Search results for "Transitional cell"

showing 10 items of 77 documents

Does P-glycoprotein-170 expression predict for chemoresistance in transitional cell carcinoma of the bladder?

2003

Introduction: The glycoprotein P-170, causing drug efflux from the cells, may represent at least one cause of resistance to most drugs used in intravesical chemotherapy of superficial bladder cancer. Materials and Methods: GP-170 was retrospectively assessed in 60 patients affected by superficial transitional cell tumours of the bladder. It was assessed by immunohistochemistry in a semiquantitative way by the intensity of staining and by the percentage of positive cells. Correlation of GP-170 expression with G-grade, T-category, multiplicity, recurrence rate and treatment was investigated. In 44 patients recurrence was analysed in relation to GP-170 basal expression and to its variations. T…

MaleCarcinoma Transitional CellCancer ResearchATP Binding Cassette Transporter Subfamily BBladder carcinomaImmunohistochemistryIntravesical chemotherapySettore MED/24 - UrologiaAdministration IntravesicalUrinary Bladder NeoplasmsOncologyDrug Resistance NeoplasmPredictive Value of TestsGP-170HumansFemaleMDR-1ChemoresistanceGlycoproteinsNeoplasm StagingRetrospective Studies
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Studies on the Intravesical Action of Topically Administered G 3 H-Doxorubicin Hydrochloride in Men: Plasma Uptake and Tumor Penetration

1980

AbstractDoxorubicin hydrochloride has been used for the treatment and prevention of recurrences of transitional cell carcinoma. Ideal indications for the drug and side effects have not been determined. In this regard the penetration of the drug into the bladder wall and the urothelium as a urinary blood barrier is of interest. Using a tritium label we have investigated tumor penetration and transmucosal plasma uptake of doxorubicin hydrochloride after intravesical application in 7 patients with stage A bladder tumors. Of the 7 patients 5 were free of tumor following transurethral resection and 2 had recurrent disease. The patients free of tumor received 40mg. doxorubicin hydrochloride per 3…

MaleDrugmedicine.medical_specialtyPathologyHydrochlorideAdministration TopicalUrologymedia_common.quotation_subjectUrinary systemmedicine.medical_treatmentUrinary BladderUrologychemistry.chemical_compoundHumansMedicineUrotheliumSalinemedia_commonCarcinoma Transitional Cellbusiness.industryPapillary tumorMiddle Agedmedicine.diseaseTransitional cell carcinomaUrinary Bladder NeoplasmschemistryDoxorubicinDoxorubicin HydrochlorideNeoplasm Recurrence LocalbusinessJournal of Urology
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Venous thromboembolism in metastatic urothelial carcinoma or variant histologies: incidence, associative factors, and effect on survival.

2016

Venous thromboembolism (VTE) is common in cancer patients. However, little is known about VTE risk in metastatic urothelial carcinoma or variant histologies (UC/VH). We sought to characterize the incidence, associative factors, including whether various chemotherapy regimens portend different risk, and impact of VTE on survival in metastatic UC/VH patients. Patients diagnosed with metastatic UC/VH from 2000 to 2013 were included in this multicenter retrospective, international study from 29 academic institutions. Cumulative and 6-month VTE incidence rates were determined. The association of first-line chemotherapy (divided into six groups) and other baseline characteristics on VTE were anal…

MaleOncologyCancer Researchmedicine.medical_treatmentDisease030204 cardiovascular system & hematologyDeoxycytidine0302 clinical medicineNeoplasm MetastasisOriginal ResearchIncidenceIncidence (epidemiology)Middle AgedPrognosis3. Good healthOncology030220 oncology & carcinogenesischemotherapy survivalbladder cancerFemaleBufeta -- Càncermedicine.drugAdultmedicine.medical_specialtyMetastatic Urothelial Carcinomavenous thromboembolismAntineoplastic Agents[SDV.CAN]Life Sciences [q-bio]/Cancer03 medical and health sciencesInternal medicineUrothelialmedicineHumansRadiology Nuclear Medicine and imagingcardiovascular diseasesAgedRetrospective StudiesTrombosi -- TractamentGynecologyCisplatinCarcinoma Transitional CellChemotherapyBladder cancerbusiness.industryClinical Cancer ResearchCancermedicine.diseaseequipment and suppliesSurvival AnalysisGemcitabineGemcitabineUrinary Bladder NeoplasmsUrothelial;Cisplatinbusiness
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Second-Line Chemotherapy in Advanced Bladder Cancer

