Search results for "Toxins."

showing 10 items of 797 documents

Fissurectomy combined with anoplasty and injection of botulinum toxin in treatment of anterior chronic anal fissure with hypertonia of internal anal …

2010

Abstract BACKGROUND: In patients affected by anterior chronic anal fissure (CAAF) with hypertonia of the internal anal sphincter (IAS), the role of IAS hypertonia remains unclear. The aim of this study was to evaluate the efficacy of fissurectomy combined with advancement flap and IAS injection of botulinum toxin in healing the CAAF with hypertonia of IAS resistant to medical therapy. METHODS: Ten consecutive patients were enrolled. Anorectal manometry was performed preoperatively and at 6 months. CAAF with hypertonia was defined as those associated with maximum resting pressure (MRP) values higher than 85 mmHg. All patients underwent fissurectomy and anoplasty with advancement skin flap co…

AdultMalemedicine.medical_specialtyAdolescentPilot ProjectsInjections IntramuscularSurgical FlapsInternal anal sphincterCohort StudiesYoung AdultMuscle HypertoniamedicineHumanschronic anal fissureBotulinum Toxins Type ADefecationbusiness.industryAnorectal manometryGastroenterologyRecovery of FunctionMiddle AgedBotulinum toxinColorectal surgerySurgeryClinical trialTreatment OutcomeNeuromuscular AgentsAnesthesiaAnterior chronic anal fissure Fissurectomy Advancement flap Botulinum toxin.HypertoniaDefecationSurgeryFemaleFissure in Anomedicine.symptombusinessmedicine.drugAbdominal surgeryTechniques in coloproctology
researchProduct

Advancement flap in the management of chronic anal fissure: A prospective study

2012

Lateral internal sphincterotomy is the surgical treatment of choice of chronic anal fissure after failure of conservative measures. Several randomized trials identified an overall risk of incontinence of 10 % mostly for flatus. Fissurectomy is the most commonly used procedure to preserve the integrity of the anal sphincters. However, a possible complication is keyhole defect that may lead to faecal soiling. In this study, chronic anal fissure (CAF) was treated by fissurectomy and anal advancement flap to preserve the anatomo-functional integrity of sphincters and to reduce healing time and the risk of anal stenosis. In patients with hypertonia, surgical treatment was combined with chemical …

AdultMalemedicine.medical_specialtyAdolescentmedicine.medical_treatmentInjections IntramuscularSurgical FlapsFissurectomyFollow-Up StudieInternal anal sphincterAnal stenosismedicineDeformityHumansReconstructive Surgical ProcedureProspective StudiesKeyhole defectBotulinum Toxins Type ADigestive System Surgical ProceduresAdvancement flapAgedNeuromuscular Agentbusiness.industryUrinary retentionDigestive System Surgical ProcedureRecovery of FunctionPlastic Surgery ProceduresMiddle AgedSurgerySurgical FlapProspective StudieSettore MED/18 - Chirurgia GeneraleTreatment OutcomeNeuromuscular AgentsAnesthesiaChronic DiseaseDefecationHypertoniaFemaleSurgeryFissure in AnoAdvancement flap; Chronic anal fissure; Fissurectomy; Adolescent; Adult; Aged; Botulinum Toxins Type A; Chronic Disease; Digestive System Surgical Procedures; Female; Fissure in Ano; Follow-Up Studies; Humans; Injections Intramuscular; Male; Middle Aged; Neuromuscular Agents; Prospective Studies; Reconstructive Surgical Procedures; Recovery of Function; Treatment Outcome; Surgical Flaps; Surgerymedicine.symptombusinessLateral internal sphincterotomyChronic anal fissureFollow-Up StudiesHuman
researchProduct

Long-term follow-up (42 months) of chronic anal fissure after healing with botulinum toxin.

2002

Abstract Background & Aims: Botulinum toxin is an effective treatment in idiopathic chronic anal fissure, but the long-term outcome after healing is not well documented. We analyzed the long-term outcome of patients in whom an anal fissure had healed after botulinum toxin injection and the factors contributing to recurrence. Methods: Fifty-seven patients who had completely healed 6 months after injection of botulinum toxin were reassessed every 6 months. The follow-up was 42 months in all patients. Clinical and manometric differences between the permanently healed and the relapsed group were statistically analyzed. Results: Four patients were lost to follow-up. A fissure recurrence was show…

AdultMalemedicine.medical_specialtyBotulinum ToxinsLong term follow upmedicine.medical_treatmentChronic anal fissureInjectionsRecurrenceLate RecurrencemedicinePressureEffective treatmentHumansAgedAnal fissureChemotherapyWound HealingHepatologyDose-Response Relationship Drugbusiness.industryGastroenterologyMiddle Agedmedicine.diseaseBotulinum toxinSurgeryTotal doseChronic DiseaseRetreatmentFemaleFissure in Anobusinessmedicine.drugFollow-Up StudiesGastroenterology
researchProduct

Improvement of wound healing after hemorrhoidectomy: a double-blind, randomized study of botulinum toxin injection.

