Search results for "Treatment plan"
showing 10 items of 132 documents
Minimizing membrane bioreactor environmental footprint by multiple objective optimization.
2020
This paper presents a modelling study aimed at minimizing the environmental foot print of a membrane bioreactor (MBR) for wastewater treatment. Specifically, an integrated model for MBR was employed in view of the management optimization of an MBR biological nutrient removal (BNR) pilot plant in terms of operational costs and direct greenhouse gases emissions. The influence of the operational parameters (OPs) on performance indicators (PIs) was investigated by adopting the Extended-FAST sensitivity analysis method. Further, a multi-objective analysis was performed by applying the Technique for Order of Preference by Similarity to Ideal Solution (TOPSIS). The results show-up that the sludge …
High Prevalence of Human-Associated Escherichia coli in Wetlands Located in Eastern France
2020
International audience; Escherichia coli that are present in the rivers are mostly brought by human and animal feces. Contamination occurs mostly through wastewater treatment plant (WWTP) outflows and field amendment with sewage sludge or manure. However, the survival of these isolates in river-associated wetlands remains unknown. Here, we assessed E. coli population structure in low-anthropized wetlands located along three floodplains to identify the major source of contamination of wetlands, whose functioning is different from the rivers. We retrieved 179 E. coli in water samples collected monthly from 19 sites located in eastern France over 1 year. Phylogroups B1 and B2 were dominant in …
Calculation of bone graft volume using 3D reconstruction system.
2010
Objectives: To obtain bone ?bioreplicas? for determining precisely the amount of biomaterial required for bone regeneration procedure. Study design: A case-control comparison with a total sample size of 20 cases, 10 control and 10 test samples. ?Bioreplicas? were generated from helical CAT scans with 0.5 mm slices, without 3D reconstruction or image filters. Bone defects in premolar and molar areas were treated with titanium mesh and xenograft (MP3) combined with resorbable carriers. Time taken to carry out procedures with and without the use of ?bioreplicas? (in minutes), discrepancies between the grafts performed with and without ?bioreplicas? and bone defects (mm), and postoperative comp…
Skillful management of exodontia complication to prevent dreadful sequelae
2011
Successful surgical treatments depend upon accurate diagnosis, judicious treatment planning, selection and execution of an appropriate surgical technique, and on a well monitored post-operative period. However, despite these precautions, extraction of teeth (particularly third molar) is exposed to the accidents and complications common to all buccomaxillary and facial interventions. A maxillary third molar may be displaced in maxillary sinus, nearby soft tissue, or may migrate in a superioposterior direction towards paraphyrangeal space, or infratemporal fossa. Dislocating the maxillary third molar in infratemporal fossa is one of the worst nightmare as this area has complex anatomy consist…
Boron determination in liver tissue by combining quantitative neutron capture radiography (QNCR) and histological analysis for BNCT treatment plannin…
2011
The typical primary malignancies of the liver are hepatocellular carcinoma and cholangiocarcinoma, whereas colorectal liver metastases are the most frequently occurring secondary tumors. In many cases, only palliative treatment is possible. Boron neutron capture therapy (BNCT) represents a technique that potentially destroys tumor tissue selectively by use of externally induced, locally confined secondary particle irradiation. In 2001 and 2003, BNCT was applied to two patients with colorectal liver metastases in Pavia, Italy. To scrutinize the rationale of BNCT, a clinical pilot study on patients with colorectal liver metastases was carried out at the University of Mainz. The distribution o…
EPR/alanine dosimetry for two therapeutic proton beams
2016
Abstract In this work the analysis of the electron paramagnetic resonance (EPR) response of alanine pellets exposed to two different clinical proton beams employed for radiotherapy is performed. One beam is characterized by a passive delivery technique and is dedicated to the eyes treatment (OPTIS2 beam line). Alanine pellets were irradiated with a 70 MeV proton beam corresponding to 35 mm range in eye tissue. We investigated how collimators with different sizes and shape used to conform the dose to the planned target volume influence the delivered dose. For this purpose we performed measurements with varying the collimator size (Output Factor) and the results were compared with those obtai…
Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immunotherapy for the treatment of hepatocellular carcinoma.
2021
Patients with advanced hepatocellular carcinoma (HCC) have historically had few options and faced extremely poor prognoses if their disease progressed after standard-of-care tyrosine kinase inhibitors (TKIs). Recently, the standard of care for HCC has been transformed as a combination of the immune checkpoint inhibitor (ICI) atezolizumab plus the anti-vascular endothelial growth factor (VEGF) antibody bevacizumab was shown to offer improved overall survival in the first-line setting. Immunotherapy has demonstrated safety and efficacy in later lines of therapy as well, and ongoing trials are investigating novel combinations of ICIs and TKIs, in addition to interventions earlier in the course…
Review of clinical brachytherapy uncertainties: Analysis guidelines of GEC-ESTRO and the AAPM
2014
Background and purpose: A substantial reduction of uncertainties in clinical brachytherapy should result in improved outcome in terms of increased local control and reduced side effects. Types of uncertainties have to be identified, grouped, and quantified. Methods: A detailed literature review was performed to identify uncertainty components and their relative importance to the combined overall uncertainty. Results: Very few components (e.g., source strength and afterloader timer) are independent of clinical disease site and location of administered dose. While the influence of medium on dose calculation can be substantial for low energy sources or non-deeply seated implants, the influence…
Three-dimensional conformal radiotherapy in localized carcinoma of prostate: preliminary reports of toxicity in dose-escalation treatment
2007
Purpose Many studies confirmed the evidence of a dose-response relationship in prostate cancer. Escalation of dose using conventional techniques is however limited by rectal tolerance. IMRT and 3D-CRT have been designed to allow dose escalation while not exceeding rectal tolerance. We evaluated the acute and early late tolerance to surrounding organs upon dose escalation from 70 to 78 Gy in 3D-CRT setting, in order to introduce the IMRT process as a routine practice in prostate cancer treatment. Materials and Methods We compared clinical data from 35 patients with localized adenocarcinoma of the prostate, who received 70 Gy within a traditional reconstructed three-dimensional treatment plan…
Influence of Three-dimensional Imaging on Implant Treatment Planning: Implant Diameter and Length
2018
Aim To investigate the influence of the radiographic modalities panoramic radiography (PR) and cone beam computed tomography (CBCT) on selection of implant length and diameter. Materials and methods Potential implant sites (59 sites, 40 patients) with available PRs and CBCTs were selected from the databases of two University dental schools. Six experienced clinicians were asked to select the appropriate implant length and diameter based on PR and CBCT. Results were compared with the actual surgical procedure and intra- /interrater agreement was calculated using Cohen's kappa. Results On average, greater implant length was more often planned based on PR (24.2 vs 8.8% with CBCT), while wider …