2000

MaleOncologyCarcinoma Transitional Cellmedicine.medical_specialtyClinical Trials Phase I as Topicbusiness.industryUrologyMiddle AgedGenes p53VinblastineSecond line chemotherapyClinical Trials Phase II as TopicMethotrexateUrinary Bladder NeoplasmsDoxorubicinInternal medicineAntineoplastic Combined Chemotherapy ProtocolsAdvanced bladder cancerHumansMedicineFemaleCisplatinbusinessAgedUrologia Internationalis
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Multiple Mucosal Biopsies and Postoperative Urinary Cytology in Patients with Bladder Cancer

1990

Seventy-one patients with bladder tumors of stage Ta, T1 or T2 were studied by bladder mucosal biopsies. In 34 (48%) patients abnormal histology was found in at least one of the biopsies. The occurrence and severity of mucosal abnormalities were related to tumor grade and stage. Urinary cytology after complete tumor resection was positive in 18 of 19 patients with abnormal biopsies and in 6 of 12 patients with normal biopsies. Postoperative urinary cytology seems to be a good indicator for the presence of urothelial atypia.

MalePathologymedicine.medical_specialtyBiopsyUrologyUrinary systemUrinary BladderUrologyCytologyBiopsyAtypiamedicineHumansCarcinoma Transitional CellMucous MembraneUrinary bladderBladder cancermedicine.diagnostic_testbusiness.industryCarcinoma in situMiddle Agedmedicine.diseaseNeck of urinary bladdermedicine.anatomical_structureUrinary Bladder NeoplasmsFemalebusinessCarcinoma in SituEuropean Urology
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Urine cytology, tumour markers and bladder cancer

1998

MalePathologymedicine.medical_specialtyUrologyUrineAntigens NeoplasmBiomarkers TumorHumansMedicineAcidic Fibroblast Growth FactorGrowth SubstancesUrine cytologyCarcinoma Transitional CellBladder cancerUrinary bladdermedicine.diagnostic_testbusiness.industryMedical screeningmedicine.diseaseTumor associated antigenmedicine.anatomical_structureTransitional cell carcinomaUrinary Bladder NeoplasmsBlood Group AntigensFemaleHistopathologybusinessBJU International
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Elective segmental ureterectomy for transitional cell carcinoma of the ureter: Long-term follow-up in a series of 73 patients

2012

What's known on the subject? and What does the study add? Upper Urinary Tract (UUT) Transitional Cell Carcinoma (TCC) is an uncommon disease and represents approximately 5% of all urothelial carcinomas. We report our series on 73 patients treated with Kidney Sparing Surgery for UUT TCC. Good results have been achieved in terms of oncological outcome comparing this conservative approach to the radical nephrourectomy. OBJECTIVES: • To report the long-term oncological outcome in patients with transitional cell carcinoma of the ureter electively treated with kidney-sparing surgery. • To compare our data with the few series reported in the literature. PATIENTS AND METHODS: • We considered 73 pat…

MaleTime FactorsTime FactorBiopsyUrologyConservative treatment; Segmental ureterectomy; Transitional cell carcinoma; Upper urinary tract; Ureter; Aged; Aged 80 and over; Biopsy; Carcinoma Transitional Cell; Elective Surgical Procedures; Female; Follow-Up Studies; Humans; Italy; Male; Middle Aged; Prospective Studies; Survival Rate; Time Factors; Treatment Outcome; Ureter; Ureteral Neoplasms; Ureteroscopy; Urologic Surgical Procedures; UrologyFollow-Up StudieTransitional cell carcinoma80 and overUreteroscopyHumansProspective StudiesAgedAged 80 and overCarcinoma Transitional CellElective Surgical ProcedureUreteral NeoplasmsCarcinomaMiddle AgedUreteral NeoplasmSurvival RateConservative treatment; Segmental ureterectomy; Transitional cell carcinoma; Upper urinary tract; UreterProspective StudieTreatment OutcomeItalyElective Surgical ProceduresUrologic Surgical ProcedureUpper urinary tractUrologic Surgical ProceduresSegmental ureterectomyFemaleTransitional CellUreterConservative treatmentFollow-Up StudiesHuman
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High-Grade T1 on Re-Transurethral Resection after Initial High-Grade T1 Confers Worse Oncological Outcomes: Results of a Multi-Institutional Study

2018

The aim of this multicenter study was to investigate the prognostic impact of residual T1 high-grade (HG)/G3 tumors at re-transurethral resection (TUR of bladder tumor) in a large multi-institutional cohort of patients with primary T1 HG/G3 bladder cancer (BC).

