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Mechanochemical Syntheses of N-Containing Heterocycles with TosMIC

2021

A mechanochemical van Leusen pyrrole synthesis with a base leads to 3,4-disubstitued pyrroles in moderate to excellent yields. The developed protocol is compatible with a range of electron-withdrawing groups and can also be applied to the synthesis of oxazoles. Attempts to mechanochemically convert the resulting pyrroles into porphyrins proved to be difficult.

chemistry.chemical_compoundchemistryOrganic ChemistryTosMICCombinatorial chemistryPyrroleThe Journal of Organic Chemistry
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