-sourced research network and a highly standardized carbon processing assay to conduct a global-scale field experiment in greater than 1000 river and riparian sites. We found that Earth’s biomes have distinct carbon processing signatures. Slow processing is evident across latitudes, whereas rapid rates are restricted to lower latitudes. Both the mean rate and variability decline with latitude, suggesting temperature constrai…
Millennial-scale phase relationships between ice-core and Mediterranean marine records: insights from high-precision 40Ar/39Ar dating of the Green Tu…
2013
International audience; With the advent of annually-resolved polar ice records extending back to 70 ka, marine and continental paleoclimate studies have now matured into a discipline where high-quality age control is essential for putting on an equal pace layer-counted timescale models and Late Quaternary sedimentary records. High-resolution U-Th dating of speleothem records and 40Ar/39Ar dating of globally recorded geomagnetic excursions have recently improved the time calibration of Quaternary archives, reflecting the cross-disciplinary effort made to synchronize the geologic record at the millennial scale. Yet, tie-points with such an absolute age control remain scarce for paleoclimatic …
Newly discovered orichalcum ingots from Mediterranean sea: Further investigation
2021
Abstract In February 2016, 47 ingots were found in the seabed of Contrada Bulala (Gela, CL, Italy) near the site where 40 ingots had previously been recovered. The ingots composition was determined to be a Cu - Zn alloy, dated by the archaeologist to the VI century B.C. This specific alloy was then known as Orichalcum. From an archaeological point of view, the first question raised about the new discovery was whether the ingots of the first and the second excavations belonged to the same shipwreck. Following the previous study, an elemental analysis was performed on the ingots from the second finding by using ICP-OS and ICP-MS techniques. The chemometric treatment of the analytical results …
Advances in Utopian Studies and Sacred Architecture : a culmination of selected research papers from the International Conference on Utopian and Sacr…
2021
This book, on Advances in Utopian Studies and Sacred Architecture, contains selected research from the International Conference on Utopian and Sacred Architecture Studies which was held in association with the university of Campania “Luigi Vanvitelli” of Italy. Research from the conference has undergone a rigorous review process thanks to the book editors and scientific committee of reviewers. The book explores the interdisciplinary field of utopian studies and specifically the relationship between architecture and utopia as one that is long- standing and pervasive. It namely draws upon the transition and even intersections between contemporary and historical geographies of sacred architect…
L’art. 28 dello Statuto e le trasformazioni del lavoro: cinquant’anni portati bene, ma non troppo
2020
L’art. 28 dello Statuto dei lavoratori ha attraversato un cinquantennio di storia del conflitto sindacale italiano. Si tratta di un rimedio ancora attuale, che necessità di un intervento manutentivo alla luce delle trasformazioni del diritto del lavoro. Partendo dalla validità del modello normativo, il saggio individua le criticità per il legislatore in una prospettiva de jure condendo.
Toxicity of the antimalarial artemisinin and its dervatives.
2010
As long as no effective malaria vaccine is available, chemotherapy belongs to the most important weapons fighting malaria. One of the most promising new drug developments is the sesquiterpene artemisinin (ARS) and its derivatives, e.g., artemether, arteether, and sodium artesunate. Large clinical studies and meta-analyses did not show serious side effects, although proper monitoring of adverse effects in developing countries might not be a trivial task. There is a paucity of large-scale clinical trials suitable to detect rare but significant toxicity. Therefore, a final and definitive statement on the safety of artemisinins still cannot be made. In contrast, animal experiments show consider…
Metabolic syndrome in hypertensive patients: An unholy alliance
2014
For many years, it has been recognized that hypertension tends to cluster with various anthropometric and metabolic abnormalities including abdominal obesity, elevated triglycerides, reduced high-density lipoprotein cholesterol, glucose intolerance, insulin resistance and hyperuricemia. This constellation of various conditions has been transformed from a pathophysiological concept to a clinical entity, which has been defined metabolic syndrome (MetS). The consequences of the MetS have been difficult to assess without commonly accepted criteria to diagnose it. For this reason, on 2009 the International Diabetes Federation, the American Heart Association and other scientific organizations pro…
Ultradeep Sequencing Analysis of Population Dynamics of Virus Escape Mutants in RNAi-Mediated Resistant Plants
2012
Plant artificial micro-RNAs (amiRs) have been engineered to target viral genomes and induce their degradation. However, the exceptional evolutionary plasticity of RNA viruses threatens the durability of the resistance conferred by these amiRs. It has recently been shown that viral populations not experiencing strong selective pressure from an antiviral amiR may already contain enough genetic variability in the target sequence to escape plant resistance in an almost deterministic manner. Furthermore, it has also been shown that viral populations exposed to subinhibitory concentrations of the antiviral amiR speed up this process. In this article, we have characterized the molecular evolutiona…