Search results for "Transmitter"
showing 8 items of 348 documents
Preclinical progress with CHF2819, a novel orally active acetylcholinesterase inhibitor
2002
(-)-(3aS,8aS,1S)-1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indol-5-ol-2′-ethylphenylcarbamate N-oxide hydrochloride (CHF2819) is a novel, orally active acetylcholinesterase inhibitor (AChEI) for Alzheimer's disease (AD). CHF2819 appears as a selective inhibitor of AChE, being 115 times more potent against this enzyme than butyrylcholinesterase (BuChE). Moreover, CHF2819 appears more selective for inhibiting central (brain) than peripheral (heart) AChE. In vivo studies show that CHF2819 significantly increases acetylcholine (ACh) levels in young adult rat hippocampus in a dose-dependent manner. Moreover, aged animals exhibit a marked increase in hippocampal concentrations of this…
CHF2819: Pharmacological profile of a novel acetylcholinesterase inhibitor
2002
CHF2819 is a novel orally active acetylcholinesterase inhibitor (AChEI) developed for the treatment of Alzheimer's disease (AD). CHF2819 is a selective inhibitor of AChE, it is 115 times more potent against this enzyme than against butyrylcholinesterase (BuChE). Moreover, CHF2819 is more selective for inhibition of central (brain) AChE than peripheral (heart) AChE. In vivo CHF2819, 0.5, 1.5, and 4.5 mg/kg p.o., significantly and in dose-dependent manner increased acetylcholine (ACh) levels in hippocampus of young adult rats. Moreover, aging animals, with lower basal ACh levels than young adult rats, also exhibit a marked increase in hippocampal levels of this neurotransmitter after administ…
Polymorphisms in the Serotonin (5-Hydroxytryptamine (5-HT)) Type 2A Receptor (5-HTR2A) Gene, Other Related Genes and Anthropometry
2012
Serotonin or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter, which helps to regulate many physiological processes such as sleep, appetite, eating disorders, thermoregulation, hormone secretion, mood, anxiety, etc. The serotonin and related genes, such as the 5-HT2A receptor gene (HTR2A), the 5-HT transporter gene (SLC6A4), the 5-HT2C receptor gene (HTR2C), or the 5-HT1A receptor (HTR1A) gene, are re-emerging as powerful candidates for studying the association between food intake and anthropometry. Variations in all of these genes need to be studied to better understand the effects of serotonin and its receptors on anthropometry. The most widely studied polymorphism is the −1438G…
Localization of Multi-Class On-Road and Aerial Targets Using mmWave FMCW Radar
2021
mmWave radars play a vital role in autonomous systems, such as unmanned aerial vehicles (UAVs), unmanned surface vehicles (USVs), ground station control and monitoring systems. The challenging task when using mmWave radars is to estimate the accurate angle of arrival (AoA) of the targets, due to the limited number of receivers. In this paper, we present a novel AoA estimation technique, using mmWave FMCW radars operating in the frequency range 77–81 GHz by utilizing the mechanical rotation. Rotating the radar also increases the field of view in both azimuth and elevation. The proposed method estimates the AoA of the targets, using only a single transmitter and receiver. The measurements are…
Endocannabinoid Role in Synaptic Plasticity and Learning
2009
Endocannabinoids have recently emerged as versatile modulators of synaptic transmission and can act as retrograde neurotransmitters. As they cannot be stored in synaptic vesicles, endocannabinoid signaling is believed to start ‘on-demand,’ via a stimulus-dependent synthesis from membranous precursors at the postsynaptic site. After synthesis, endocannabinoids bind presynaptically to cannabinoid type 1 (CB1) receptors, leading to a short- or long-term suppression of neurotransmitter release. CB1 receptors are present in a plethora of different synaptic connections in the brain. Electrophysiological and behavioral analyses of mutant mice lacking CB1 receptors and of pharmacologically treated …
Operator Revenue Analysis for Device-to-Device Communications Overlaying Cellular Network
2018
Device-to-device (D2D) communications has recently gathered significant research interest due to its efficient utilization of already depleting wireless spectrum. In this article, we considered a scenario where D2D users communicate in the presence of cellular users in an overlay network setup. In order to analyze the revenue of service providers in monetary terms, the paper provides exact expressions of operator profit for both D2D and cellular users. More specifically, we take into account different network parameters including user density, transmit power and channel variations to understand their impact on the total revenue of the operator. Finally, we derive the balancing value of freq…
Effects of Temperature and Humidity on Radio Signal Strength in Outdoor Wireless Sensor Networks
2015
Many wireless sensor networks operating outdoors are exposed to changing weather conditions, which may cause severe degradation in system performance. Therefore, it is essential to explore the factors affecting radio link quality in order to mitigate their impact and to adapt to varying conditions. In this paper, we study the effects of temperature and humidity on radio signal strength in outdoor wireless sensor networks. Experimental measurements were performed using Atmel ZigBit 2.4GHz wireless modules, both in summer and wintertime. We employed all the radio channels specified by IEEE 802.15.4 for 2.4GHz ISM frequency band with two transmit power levels. The results show that changes in …
On the effects of transmit power control on the energy consumption of WiFi network cards
2009
Transmit power control has been largely proposed as a solution to improve the performance of packet radio systems in terms of increased throughput, spatial reuse and battery lifetime for mobile terminals. However, the benefits of transmit power control schemes on these different performance figures may strongly depend on the employed PHY technology and channel access mechanism. In this paper, we focus on the effects of power control on the energy consumption of WiFi network cards. By means of several experimental tests carried out under different operation conditions and modulation schemes, we try to justify why the reduction of the transmission power has a marginal effect on the overall en…