Search results for "Transform"
showing 10 items of 3975 documents
A New Concept of R&D in NEO Open Innovation : Transformation of R&D Triggered By Amazon
2019
Amazon was the world’s top R&D firm in 2017. Its R&D investment was double that of 2015, quintuple that of 2012, and tenfold that of 2011. It deploys a unique R&D model as conducting “routine or periodic alternations” and “significant improvement” simultaneously. Since traditionally the former is classified as non-R&D, Amazon’s rapid and notable increase has raised the question of a new R&D definition in the digital economy. By means of an empirical analysis of the Amazon’s R&D model, this paper attempted to provide a convincing answer to this question. Amazon has invested considerable resources in extremely innovative business areas, which has developed its assimilation capacity. In parall…
Farming on the margins : Just transition and the resilience of peripheral farms
2022
Sustainability transition demands fundamental changes taking place at the farm system level. At the same time, many farms are operating on the verge of financial profitability, especially in geographically disadvantaged peripheral regions with a limited range of production opportunities. These observations raise concerns about the transition's justice aspects. Using the concept of resilience, we analysed farmers’ capacities for transformation in a peripheral context in Finland. The results from our farmer survey (n = 577) indicated that the regime exerts a strong cost-price squeeze on farmers, escaping of which is difficult also for farmers deliberately seeking new pathways beyond it. Due t…
Transitions through the dynamics of adaptive cycles : Evolution of the Finnish agrifood system
2023
CONTEXT The escalating sustainability problems of the current agrifood regime call for a radical, systemic transformation. Such a transformation implies a move into a new stability domain, defined by a new set of systemic attractors. These transformations can be conceptualised as regime shifts. OBJECTIVE In this study, we explored the history of the Finnish agrifood system in order to learn from the past transformations of the system and to inform the current attempts to steer its development in a more sustainable direction. METHODS We conducted a qualitative analysis on literature discussing the history of the Finnish agrifood system by utilising the concept of the adaptive cycle, which ca…
Grass Pea
2011
Grass pea (Lathyrus. sativus L.) is an annual legume crop with high protein content and remarkable resistance to extreme environmental conditions, including fl ooding, drought, salinity and low soil fertility, and a signifi cant degree of resistance to biotic stress agents. It is rightly considered one of the most promising sources of calories and protein for the vast and expanding populations of drought-prone and marginal areas of Asia and Africa and as an interesting alternative for cropping systems diversifi cation in marginal lands in Europe, Australia and America. It is a dual purpose crop with great agronomic potential as a grain and forage legume. Nevertheless, as a result of the lit…
Rho GTPases are over-expressed in human tumors.
1999
Small GTPases of the Rho family are involved in the regulation of a variety of cellular processes, such as the organization of the microfilamental network, cell-cell contact and malignant transformation. To address the question of whether Rho proteins are involved in carcinogenesis in man, we compared their expression in tumors from colon, breast and lung with that of the corresponding normal tissue originating from the same patient. As shown by Rho-specific 32P-ADP-ribosylation, as well as Western-blot analysis, the amount of RhoA protein was largely increased in all 3 types of tumors tested. The most dramatic differences in the expression of Rho GTPases were observed in breast tissue. All…
Rho GTPases: Promising Cellular Targets for Novel Anticancer Drugs
2006
Ras-homologous (Rho) GTPases play a pivotal role in the regulation of numerous cellular functions associated with malignant transformation and metastasis. Rho GTPases are localized at membranes and become activated upon stimulation of cell surface receptors. In their GTP-bound (=active) state, Rho proteins bind to effector proteins, thereby triggering specific cellular responses. Members of the Rho family of small GTPases are key regulators of actin reorganization, cell motility, cell-cell and cell-extracellular matrix (ECM) adhesion as well as of cell cycle progression, gene expression and apoptosis. Each of these functions is of importance for the development and progression of cancer. Fu…
Chirurgische Ausbildung im digitalen Zeitalter – Virtual Reality, Augmented Reality und Robotik im Medizinstudium
2021
The digital transformation of healthcare is changing the medical profession. Augmented/Virtual Reality (AR/VR) and robotics are being increasingly used in different clinical contexts and require supporting education and training, which must begin within the medical school. There is currently a large discrepancy between the high demand and the number of scientifically proven concepts. The aim of this thesis was the conceptual design and structured evaluation of a newly developed learning/teaching concept for the digital transformation of medicine, with a special focus on the influence of surgical teaching.Thirty-five students participated in three courses of the blended learning curriculum "…
MbCo in Saccharide Solid Amorphous Systems: A Combined FTIR and SAXS Study
2011
Saccharides, and in particular trehalose, are known for their efficiency in protecting biostructures against environmental stress [1], although the preservation mechanism is still debated. Experiments and simulations [2,3] on carboxy-myoglobin (MbCO) showed that the protein dynamics is highly inhibited in dry trehalose matrices, the inhibition being dependent on the water content. In these conditions, a mutual protein-matrix structural and dynamic influence is observed.Here we report a combined FTIR and SAXS study on MbCO embedded in dry amorphous matrices of trehalose and sucrose. FTIR measurements were performed at different protein/sugar ratios, focussing on the stretching band of the bo…
Visual saliency by keypoints distribution analysis
2011
In this paper we introduce a new method for Visual Saliency detection. The goal of our method is to emphasize regions that show rare visual aspects in comparison with those showing frequent ones. We propose a bottom up approach that performs a new technique based on low level image features (texture) analysis. More precisely, we use SIFT Density Maps (SDM), to study the distribution of keypoints into the image with different scales of observation, and its relationship with real fixation points. The hypothesis is that the image regions that show a larger distance from the mode (most frequent value) of the keypoints distribution over all the image are the same that better capture our visual a…
An Examination of the Relationship Between Coaches’ Transformational Leadership and Athletes’ Personal and Group Characteristics in Elite Youth Soccer
2021
There is a growing body of the literature highlighting the positive impact of transformational leadership behaviours across contexts, including sport. However, there is a lack of knowledge of this relationship within elite sport settings. Thus, the purpose of the present study was to examine the relationship between elite youth athletes’ perceptions of coaches’ transformational coaching-behaviours and variables that have been linked to transformational leadership in other settings (i.e., group cohesion, motivational climate, self-regulation of learning and athlete satisfaction). Norwegian elite youth soccer players (n= 753) selected into the national talent development program completed que…