Search results for "Translation"

Completely randomized RRT-connect: A case study on 3D rigid body motion planning

2015

Nowadays sampling-based motion planners use the power of randomization to compute multidimensional motions at high performance. Nevertheless the performance is based on problem-dependent parameters like the weighting of translation versus rotation and the planning range of the algorithm. Former work uses constant user-adjusted values for these parameters which are defined a priori. Our new approach extends the power of randomization by varying the parameters randomly during runtime. This avoids a preprocessing step to adjust parameters and moreover improves the performance in comparison to existing methods in the majority of the benchmarks. Our method is simple to understand and implement. …

Cognitive Translation and Interpreting Studies (CTIS)

2021

On the translation of the three fundamental problems of elastic equilibrium of anisotropic bodies into systems of Fredholm first kind integral equati…

1972

Museums as disseminators of niche knowledge: Universality in accessibility for all

2019

Accessibility has faced several challenges within audiovisual translation Studies and gained great opportunities for its establishment as a methodologically and theoretically well-founded discipline. Initially conceived as a set of services and practices that provides access to audiovisual media content for persons with sensory impairment, today accessibility can be viewed as a concept involving more and more universality thanks to its contribution to the dissemination of audiovisual products on the topic of marginalisation. Against this theoretical backdrop, accessibility is scrutinised from the perspective of aesthetics of migration and minorities within the field of the visual arts in mu…

Impact of hypoxia on chemoresistance of mesothelioma mediated by the proton-coupled folate transporter, and preclinical activity of new anti-LDH-A co…

2020

Abstract Background Expression of proton-coupled folate transporter (PCFT) is associated with survival of mesothelioma patients treated with pemetrexed, and is reduced by hypoxia, prompting studies to elucidate their correlation. Methods Modulation of glycolytic gene expression was evaluated by PCR arrays in tumour cells and primary cultures growing under hypoxia, in spheroids and after PCFT silencing. Inhibitors of lactate dehydrogenase (LDH-A) were tested in vitro and in vivo. LDH-A expression was determined in tissue microarrays of radically resected malignant pleural mesothelioma (MPM, N = 33) and diffuse peritoneal mesothelioma (DMPM, N = 56) patients. Results Overexpression of hypoxia…

Drug delivery of siRNA therapeutics

2020

Small interfering RNA (siRNA) is a class of nucleic acid-based drugs (NABDs) able to block gene expression by interaction with mRNA before its translation [...]

The soluble loop BC region guides, but not dictates, the assembly of the transmembrane cytochrome b6

2017

Studying folding and assembly of naturally occurring α-helical transmembrane proteins can inspire the design of membrane proteins with defined functions. Thus far, most studies have focused on the role of membrane-integrated protein regions. However, to fully understand folding pathways and stabilization of α–helical membrane proteins, it is vital to also include the role of soluble loops. We have analyzed the impact of interhelical loops on folding, assembly and stability of the heme-containing four-helix bundle transmembrane protein cytochrome b6 that is involved in charge transfer across biomembranes. Cytochrome b6 consists of two transmembrane helical hairpins that sandwich two heme mol…

NO-Based Signaling in Plants

2006

In animals, nitric oxide (NO) is an endogenously produced radical involved in cell communication and signal transduction. Its functions in plants are currently being discovered at an unprecedented pace, and insight into NO-derived mechanisms has mainly been gained from research on signal transduction. Numerous studies have firmly placed NO as one component of the signal perception–transduction network that connects plant responses to primary signals, including hormones, elicitors of defence responses or abiotic stresses. Protein kinases and the second messengers Ca 2+, cGMP, and cADPR convey part of the NO signal within cells. Furthermore, NO-based protein modifications are emerging as broa…

"Nobody could sleep with this infernal business on!" : translations of verbal humour in Floyd Gottfredson's Mickey Mouse

2016

Tämä tutkielma käsittelee verbaalisen huumorin kääntämistä sarjakuvissa ja sen aiheuttamia haasteita kääntäjille. Tutkielma keskittyy Mikki Hiiri -sanomalehtisarjakuviin, joiden alkuperäisiä, englanninkielisiä versioita ja suomenkielisiä käännöksiä vertasin. Tavoitteena oli selvittää, mitkä aineistossa esiintyvät verbaalisen huumorin muodot ovat erityisen haastavia mahdollisimman tarkan ja lähdetekstille uskollisen kääntämisen näkökulmasta, ja millaisia käännöstekniikoita suomalaiset kääntäjät näissä tilanteissa käyttivät. Laajemmassa kontekstissa tutkielman tavoitteena oli osaltaan valaista aihetta, jota on tutkittu varsin vähän sarjakuvantutkimuksen alalla. Tutkimusaineistona toimi viisi …

Iron in Translation: From the Beginning to the End

2021

Iron is an essential element for all eukaryotes, since it acts as a cofactor for many enzymes involved in basic cellular functions, including translation. While the mammalian iron-regulatory protein/iron-responsive element (IRP/IRE) system arose as one of the first examples of translational regulation in higher eukaryotes, little is known about the contribution of iron itself to the different stages of eukaryotic translation. In the yeast Saccharomyces cerevisiae, iron deficiency provokes a global impairment of translation at the initiation step, which is mediated by the Gcn2-eIF2α pathway, while the post-transcriptional regulator Cth2 specifically represses the translation of a subgroup of…