MaleTime Factorsmedicine.medical_treatment:Medicina Básica [Ciências Médicas]Treatment outcomeBladder cancer; High risk; High-grade; Second look resection; Transurethral resection of bladder tumor; Aged; Aged 80 and over; Carcinoma Transitional Cell; Cystectomy; Disease Progression; Disease-Free Survival; Female; Follow-Up Studies; Humans; Male; Middle Aged; Neoplasm Recurrence Local; Prognosis; Progression-Free Survival; Recurrence; Regression Analysis; Time Factors; Treatment Outcome; Urinary Bladder Neoplasms; Urologic Surgical Procedures030232 urology & nephrologySettore MED/24 - Urologia0302 clinical medicineRecurrenceHigh-grade80 and overAged 80 and overTransurethral resection of bladder tumorCARCINOMA TRANSITIONAL CELLHigh riskBladder cancerFollow up studiesMiddle AgedPrognosisProgression-Free Survival3. Good healthScholarshipTreatment OutcomeLocal030220 oncology & carcinogenesisCiências Médicas::Medicina BásicaUrinary Bladder NeoplasmDisease ProgressionRegression AnalysisUrologic Surgical ProceduresFemaleSecond look resectionHumanmedicine.medical_specialtyTime FactorPrognosiUrologyBladder cancer; High risk; High-grade; Second look resection; Transurethral resection of bladder tumorCystectomyRegression AnalysiDisease-Free SurvivalResectionFollow-Up StudieCystectomy03 medical and health sciencesbladder cancer; high risk; high-grade; second look resection; transurethral resection of bladder tumor; aged; aged 80 and over; carcinoma transitional cell; cystectomy; disease progression; disease-free survival; female; follow-up studies; humans; malemedicineHumansProgression-free survivalAgedCarcinoma Transitional CellScience & Technologybusiness.industryGeneral surgeryDisease progressionCarcinomaNeoplasm RecurrenceUrinary Bladder NeoplasmsUrologic Surgical ProcedureTransitional CellTransurethral resection of bladder tumor.Neoplasm Recurrence LocalbusinessFollow-Up Studies
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How to Name Papillary Tumors of the Bladder in Children: Transitional Cell Carcinoma or Papillary Urothelial Neoplasm of Low Malignant Potential?

2015

Urinary bladder malignancies are uncommon in children. Approximately 80 children with papillary carcinoma have been described to date, presenting as papillary neoplasms of both low grade and low stage. On the basis of the 1973 World Health Organization classification, tumors were classified as transitional cell carcinoma of the urinary bladder (TCCB). Owing to more detailed histologic criteria, this term has been replaced by papillary urothelial neoplasm of low malignant potential and low-grade carcinoma of the urinary bladder in the World Health Organization-International Society of Urologic Pathology consensus classification system of urothelial neoplasms 2004. Nevertheless, TCCB still re…

Malemedicine.medical_specialtyPathologyAdolescentUrologyUrologyWorld Health OrganizationWorld healthmedicineCarcinomaHumansStage (cooking)ChildCarcinoma Renal CellPapillary urothelial neoplasm of low malignant potentialCarcinoma Transitional CellUrinary bladderbusiness.industryPapillary Neoplasmmedicine.diseasemedicine.anatomical_structureTransitional cell carcinomaUrinary Bladder NeoplasmsFemalePapillary carcinomaNeoplasm GradingbusinessUrology
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Comparison of enzyme phenotypes in human bladder tumours and experimentally induced hyperplastic and neoplastic lesions of the rat urinary bladder. A…

1988

The expression of a number of enzymes involved in drug metabolism, membrane function etc. was compared in hyperplastic and neoplastic lesions of the rat bladder and in human bladder tumours. Transitional cell carcinomas (TCC) in both rat and Man were characterized by decreased alkaline phosphatase (ALP) and increased gamma-glutamyl transpeptidase (GGT), beta-glucuronidase (beta-G1), succinate dehydrogenase (SD) and glucose-6-phosphate dehydrogenase (G6PD) activities. In addition, binding for antibodies specific for different cytochrome P-450 species (UT50, PB3a, MC1, MC2) and microsomal epoxide hydrolase (mEHb) was elevated in both murine and human tumours. Comparison of the enzyme phenotyp…

Malemedicine.medical_specialtyPathologyUrinary BladderGlucosephosphate DehydrogenaseInternal medicinemedicineAnimalsHumansNeoplastic transformationEnzyme inducerGlucuronidaseCarcinoma Transitional CellUrinary bladderHyperplasiabiologyHistocytochemistrySuccinate dehydrogenasegamma-GlutamyltransferaseHyperplasiamedicine.diseaseAlkaline PhosphataseImmunohistochemistryRats Inbred F344RatsSuccinate DehydrogenaseEndocrinologymedicine.anatomical_structurePhenotypeUrinary Bladder NeoplasmsMicrosomal epoxide hydrolasebiology.proteinImmunohistochemistryDrug metabolismVirchows Archiv. B, Cell pathology including molecular pathology
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