2005

PURPOSE: Hemorrhoidectomy is usually associated with significant pain during the postoperative period. The spasm of the internal sphincter seems to play in important role in the origin of pain. This study was designed to evaluate the effectiveness of intrasphincter injection of botulinum toxin after hemaorrhoidectomy in reducing the maximum testing pressure of the anal canal, accelerating wound healing, and decreasing postoperative pain when resting and during defecation. METHODS: Thirty patients with hemorrhoids of third and fourth degree were included in the study and randomized in two groups. Anorectal manometry was performed preoperatively and 5 and 30 days afterward ill all patients un…

AdultMalemedicine.medical_specialtyBotulinum ToxinsManometrymedicine.medical_treatmentAnal CanalPainSodium ChlorideHemorrhoidsInternal anal sphincterHemorrhoidsDouble-Blind MethodPressureMedicineHumansbotulinum toxinDefecationSalineWound Healingposthemorrhoidectomy painbusiness.industryAnti-Dyskinesia AgentshemorrhoidectomyUrethral sphincterAnorectal manometryGastroenterologyGeneral MedicineAnal canalMiddle Agedmedicine.diseaseBotulinum toxinSurgerymedicine.anatomical_structureTreatment OutcomeAnesthesiaDefecationFemalebusinessmedicine.drugDiseases of the colon and rectum
researchProduct

Preoperative Botulinum Toxin and Progressive Pneumoperitoneum Are Useful in the Treatment of Large Incisional Hernias.

2019

AdultMalemedicine.medical_specialtyBotulinum ToxinsNeurotoxinsMEDLINEPneumoperitoneumPreoperative CaremedicineHumansHerniaAgedRetrospective StudiesAged 80 and overbusiness.industryRetrospective cohort studyGeneral MedicineMiddle Agedmedicine.diseaseBotulinum toxinHernia VentralSurgeryFemalebusinessPneumoperitoneum Artificialmedicine.drugThe American surgeon
researchProduct

Botulinum toxin A (Botox) and sweating-dose efficacy and comparison to other BoNT preparations.

2004

Abstract Background Botulinum toxin type A (BoNT/A) is 20–50 times more effective than Botulinum toxin type B (BoNT/B) concerning the treatment of muscular hypercontractions [Sloop, R.R., Cole, B.A., Escutin, R.O., 1997. Human response to botulinum toxin injection: type B compared with type A. Neurology 49, 189–194]. Botulinum toxins block motor nerves as well as autonomic fibres [Rand, M.J., Whaler, B.C., 1965. Impairment of sympathetic transmission by botulinum toxin. Nature 206, 588–591]. Objective Purpose of this study was to analyse the dose dependent reduction of sweating using the BoNT/A preparation Botox® and to compare the results with our earlier results analysing Dysport® [Braune…

AdultMalemedicine.medical_specialtyBotulinum ToxinsTime FactorsInjections SubcutaneousSweatingBotulinum toxin aCellular and Molecular NeuroscienceMedicineHumansBotulinum toxin type BAnhidrosisBotulinum Toxins Type AHypohidrosisDose-Response Relationship DrugEndocrine and Autonomic Systemsbusiness.industryStarchBotulinum toxinSurgerySudomotorDose–response relationshipThreshold doseNeuromuscular AgentsAnesthesiaFemaleNeurology (clinical)medicine.symptombusinessBotulinum toxin typemedicine.drugFollow-Up StudiesAutonomic neuroscience : basicclinical
researchProduct

Pathophysiologic quantities of endotoxin-induced tumor necrosis factor-alpha release in whole blood from patients with chronic heart failure.

2002

Bacterial endotoxin activity is elevated in patients with decompensated chronic heart failure (HF) and acts as a potent stimulus for immune activation. We sought to determine whether endotoxin, at an activity level seen in vivo (around 0.6 EU/ml), is sufficient to stimulate the secretion of tumor necrosis factor-alpha (TNF-alpha) and TNF-alpha soluble receptor (sTNFR2) in ex vivo whole blood from patients with HF. We studied 15 patients with HF (aged 65 +/- 1.9 years, New York Heart Association class 2.1 +/- 0.3, left ventricular ejection fraction 31 +/- 5%; mean +/- SEM), of whom 5 had cardiac cachexia, and 7 healthy control subjects (59 +/- 5 years, p = NS). Reference endotoxin was added …

