Search results for "Transient"

Cross-entropy-based adaptive optimization of simulation parameters for Markovian-driven service systems

2005

Abstract Markov fluid models represent a general description of the process of service request arrivals to service systems. The solution of performance analysis problems incorporating them often calls for a simulation approach, for which a reference methodology is Importance Sampling. However, in this case the appropriate choice of the biasing conditions is a problem in itself. In this paper an iterative method based on the cross-entropy is proposed for this choice. The equations are given that allow to derive the biasing conditions from the simulation itself. The application of the proposed method to three different sample cases, referring to one transient scenario (finite time horizon and…

On the use of a meshless solver for PDEs governing electromagnetic transients

2009

In this paper some key elements of the Smoothed Particle Hydrodynamics methodology suitably reformulated for analyzing electromagnetic transients are investigated. The attention is focused on the interpolating smoothing kernel function which strongly influences the computational results. Some issues are provided by adopting the polynomial reproducing conditions. Validation tests involving Gaussian and cubic B-spline smoothing kernel functions in one and two dimensions are reported.

Northern Hemisphere atmospheric pattern enhancing Eastern Mediterranean Transient-type events during the past 1000 years

2021

High-resolution climate model simulations for the last millennium were used to elucidate the main winter Northern Hemisphere atmospheric pattern during enhanced Eastern Mediterranean Transient (EMT-type) events, a situation in which an additional overturning cell is detected in the Mediterranean at the Aegean Sea. The differential upward heat flux between the Aegean Basin and the Gulf of Lion was taken as a proxy of EMT-type events and correlated with winter mean geopotential height at 500 mbar in the Northern Hemisphere (20–90∘ N and 100∘ W–80∘ E). Correlations revealed a pattern similar to the East Atlantic/Western Russian (EA/WR) mode as the main driver of EMT-type events, with the past …

Mediterranean circulation perturbations over the last five centuries: Relevance to past Eastern Mediterranean Transient-type events

2016

The Eastern Mediterranean Transient (EMT) occurred in the Aegean Sea from 1988 to 1995 and is the most significant intermediate-to-deep Mediterranean overturning perturbation reported by instrumental records. The EMT was likely caused by accumulation of high salinity waters in the Levantine and enhanced heat loss in the Aegean Sea, coupled with surface water freshening in the Sicily Channel. It is still unknown whether similar transients occurred in the past and, if so, what their forcing processes were. In this study, sediments from the Sicily Channel document surface water freshening (SCFR) at 1910 ± 12, 1812 ± 18, 1725 ± 25 and 1580 ± 30 CE. A regional ocean hindcast links SCFR to enhanc…

The Dual/Global Value of SARS-CoV-2 Genome Surveillance on Migrants Arriving to Europe via the Mediterranean Routes.

2021

Despite the pandemic, 34,154 migrants, refugees or asylum-seekers landed in Sicily (Italy) in 2020, representing the main point of entry by sea into Europe. The SARS-CoV-2 surveillance program among migrants arriving to Sicily via the Mediterranean Sea, made by the combination of clinical examination and molecular testing, has been integrated by full-genome sequencing strains using the NGS technology from the last week of February. To date, more than one hundred full-genome strains have been sequenced and 8 different lineages have been identified mostly belonging to the lineages B.1.1.7 and B.1.525. As global access to COVID-19 vaccines should be ensured, the need to provide more detailed i…

Constructing transient response probability density of non-linear system through complex fractional moments

2014

Abstract The probability density function for transient response of non-linear stochastic system is investigated through the stochastic averaging and Mellin transform. The stochastic averaging based on the generalized harmonic functions is adopted to reduce the system dimension and derive the one-dimensional Ito stochastic differential equation with respect to amplitude response. To solve the Fokker–Plank–Kolmogorov equation governing the amplitude response probability density, the Mellin transform is first implemented to obtain the differential relation of complex fractional moments. Combining the expansion form of transient probability density with respect to complex fractional moments an…

TRPA1 channel is a cardiac target of mIGF-1/SIRT1 signaling.

2014

Cardiac overexpression of locally acting muscle-restricted (m)IGF-1 and the consequent downstream activation of NAD+-dependent protein deacetylase sirtuin 1 (SIRT1) trigger potent cardiac antioxidative and antihypertrophic effects. Transient receptor potential (TRP) cation channel A1 (TRPA1) belongs to the TRP ion channel family of molecular detectors of thermal and chemical stimuli that activate sensory neurons to produce pain. Recently, it has been shown that TRPA1 activity influences blood pressure, but the significance of TRPA1 in the cardiovascular system remains elusive. In the present work, using genomic screening in mouse hearts, we found that TRPA1 is a target of mIGF-1/SIRT1 sign…

A full wave three dimensional meshless approach for electromagnetic transients

2010

Suppression of ischemia-induced fos expression and AP-1 activity by an antisense oligodeoxynucleotide to c-fos mRNA.

1994

The molecular events of brain adaptation to injury that may underlie functional recovery after stroke remain largely undefined. Recent observations of altered gene expression in ischemic brain using animal stroke models have opened new avenues for exploration of the biochemical cascades after stroke [1–11]. These postischemic events include an increase in extracellular excitatory amino acid neurotransmitters such as glutamate. Glutamate receptor–mediated activation of phospholipases and protein kinases results in the alteration of nuclear regulatory processes, including the expression of immediate early genes such as c-fos, junB, and c-jun [5, 12]. The Fos, Jun, and JunB proteins have been …

Random telegraph signal transients in active logarithmic continuous-time vision sensors

2015

Abstract Random Telegraph Signal (RTS) is a well-known source of noise in current submicron circuits. Its static effects have been widely studied and its noise levels are in the order of other noise sources, especially for moderate submicron transistors. Nevertheless, RTS events may produce transients many times larger than the RTS itself, and this problem seems to have not yet been addressed. In this article we present results on the transients produced by RTS events in a smart vision sensor. RTS transients in closed-loop amplifiers can be many times greater than static RTS. The duration of the RTS transient may last for several milliseconds, and can be considered almost stationary for som…