Search results for "Transform"

The repair of oxidized purines in the DNA of human lymphocytes requires an activation involving NF-YA-mediated upregulation of OGG1.

2014

8-Oxoguanine DNA glycosylase (OGG1), which initiates the repair of DNA purine modifications such as 8-oxo-7,8-dihydroguanine (8-oxoG), is often regarded as a house keeping protein ubiquitously active in mammalian cells. We have analysed the repair rates of oxidized purines generated by photosensitization in peripheral human lymphocytes and observed that the cells were virtually unable to remove these lesions (less than 10% removal within 24h). However, stimulation of the lymphocytes with phytohemagglutinin (PHA) strongly accelerated the repair so that ∼30% of the lesions were repaired within 4h. Within 24h following PHA stimulation and preceding the induction of cell proliferation, Western …

Regulation of the tumor marker Fascin by the viral oncoprotein Tax of human T-cell leukemia virus type 1 (HTLV-1) depends on promoter activation and …

2015

AbstractAdult T-cell leukemia/lymphoma is a highly infiltrative neoplasia of CD4+ T-lymphocytes that occurs in about 5% of carriers infected with the deltaretrovirus human T-cell leukemia virus type 1 (HTLV-1). The viral oncoprotein Tax perturbs cellular signaling pathways leading to upregulation of host cell factors, amongst them the actin-bundling protein Fascin, an invasion marker of several types of cancer. However, transcriptional regulation of Fascin by Tax is poorly understood. In this study, we identified a triple mode of transcriptional induction of Fascin by Tax, which requires (1) NF-κB-dependent promoter activation, (2) a Tax-responsive region in the Fascin promoter, and (3) a p…

TGFβ-induced EMT requires focal adhesion kinase (FAK) signaling

2007

The epithelial-to-mesenchymal transition (EMT) is a crucial process, occurring both during development and tumor progression, by which an epithelial cell undergoes a conversion to a mesenchymal phenotype, dissociates from initial contacts and migrates to secondary sites. We recently reported that in hepatocytes the multifunctional cytokine TGFβ induces a full EMT characterized by (i) Snail induction, (ii) E-cadherin delocalization and down-regulation, (iii) down-regulation of the hepatocyte transcriptional factor HNF4α and (iv) up-regulation of mesenchymal and invasiveness markers. In particular, we showed that Snail directly causes the transcriptional down-regulation of E-cadherin and HN…

The Wilms' tumor suppressor gene (wt1) product regulates Dax-1 gene expression during gonadal differentiation.

1999

Gonadal differentiation is dependent upon a molecular cascade responsible for ovarian or testicular development from the bipotential gonadal ridge. Genetic analysis has implicated a number of gene products essential for this process, which include Sry, WT1, SF-1, and DAX-1. We have sought to better define the role of WT1 in this process by identifying downstream targets of WT1 during normal gonadal development. We have noticed that in the developing murine gonadal ridge, wt1 expression precedes expression of Dax-1, a nuclear receptor gene. We document here that the spatial distribution profiles of both proteins in the developing gonad overlap. We also demonstrate that WT1 can activate the D…

Texture analysis with statistical methods for wheat ear extraction

2007

In agronomic domain, the simplification of crop counting, necessary for yield prediction and agronomic studies, is an important project for technical institutes such as Arvalis. Although the main objective of our global project is to conceive a mobile robot for natural image acquisition directly in a field, Arvalis has proposed us first to detect by image processing the number of wheat ears in images before to count them, which will allow to obtain the first component of the yield. In this paper we compare different texture image segmentation techniques based on feature extraction by first and higher order statistical methods which have been applied on our images. The extracted features are…

Jürgen Habermas and the risk of liberal eugnics for the ethical self-understanding of species

2016

The article analyzes the problem of human nature that presents Jürgen Habermas in his work The future of human nature, Towards a liberal eugenics? The rapid advances in biotechnology demand a rigorous bioethical reflection that the German philosopher confronts superimposing to his ethics of the discourse a new ethics of the species. Habermas outlines a model of human nature built on precepts such as human dignity and dignity of the human life, symmetry of people's inter-relationships and, as a result of these, the ethical self-understanding of the species. Regarding the liberal eugenics, the author criticizes positive eugenics and protects the negative one, for which bases its argument abou…

Tema 2. L'educació. Introducció conceptual.

2016

El document forma part dels materials docents programats mitjançant l'ajut del Servei de Política Lingüística de la Universitat de València Resum de les diferents perspectives pedagògiques i dels tipus de docents.

La transformació del món agrari: la ciència i la indústria valenciana (1845-1936)

1996

La estructura de la propiedad de la tierra y los cultivos en la Ribera Baixa durante el siglo XIX: el caso de Cullera

1978

An Outline of Morpho-Constructional Analysis

1991

A concept of morpho-constructional analysis is outlined which describes functions of organic features in terms of transformation of energy input into effect output on the strength of physical principles. The dependence of effect outputs on constructional parameters, such as geometrical configurations and material properties, is illustrated in a vector model. It shows that performances of organisms, on principle, can be provided in equivalent manner by different constructional solutions. Options exist in regards to (1) how constructional parameters can be provided by an organism, (2) how particular effects or performances can be produced, and (3) how organizational units can be constrained b…