Search results for "Treme"

showing 10 items of 356 documents

Gozos a nuestra Señora del Tremedal, aparecida y venerada en el monte de Origüela, Reyno de Aragon, Obispado de Albarracin : Diferentes ... Obispos…

1750

El full orlat Grav. xil. enmarcat de "N. S. del Tremedal", flanquejat per gerros amb flors El text del goig a tres col. separades per filets

Nuestra Señora del Tremedal GoigsDevocions populars Oriola del Tremedal (Aragó)Mare de Déu Goigs
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Gozos a nuestra Señora del Tremedal, aparecida y venerada en el monte de Origüela, Reyno de Aragon, Obispado de Albarracin : Diferentes ... Obispos c…

El full orlat Grav. xil. enmarcat de "N. S. del Tremedal", flanquejat per gerros amb flors El text del goig a tres col. separades per filets

Nuestra Señora del Tremedal GoigsDevocions populars Aragó Oriola del TremedalMare de Déu Goigs
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A novel method based on augmented Markov vector process for the time-variant extreme value distribution of stochastic dynamical systems enforced by P…

2020

Abstract The probability density function (PDF) of the time-variant extreme value process for structural responses is of great importance. Poisson white noise excitation occurs widely in practical engineering problems. The extreme value distribution of the response of systems excited by Poisson white noise processes is still not yet readily available. For this purpose, in the present paper, a novel method based on the augmented Markov vector process for the PDF of the time-variant extreme value process for a Poisson white noise driven dynamical system is proposed. Specifically, the augmented Markov vector (AMV) process is constructed by combining the extreme value process and its underlying…

Numerical AnalysisMarkov chainDynamical systems theoryComputer scienceApplied MathematicsProbability density functionWhite noisePoisson distribution01 natural sciencesStochastic dynamic system010305 fluids & plasmassymbols.namesakeAugmented Markov vector proceJoint probability distributionModeling and Simulation0103 physical sciencesPoisson white noise excitationsymbolsGeneralized extreme value distributionApplied mathematicsSettore ICAR/08 - Scienza Delle Costruzioni010306 general physicsExtreme value theoryTime-variant extreme value processCommunications in Nonlinear Science and Numerical Simulation
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Cultural institutions as agents of urban and community regeneration in the (post-)pandemic city. The case of the «Laboratorio Zen Insieme» in Palermo

2022

Although all cities in the world have been affected by the COVID-19 pandemic, its impacts on the territories, yet to be understood, are unevenly distributed, revealing extremely varied imbalances depending on the places. However, it is clear that the virus and its variants have aggravated pre-existing socio-spatial inequalities, creating new ones and bringing attention back to those implications between space, planning, public health and citizenship that are at the origins of contemporary urbanism. In a reference framework in which the crisis is globalized but unequal and in the absence of a welfare system capable of responding to the urgencies of the most marginalized social contexts and g…

Olsen 2018Settore ICAR/21 - UrbanisticaSettore M-GGR/01 - GeografiaSacco and Blessi 2009). In the current (post-) pandemic context and through the lens of a southern European perspective the purpose of this article is to critically reflect about the role of culture as possible vehicle of urban and community regeneration. In particular we will focus on the activities of the no profit organization «Laboratorio Zen Insieme» in ZEN2 one of the last large popular and peripheral neighborhoods built in Palermo at the end of 80s in order to explore and understand how cultural practices work as agent of urban and social transformation capable of addressing emerging issues especially in the pandemic scenario we are experiencing. Thecasestudy has been conducted through analysis of documents participative observations (Honer and Hitzler 2015) and qualitative in-depth interviews with key actors involved in the conception organization and management of the activities carried out by Laboratorio Zen Insieme with representatives of local institutions and non-formal conversations with participants of the workshops heldin the neighborhood. The experience we narrate finds that cultural practices have re-conceptualized their design and functions as strategies of urban and community regeneration and at the same time have contributed to answer to emergent issues in developing proximity and local based strategies facing up to problems inherent civil rights educationalpoverty socio-spatial justice and have changed the image and identity of urban places they inhabit.In this sense the research provides a framework for development of strategies and legitimization for cultural practices and a point of discussionabouttheirrolein urban development.Although all cities in the world have been affected by the COVID-19 pandemic its impacts on the territories yet to be understood are unevenly distributed revealing extremely varied imbalances depending on the places. However it is clear that the virus and its variants have aggravated pre-existing socio-spatial inequalities creating new ones and bringing attention back to those implications between space planning public health and citizenship that are at the origins of contemporary urbanism. In a reference framework in which the crisis is globalized but unequal and in the absence of a welfare system capable of responding to the urgencies of the most marginalized social contexts and groups a response to the new social and individual needs has been offered by cultural institutions that play a role of territorial agency often independently or in the absence of political institutions. Far from the idea of entertainment and divertissement it is in fact increasingly clear how the practices of cultural innovation experimenting with various forms of action and participation can in some cases play a fundamental role in the processes of social cohesion and community building representing an antidote to the worsening of the phenomena of marginalization and socio-spatial inequalities within cities and territories (Colantonio and Dixon 2011
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In the literature: October 2020.

