Search results for "Topi"
showing 10 items of 3172 documents
Minimum effective dose for antidepressants - an obligatory requirement for antidepressant drug evaluation?
1996
Extensive clinical trials are required for registration and approval of new antidepressants in most countries including the requirement that a minimal effective dose should be determined. The rationale for this requirement is to avoid the use of unnecessarily high doses. The implication is that for every antidepressant, a dose exists that serves as a threshold, below which all doses are not effective or are clearly less effective in treating a major depressive episode. Dose titration and fixed dose studies are used to determine the minimal effective dose, but both strategies have limitations and often do not allow definite establishment of a clear-cut minimal effective dose. The effort of e…
Targeting apoptosis in solid tumors: the role of bortezomib from preclinical to clinical evidence.
2007
The ubiquitin-proteasome pathway is the main proteolytic system present in the nucleus and cytoplasm of all eukaryotic cells. Apoptosis activation induced by ubiquitin-proteasome pathway inhibition makes the proteasome a new target of anticancer therapy. Bortezomib is the first proteasome inhibitor to be approved by the US FDA; in 2003 as a third line and in 2005 as a second line therapy for the treatment of multiple myeloma only. This review focuses on the use of bortezomib, not only in its therapeutic role but also, more specifically, in its biologic role and discusses the most recent applications of the drug in solid tumors, both at a preclinical and clinical level.
Patients Withdrawing Dupilumab Monotherapy for COVID-19-Related Reasons Showed Similar Disease Course Compared With Patients Continuing Dupilumab The…
2022
N/A
Sealing ability of five different retrograde filling materials.
1996
The sealing ability of Amalgam, Harvard-Cement, Diaket, gold-leaf, and Ketac-Endo as retrofilling materials was investigated. Paper cones were fixed with Harvard-Cement in the instrumented roots of 100 extracted human incisors. Apicectomy was performed and a 2-mm-deep retrograde cavity was prepared. Teeth were assigned to five groups (n = 20); each group received a different filling material. Surfaces of the roots were isolated with nail polish. Teeth, were stored in 1% methylene blue dye for 72 h. Roots were sectioned, and the depth of dye penetration was evaluated through a stereomicroscope. Retrofills with Ketac-Endo showed significantly less leakage compared with amalgam. There was no s…
Climate Fiction and its Narratives
2021
In the late 20th and early 21st centuries, the narratives about a possible environmental collapse and its consequences have multiplied. This is due to a growing awareness about issues such as climate change or the energy crisis. The so-called ‘climate science fiction’ or cli-fi has reflected these concerns in highly successful films, like the two analysed here: The Day After Tomorrow (2004) and The Day the Earth Stood Still (2008), a remake of the 1951 classic. In this paper, I approach both films through an analysis of their plot and narrative structure, focusing mainly on the evolution of their main characters and storylines. I argue that these mainstream productions avoid any examination…
Under Our Eye: Margaret Atwood's Variation on the Panopticon in "The Heart Goes Last"
2020
In her dystopian dark comedy The Heart Goes Last (2015), Margaret Atwood openly refers to Jeremy Bentham’s concept of the Panopticon. The future world depicted in her novel is filled with violence and deprived of both human bonds and hope. Hence, being contained, monitored and — after Foucault — disciplined and punished appears to be the characters’ last resort. Surveillance tempts both sexes as it is politically correct and universal, and it does not privilege one group of people over the other. The article discusses the dystopian vision of the near future as created by Atwood in her 2015 novel, with direct references to the conception of the Panopticon, both in its original meaning propos…
Nueve tesis introductorias sobre la distopía
2021
Nine introductory theses about dystopia
 
 Resumen: Este artículo proporciona una introducción actualizada a la distopía y una exégesis del apogeo ilimitado que esta vive. Y lo hace planteando nueve tesis. El supuesto de partida es que el término “distopía” no designa solamente una forma literaria. Sus premisas, metodologías y actitudes elementales son visibles en el pensamiento social contemporáneo y otras muchas expresiones culturales. En las dos primeras tesis diferencio el género distópico de otros géneros afines y sondeo las coincidencias temáticas que atesoran sus expresiones literarias y filosóficas. A lo largo de las tres tesis posteriores, señalo las causas sociales e ide…
Mediterranean Borders and Diaspora
2020
“And So Europe Dehumanized Itself”, the expression used by Toni Morrison regarding slavery, seems to have returned dramatically to current affairs. We seem to have plunged into a dystopian present in which the European Union, instead of governing the disruptive global migrations through appropriate policies, has expressed such nervousness – both at the popular and institutional levels – to give rise, in an unstoppable crescendo, to practices inspired by xenophobia and racism. It has led to the inhuman treatment of migrants (I refer both to shipwrecks at sea, a real massacre and to the torture and torture reserved for them in Libya with the complicity of European governments) and finally to …
The Double-Deviant Identity of the Mass-Foreigner and the Lack of Authority of the Crimmigrationist State
2019
Crimmigration has its breeding ground in dystopian and securitarian narratives. The anti-hero of these narratives is the mass-foreigner, a stereotyped version of the foreigner usually depicted, alternatively or cumulatively, as an enemy or as a parasite of host societies. But not only does crimmigration presuppose such narratives (and the deviant identity of the mass-foreigner, which is connected with them) as a source of legitimation, it also fuels these same narratives by providing them with an official sanction: by merging criminalization and irregularization on a legal level, it heavily contributes to making the social identity of mass-foreigners into a doubly deviant one. The overarchi…
Postapokalipses un distopijas atainojums Džordža Millera filmā "Mad Max. Fury road"
2016
Bakalaura darbā tiks pētīts austrāļu režisora Džordža Millera filmas “Mad Max. Fury road” postapokaliptiskās un distopiskās vides atainojums un paņēmieni, ar kuriem vide izveidota filmas ietvaros. Teorētiskajā daļā tiks sīkāk apskatītas tēmas un žanri, kā arī semiotiskie un naratīva elementi, kas ietver informāciju, aprakstot autora izvēlētos paņēmienus kā atainot postapokaliptisku un distopisku vidi. Metodoloģijas daļā tiks pamatotas izvēlētās metodes pētījuma izveidei– naratīva un semiotiskā analīze. Pēc metodoloģijas apraksta seko empīriskā daļa, kurā tiks izanalizēta augstākminētā kinofilma. Lai sīkāk pētītu “Mad Max. Fury road”, tiks aprakstīta arī “Mad Max” franšīze kopumā, kurā ietil…