Search results for "Topic"

The effect of treatment with omalizumab, an anti-IgE antibody, on asthma exacerbations and emergency medical visits in patients with severe persisten…

2005

Background:  Patients with severe persistent asthma who are inadequately controlled despite treatment according to current asthma management guidelines have a significant unmet medical need. Such patients are at high risk of serious exacerbations and asthma-related mortality. Methods:  Here, we pooled data from seven studies to determine the effect of omalizumab, an anti-immunoglobulin E (IgE) monoclonal antibody, on asthma exacerbations in patients with severe persistent asthma. Omalizumab was added to current asthma therapy and compared with placebo (in five double-blind studies) or with current asthma therapy alone (in two open-label studies). The studies included 4308 patients (2511 tre…

Setting standards and implementing quality improvement in trauma care

1996

Setting standards and implementing quality improvement in trauma care needs consideration of the definitions of standards, guidelines, recommendations and the present quality of trauma care. Essential factors for consideration are the chain of survival and different intervals which may decide on patient outcome: (a) the trauma (occurrence) to trauma recognition interval which has, until now, not been taken into consideration with regard to morbidity and mortality; (b) the scene time is part of the total prehospital time which comprises rescuing the entrapped patient, preparation of the patient for treatment, and transfer to a rescue vehicle. The medical part of the scene time, however, repr…

Striving to maintain a dignified life for the patient in transition: Next of kin’s experiences during the transition process of an older person in tr…

2015

Next of kin represent significant resources in the care for older patients. The aim of this study was to describe and illuminate the meaning of the next of kin’s experiences during the transition of an older person with continuing care needs from hospital to home. The study has a phenomenological hermeneutic design. Individual, narrative interviews were conducted, and the data analysis was conducted in accordance with Lindseth and Norberg’s phenomenological hermeneutic method. Two themes and four subthemes were identified and formulated. The first theme: “Balancing vulnerability and strength,” encompassed the subthemes “enduring emotional stress” and “striving to maintain security and conti…

Do viscosity and wettability of fluoride varnishes affect their fluoride release?

2020

BACKGROUND: There are several brands of fluoride varnishes in the market, but the dynamics of fluoride release from each one might be different. The purpose of this study was to evaluate in vitro the release of fluorides by fluoride varnishes and to determine the correlation with viscosity and wettability. MATERIAL AND METHODS: Forty four enamel blocks 5x5 mm were randomly divided into 4 groups (n=11) ((Duraphat®, Clinpro™ White Varnish, Flúor Protector® and control). We applied 30 milligrams of fluoride varnish to each specimen. The specimens were immersed in a Calcium Phosphate solution at a pH= 6.0. We evaluated the release of fluoride, by using a selective fluoride electrode, during 6 w…

Endoscopic ultrasonography findings in autoimmune pancreatitis

2011

Endoscopic ultrasonography is an established diagnostic tool for pancreatic masses and chronic pancreatitis. In recent years there has been a growing interest in the worldwide medical community in autoimmune pancreatitis (AIP), a form of chronic pancreatitis caused by an autoimmune process. This paper reviews the current available literature about the endoscopic ultrasonographic findings of AIP and the role of this imaging technique in the management of this protean disease.

H∞ fuzzy control of DC-DC converters with input constraint

2012

Published version of an article in the journal: Mathematical Problems in Engineering. Also available from the publisher at: http://dx.doi.org/10.1155/2012/973082 Open access This paper proposes a method for designing H∞ fuzzy control of DC-DC converters under actuator saturation. Because linear control design methods do not take into account the nonlinearity of the system, a T-S fuzzy model and a controller design approach is used. The designed control not only handles the external disturbance but also the saturation of duty cycle. The input constraint is first transformed into a symmetric saturation which is represented by a polytopic model. Stabilization conditions for the H∞ state feedba…

Co-Citation Analysis of Articles Published in Substance Abuse Journals: Intellectual Structure and Research Fields (2001-2012).

2016

The purpose of this study is to introduce a new methodology in the field of substance abuse, namely, co-citation analysis, which uses the bibliographic references of publications to establish the main thematic areas being researched and to identify the seminal documents that have contributed to establishing the intellectual foundation of the discipline at the present time.We identified all bibliographic references that were cited in documents published in the substance abuse journals included in the Journal Citation Reports in the 2001-2012 period, generating a co-citation matrix. This matrix was used to perform a co-citation network analysis.The co-citation network analysis led to the iden…

Mid-gastrointestinal bleeding: capsule endoscopy and push-and-pull enteroscopy give rise to a new medical term.

2006

Uso de indicadores bibliométricos para el análisis de temas emergentes y su evolución: spin-offs como caso de estudio

2018

[ES] Las spin-offs constituyen una de las áreas de investigación más atractivas, ya que están asociadas con fenómenos como el emprendimiento, la innovación y la transferencia del conocimiento. El presente estudio muestra que la selección y el uso de indicadores bibliométricos permite identificar y caracterizar el desarrollo y la difusión de temas de investigación emergentes como el analizado. Los principales aspectos observados en relación con el desarrollo de la investigación sobre las spin-offs son que se produce un auge en el número de publicaciones después de un largo período de latencia y la marcada naturaleza multidisciplinar del área. El presente enfoque ha analizado la evolución de …

Characterization of a novel population of low-density granulocytes associated with disease severity in HIV-1 infection

2012

The mechanisms resulting in progressive immune dysfunction during the chronic phase of HIV infection are not fully understood. We have previously shown that arginase, an enzyme with potent immunosuppressive properties, is increased in HIV seropositive (HIV+) patients with low CD4(+) T cell counts. Here we show that the cells expressing arginase in peripheral blood mononuclear cells of HIV+ patients are low-density granulocytes (LDGs) and that whereas these cells have a similar morphology to normal-density granulocyte, they are phenotypically different. Importantly, our results reveal that increased frequencies of LDGs correlate with disease severity in HIV+ patients.