Search results for "Transferability"
showing 3 items of 23 documents
Species distributions models may predict accurately future distributions but poorly how distributions change: A critical perspective on model validat…
2023
Aim: Species distribution models (SDMs) are widely used to make predictions on how species distributions may change as a response to climatic change. To assess the reliability of those predictions, they need to be critically validated with respect to what they are used for. While ecologists are typically interested in how and where distributions will change, we argue that SDMs have seldom been evaluated in terms of their capacity to predict such change. Instead, typical retrospective validation methods estimate model's ability to predict to only one static time in future. Here, we apply two validation methods, one that predicts and evaluates a static pattern, while the other measures change…
External evaluation of population pharmacokinetic models of vancomycin in neonates: the transferability of published models to different clinical set…
2013
Vancomycin is one of the most evaluated antibiotics in neonates using modeling and simulation approaches. However no clear consensus on optimal dosing has been achieved. The objective of the present study was to perform an external evaluation of published models, in order to test their predictive performances in an independent dataset and to identify the possible study-related factors influencing the transferability of pharmacokinetic models to different clinical settings. Published neonatal vancomycin pharmacokinetic models were screened from the literature. The predictive performance of 6 models was evaluated using an independent dataset (112 concentrations from 78 neonates). The evaluati…
An Italian experience on crash modeling for roundabouts
2015
In the last few years a considerable amount of safety models and evaluation tasks have been developed and specifically dedicated to roundabouts. Several safety performance functions (SPFs), indeed, have been implemented for roundabouts worldwide. Since SPFs are developed using crashes, traffic volume and other characteristics of a specific site (or geographical area), their direct transferability to other contexts different from those in which SPFs were calibrated is not always possible and, in any case, it must be done very carefully. A safety performance function cannot be used without a transferability evaluation for sites not included in the geographic area for which it was developed. S…