AdultMalemedicine.medical_specialtyCachexiaEnzyme-Linked Immunosorbent AssayReceptors Tumor Necrosis FactorCachexiaIn vivoInternal medicinemedicineHumansWhole bloodAgedHeart FailureEjection fractionbusiness.industryTumor Necrosis Factor-alphaVenous bloodMiddle Agedmedicine.diseaseEndotoxinsEndocrinologyHeart failureTumor necrosis factor alphaFemaleCardiology and Cardiovascular MedicinebusinessEx vivoThe American journal of cardiology
researchProduct

Biomonitoring of Multiple Mycotoxins in Urine by GC–MS/MS: A Pilot Study on Patients with Esophageal Cancer in Golestan Province, Northeastern Iran

2021

A pilot study to investigate the occurrence of 10 mycotoxins (deoxynivalenol, DON

AdultMalemedicine.medical_specialtyEsophageal NeoplasmsLiquid Phase MicroextractionHealth Toxicology and Mutagenesislcsh:MedicinePilot ProjectsUrineIranToxicologymedicine.disease_cause01 natural sciencesGastroenterologyDiacetoxyscirpenolGas Chromatography-Mass SpectrometryArticlechemistry.chemical_compoundYoung Adult0404 agricultural biotechnologyInternal medicinemycotoxinsmedicineHumansZearalanoneesophageal cancerMycotoxinZearalenoneAgedAged 80 and overCreatininebusiness.industryToxin010401 analytical chemistrylcsh:RGC–MS/MSurine biomarkers04 agricultural and veterinary sciencesMiddle Aged040401 food science0104 chemical scienceschemistryCase-Control StudiesBody BurdenFemaleGas chromatography–mass spectrometrybusinessBiological MonitoringToxins
researchProduct

Botulinum toxin to avoid component separation in midline large hernias.

2020

Abstract Background The goal of our study was to compare results in patients with large midline incisional hernia using modified anterior component separation versus preoperative botulinum toxin and following Rives repair, with a focus on surgical site occurrences, possibility of fascial closure, duration of hospital stay, and hernia recurrence rate. Methods From to March 2016 to June 2019, a prospective comparative study was performed in 80 consecutive patients with large midline incisional hernias and hernia transverse diameters between 11 and 17 cm under elective hernia repair at our tertiary center. Two groups were analyzed prospectively: 40 patients with preoperative botulinum toxin ad…

AdultMalemedicine.medical_specialtyIncisional herniamedicine.medical_treatment030230 surgeryInjections Intramuscular03 medical and health sciences0302 clinical medicineSurgical sitePreoperative CaremedicineHumansIncisional HerniaHerniaIn patientProspective StudiesBotulinum Toxins Type AHerniorrhaphyAbdominal MusclesAgedSurgical repairbusiness.industryAbdominal WallMiddle AgedHernia repairmedicine.diseaseBotulinum toxinComponent separationHernia VentralSurgeryElective Surgical Procedures030220 oncology & carcinogenesisSurgeryFemalebusinessTomography X-Ray Computedmedicine.drugSurgery
researchProduct

Botulinum toxin vs. topical glyceryl trinitrate ointment for pain control in patients undergoing hemorrhoidectomy: a randomized trial.

2007

PURPOSE: The maximum resting pressure in the anal canal is greatly raised after hemorrhoidectomy. This increase is likely to be the cause of postoperative pain, which is still the most troublesome early problem after hemorrhoidectomy. This study was designed to compare, after hemorrhoidectomy, the effects of intrasphincter injection of botulinum toxin vs. application of glyceryl trinitrate ointment in improving wound heating and reducing postoperative pain at rest or during defecation. METHODS: Thirty patients with hemorrhoids of third and fourth degree were included in the study and randomized in two groups. Anorectal manometry was performed preoperatively and 5 and 40 days after hemorrhoi…

AdultMalemedicine.medical_specialtyManometryRestMULTICENTERPLACEBO-CONTROLLED TRIALHemorrhoidslaw.inventionInjectionsOintmentsNITROGLYCERIN OINTMENTNitroglyceringlyceryl trinitrateHemorrhoidsHEADACHERandomized controlled triallawmedicineHumansbotulinum toxinBotulinum Toxins Type AAdverse effectDefecationNEURONSPain MeasurementPain PostoperativeNITRIC-OXIDEhemorrhoidectomy CHRONIC ANAL-FISSUREbusiness.industryAnorectal manometryGastroenterologyGeneral MedicineAnal canalmedicine.diseaseDOUBLE-BLIND TRIALBotulinum toxinColorectal surgerySurgerymedicine.anatomical_structureTreatment OutcomeSPHINCTEROTOMYNeuromuscular AgentsAnesthesiaDefecationFemalebusinessmedicine.drugDiseases of the colon and rectum
researchProduct