Search results for "Transwell"

showing 2 items of 2 documents

Novel inulin-based mucoadhesive micelles loaded with corticosteroids as potential transcorneal permeation enhancers

2017

In this work a new copolymer of inulin (INU) derivatized with ethylendiamine (EDA) and retinoic acid (RA), named INU-EDA-RA, was synthetized, characterized and employed to produce micelles as carriers for topical administration of corticosteroids for the potential treatment of diseases of posterior eye segment. Spectroscopic analysis confirmed a molar derivatization degree of 11.30 and 4.30% in EDA and RA, respectively. INU-EDA-RA micelles are capable of strong mucoadhesive interactions which result time-independent and stable over time but concentration depending. Moreover micelles are able to encapsulate efficiently from 3 to 13% (w/w) of lipophilic drugs, as dexamethasone, triamcinolone …

DrugTriamcinolone acetonideTranscorneal enhancerCell SurvivalSwineAdministration Topicalmedia_common.quotation_subjectTranswellPharmaceutical ScienceMucoadhesionRetinal Pigment Epithelium02 engineering and technologyOcular disease030226 pharmacology & pharmacyMicellePermeabilityCorneaMice03 medical and health sciences0302 clinical medicineAdrenal Cortex HormonesPolymeric micelleRetinoic acidCell AdhesionMucoadhesionmedicineCorticosteroidAnimalsHumansDissolution testingOcular topical administrationMicellesmedia_commonDrug CarriersChromatographyDose-Response Relationship DrugChemistryInulinGeneral Medicine021001 nanoscience & nanotechnologyPermeability (electromagnetism)Cattle0210 nano-technologyDrug carrierDrug metabolismBiotechnologymedicine.drugEuropean Journal of Pharmaceutics and Biopharmaceutics
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Mucoadhesive micelles based on inulin derivative for ocular release of corticosteroids

2016

Micelle Inulin Ocular Drug Delivery Permeation Enhancer Transwell Corticosteroid
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