Search results for "Topoï"
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Control of the HOXA9 gene expression in the hematopoietic stem/progenitor cells : role of the epigenetic factors MOZ, MLL and of the polyadenylation …
2013
My thesis project has consisted of the study of MOZ, and MLL. They are epigenetic regulators. MOZ and MLL activate transcription of HOX genes, which are transcription factors essential during haematopoiesis. MOZ and MLL have some target genes in common. In our study, we characterised a cooperation between MOZ and MLL in human haematopoietic stem/progenitor cells CD34+. They are both recruited onto HOX promoters. MOZ is essential for MLL recruitment, and this is reciprocal. In conclusion, we provided an example of a mechanism involving a direct cross-talk between two histone modifying enzymes.In order to dissect the mechanism of action of this complex, we decided to identify novel proteins i…
TOPICS
2018
Our problematic concerns the links between logic and topoï, semantics and topoï and finally between logic and semantics. The work therefore consists in highlighting the durability of the notion of topos, its evolution and its integration in logic, in semantics and even in computer science. From then on, topoi, logic and semantics are the three facets of this problematic. The purpose of this thesis is to present the history of topoi, to identify their linguistic properties. It also shows that this notion is present in all linguistic approaches and that semantics is the unifying axis of all linguistic research.It is not our intention to give a new definition, but we have tried to su…