Search results for "Traumatic"
showing 10 items of 326 documents
Corrigendum to “Neuromuscular electrophysiological disorders and muscle atrophy in mechanically-ventilated traumatic brain injury patients: New insig…
2019
Lactate and glucose as energy substrates and their role in traumatic brain injury and therapy
2009
Traumatic brain injury is a leading cause of disability and mortality worldwide, but no new pharmacological treatments are clinically available. A key pathophysiological development in the understanding of traumatic brain injury is the energy crisis derived from decreased cerebral blood flow, increased energy demand and mitochondrial dysfunction. Although still controversial, new findings suggest that brain cells try to cope in these conditions by metabolizing lactate as an energy substrate ‘on-demand’ in lieu of glucose. Experimental and clinical data suggest that lactate, at least when exogenously administered, is transported from astrocytes to neurons for neuronal utilization, essential…
Evaluating the citywide Edinburgh 20mph speed limit intervention effects on traffic speed and volume: A pre-post observational evaluation.
2021
Objectives Traffic speed is important to public health as it is a major contributory factor to collision risk and casualty severity. 20mph (32km/h) speed limit interventions are an increasingly common approach to address this transport and health challenge, but a more developed evidence base is needed to understand their effects. This study describes the changes in traffic speed and traffic volume in the City of Edinburgh, pre- and 12 months post-implementation of phased city-wide 20mph speed limits from 2016–2018. Methods The City of Edinburgh Council collected speed and volume data across one full week (24 hours a day) pre- and post-20mph speed limits for 66 streets. The pre- and post-sp…
The Posttraumatic Stress Disorder Factorial Structure: Findings from a Multicultural Sample
2020
Although several studies exploring Posttraumatic Stress Disorder (PTSD) factorial structure have been conducted, few of them have tested the ICD-11 and the DSM-5-based models in samples from low-in...
The lost mother tongue : An interview study with Finnish war children
2015
This article presents the third study of an interview investigation concerning 10 Finnish war children who were evacuated during the World War II to Sweden and who did not return to live in Finland after the war. The focus is on how they remembered or did not remember their early experiences of displacement and on how they expressed thoughts about their childhood and their adult life. We found that all of them as adults still bore signs of trauma. The younger the children were at the time of the evacuation, the more difficult or even impossible it was for them to think or fantasize about the past. It was consequently not possible for them to work through their experiences of loneliness, abs…
Nitric Oxide/Cyclic Guanosine Monophosphate Signaling via Guanylyl Cyclase Isoform 1 Mediates Early Changes in Synaptic Transmission and Brain Edema …
2021
Traumatic brain injury (TBI) often induces structural damage, disruption of the blood-brain barrier (BBB), neurodegeneration, and dysfunctions of surviving neuronal networks. Nitric oxide (NO) signaling has been suggested to affect brain functions after TBI. The NO exhibits most of its biological effects by activation of the primary targets-guanylyl cyclases (NO-GCs), which exists in two isoforms (NO-GC1 and NO-GC2), and the subsequently produced cyclic guanosine monophosphate (cGMP). However, the specific function of the NO-NO-GCs-cGMP pathway in the context of brain injury is not fully understood. To investigate the specific role of the isoform NO-GC1 early after brain injuries, we perfor…
The collaborative outcomes study on health and functioning during infection times in adults (COH-FIT-Adults): Design and methods of an international …
2022
BACKGROUND: . High-quality comprehensive data on short-/long-term physical/mental health effects of the COVID-19 pandemic are needed. METHODS: . The Collaborative Outcomes study on Health and Functioning during Infection Times (COH-FIT) is an international, multi-language (n=30) project involving >230 investigators from 49 countries/territories/regions, endorsed by national/international professional associations. COH-FIT is a multi-wave, on-line anonymous, cross-sectional survey [wave 1: 04/2020 until the end of the pandemic, 12 months waves 2/3 starting 6/24 months threreafter] for adults, adolescents (14-17), and children (6-13), utilizing non-probability/snowball and representative samp…
The lifelong struggle of Finnish World War II veterans.
2014
Objectives: In many countries veterans from World War II are growing old. Research has shown that war experiences continue to impact those who have been involved in war for a long time. The present study targets old injured war veterans from World War II in Finland. The aim of this study was to produce knowledge of the impact of war experiences and injuries on the lifespan of Finnish war veterans.Method: The method used was grounded theory. Data were collected by interviewing 20 aged war veterans in their homes.Results: The analysis resulted in four categories, with also subcategories: (1) lost childhood and youth; (2) war traumas impacting life; (3) starting life from scratch; and (4) find…
Validation of brain extracellular glycerol as an indicator of cellular membrane damage due to free radical activity after traumatic brain injury.
2008
Following severe traumatic brain injury (TBI), increasing oxygen delivery to the brain has been advocated as a useful strategy to reverse mitochondrial dysfunction and improve neurological outcome. However, this might also promote overproduction of free radicals, responsible for lipid peroxidation and hence brain cell damage. Therefore, a method for monitoring this potential adverse effect in humans is desirable. Glycerol, an end product of phospholipid breakdown, easily detectable in the human brain by means of microdialysis, might represent a reliable indicator of free radical-induced cell membrane damage. Brain microdialysates were collected from 24 adult male Sprague-Dawley rats over a …
Efecto del pedaleo de brazos sobre el sistema cardiorrespiratorio de las personas con tetraplejia. (Effect of armcrank pedaling on the cardiorespirat…
2010
Objetivos: Determinar el efecto de un programa de entrenamiento de pedaleo de brazos (PB) estacionario, sobre el sistema cardiorrespiratorio de personas con tetraplejia. Metodo: Se estudiaron 11 participantes con tetraplejia por lesion medular (LM) de origen traumatico a niveles entre C4 y C6. Se midieron variables espirometricas (VC, FVC y MVV) y de Variabilidad de la Frecuencia Cardiaca VFC (HR, STDHR, RMSSD, LF, HF y HRVPOWER), antes y despues de 8 semanas de entrenamiento. Resultados: Todas las variables mostraron cambios significativos (p < 0,05) despues del programa de entrenamiento aumentando su valor, excepto la FC que disminuyo. Las personas con las LM mas bajas mostraron valores m…