Search results for "Trail"

Angiogenic and/or pro-apoptotic factors are shed from brain cells via extracellular vesicles

2008

We set a three-cell type coculture system in which neurons and astrocytes synergistically induce brain capillary endothelial cells to form a monolayer with permeability properties resembling those of the physiological blood-brain barrier (BBB) (Schiera et al., 2003; Schiera et al., 2005). On the basis of immunofluorescence, scanner electron microscopy and western blot analyses, we also suggested that both astrocytes and neurons in culture shed extracellular vesicles that contain FGF-2 and VEGF, as well as beta1-integrin, a membrane protein that can be considered a marker of shedding (Schiera et al, 2007; Proia et al., 2008). In addition, it was already known that transformed glial cells (ol…

TRAIL acts synergistically with iron oxide nanocluster-mediated magneto- and photothermia

2019

International audience; Targeting TRAIL (Tumor necrosis factor (TNF)-Related Apoptosis-Inducing Ligand) receptors for cancer therapy remains challenging due to tumor cell resistance and poor preparations of TRAIL or its derivatives. Herein, to optimize its therapeutic use, TRAIL was grafted onto iron oxide nanoclusters (NCs) with the aim of increasing its pro-apoptotic potential through nanoparticle-mediated magnetic hyperthermia (MHT) or photothermia (PT). Methods: The nanovector, NC@TRAIL, was characterized in terms of size, grafting efficiency, and potential for MHT and PT. The therapeutic function was assessed on a TRAIL-resistant breast cancer cell line, MDA-MB-231, wild type (WT) or T…

TB-Structure : Collective Intelligence for Exploratory Keyword Search

2017

In this paper we address an exploratory search challenge by presenting a new (structure-driven) collaborative filtering technique. The aim is to increase search effectiveness by predicting implicit seeker’s intents at an early stage of the search process. This is achieved by uncovering behavioral patterns within large datasets of preserved collective search experience. We apply a specific tree-based data structure called a TB (There-and-Back) structure for compact storage of search history in the form of merged query trails – sequences of queries approaching iteratively a seeker’s goal. The organization of TB-structures allows inferring new implicit trails for the prediction of a seeker’s i…

Methodical redesign of a semitrailer

2005

Synergistic effects induced by combinations of the synthetic cannabinoid WIN55,212-2 and the death receptor ligand TRAIL in hepatoma HepG2 cells.

2008

Hałdy poprzemysłowe - ich kulturowy i turystyczny potencjał (na przykładzie wybranych obiektów w województwie śląskim)

2018

Hałdy należą do antropogenicznych form ukształtowanych przez człowieka, kojarzone są przede wszystkim z degradacją środowiska przyrodniczego. Materiał na nich składowany (skały, żużel, popiół) związany jest głównie z przemysłem wydobywczym, hutniczym i energetycznym. Na terenie województwa śląskiego takich obiektów jest najwięcej w kraju, co ma bezpośredni związek z intensywną industrializacją i urbanizacją tego obszaru od połowy XIX wieku. Współcześnie, choć wiele z nich zmieniło swój wygląd (zostały poddane procesom rekultywacji), nadal – obok szybów kopalnianych – są rozpoznawalnym symbolem tego regionu. W artykule autorka zawraca uwagę na kulturowe znaczenie hałd poprzemysłowych na prze…