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Ion transport through membranes: A computer experiment

1983

Abstract Gramicidin-A is a linear pentadecapeptide antibiotic, which forms transmembrane channels; these have a number of interesting conductance characteristics [1, 2 and Refs. therein], as for example high specific ion fluxes (a single channel carries about 10 7 sodium ions/sec at 25 °C, 1 M NaCl and 100 mV transmembrane d.d.p.) have a remarkable ion selectivity among the monovalent cations. The permeability ratios with respect to sodium were found to be in following order H + (150) > NH 4 + (8.9) > Cs + (5.8) > Rb + (5.5) > K + (3.9) > Na + (1.0) > Li + (0.33). The channel is impermeable to anions and to divalent cations and it exhibits saturation and maxima in conductance as a function …

chemistry.chemical_classificationTransmembrane channelsAnalytical chemistryKcsA potassium channelConductanceIon Transport ProcessIonDivalentInorganic Chemistrychemistry.chemical_compoundCrystallographychemistryMaterials ChemistryGramicidinPhysical and Theoretical ChemistryIon transporterInorganica Chimica Acta
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