2020

Immune checkpoint inhibitors are widely used as treatment for an increasing number of solid tumours. Nevertheless, the lack of predictive biomarker represents a limitation across several cancer types. During the last years, the possibility to dynamically study tumour evolution through circulating tumour DNA (ctDNA) in plasma has opened novel possibility in evaluating disease status and therapeutic response, especially in localised disease to predict the possibility of relapse. However, the specific opportunities for application in the context of immunotherapy remain to be clarified.1 In an article recently published in Cancer Discovery by Zhang et al ,2 a comprehensive analysis of ctDNA dat…

OncologyCancer Researchmedicine.medical_specialtyPrognostic variableDurvalumabbusiness.industryCancerMicrosatellite instabilityContext (language use)DiseaseNewsmedicine.diseaselcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogenslcsh:RC254-282not applicableOncologyInternal medicinemedicine1506Lung cancerbusinessTremelimumabmedicine.drugESMO open
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PRODIGE 59-DURIGAST trial: A randomised phase II study evaluating FOLFIRI + Durvalumab ± Tremelimumab in second-line of patients with advanced gastri…

2021

International audience; Gastric or gastro-oesophageal junction (GEJ) adenocarcinomas present poor overall survival (OS). First-line chemotherapy regimen for patients with HER2-negative tumours is based on a doublet or triplet of fluoropyrimidine plus platinum salt ± taxane. Second-line chemotherapy (Docetaxel or Irinotecan) improves OS which nonetheless remains poor (around 5 months). The first results of immune checkpoint inhibitors (anti-PD-1) combined with chemotherapy in metastatic gastric and GEJ cancers were discordant in recent phase III trials. Data on dual-blockade (anti-PD-L1 or anti-PD-1 plus anti-CTLA-4) plus chemotherapy are lacking. DURIGAST is a randomised, multicenter, non-c…

OncologyMalemedicine.medical_specialtyDurvalumabEsophageal NeoplasmsLeucovorinPhases of clinical research[SDV.CAN]Life Sciences [q-bio]/CancerAdenocarcinomaAntibodies Monoclonal Humanized03 medical and health sciencesImmune checkpoint inhibitors0302 clinical medicine[SDV.CAN] Life Sciences [q-bio]/CancerStomach NeoplasmsInternal medicineAntineoplastic Combined Chemotherapy ProtocolsmedicineHumansChemotherapyTaxaneHepatologybusiness.industryGastroenterologyAntibodies Monoclonal[SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and GastroenterologyChemotherapy regimen[SDV.MHEP.HEG] Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology3. Good healthIrinotecanTreatment OutcomeDocetaxel030220 oncology & carcinogenesisFOLFIRI030211 gastroenterology & hepatologyCamptothecinFemaleEsophagogastric JunctionFluorouracilFrancebusinessGastric cancerTremelimumabmedicine.drug
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Role of Immunotherapy in the Management of Hepatocellular Carcinoma: Current Standards and Future Directions

2020

The multikinase inhibitor sorafenib was the only approved systemic therapy in advanced hepatocellular carcinoma (HCC) for about a decade. In recent years, the number of approved agents has increased significantly as a result of a number of positive phase iii clinical trials. Lenvatinib as a first-line treatment, and regorafenib, cabozantinib, and ramucirumab in the second-line setting are now approved by the U.S. Food and Drug Administration (FDA) and the European Medicines Agency. In phase II studies, immunotherapy with nivolumab and monotherapy using pembrolizumab yielded impressive results for overall survival in therapy-naïve and pretreated patients, leading to the accelerated approval …

OncologySorafenibmedicine.medical_specialtyCarcinoma HepatocellularCabozantinibHepatocellular carcinomadurvalumabIpilimumabReview ArticlePembrolizumabRamucirumab03 medical and health scienceschemistry.chemical_compoundtremelimumab0302 clinical medicineRegorafenibInternal medicinemedicineHumans030212 general & internal medicineipilimumabClinical Trials as Topicbusiness.industryLiver NeoplasmsSorafenibdigestive system diseasesUnited StatesNivolumabchemistry030220 oncology & carcinogenesispembrolizumabImmunotherapyNivolumabLenvatinibbusinesscheckpoint inhibitorsmedicine.drugCurrent Oncology
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A Douglas–Rachford method for sparse extreme learning machine

2019

Operator splittingSparse regularizationAlgorithmExtreme learning machineMathematicsMethods and Applications of Analysis
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Three-dimensional characterization of extreme ultraviolet mask blank defects by interference contrast photoemission electron microscopy

2008

A photoemission electron microscope based on a new contrast mechanism "interference contrast" is applied to characterize extreme ultraviolet lithography mask blank defects. Inspection results show that positioning of interference destructive condition (node of standing wave field) on surface of multilayer in the local region of a phase defect is necessary to obtain best visibility of the defect on mask blank. A comparative experiment reveals superiority of the interference contrast photoemission electron microscope (Extreme UV illumination) over a topographic contrast one (UV illumination with Hg discharge lamp) in detecting extreme ultraviolet mask blank phase defects. A depth-resolved det…

Optics and PhotonicsMaterials scienceLightUltraviolet Raysbusiness.industryMicroscopy UltravioletExtreme ultraviolet lithographyEquipment DesignBlankDark field microscopyAtomic and Molecular Physics and Opticslaw.inventionMicroscopy ElectronPhotoemission electron microscopyWavelengthOpticslawExtreme ultravioletMicroscopyOptoelectronicsMicroscopy InterferencePhotolithographybusinessOptics Express
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A composite study on the structure and formation of ozone miniholes and minihighs over central Europe

2005

[1] Two different mechanisms have been proposed to be important for the formation of extreme total ozone events in mid-latitudes, so-called miniholes: (A) far-range meridional transport of air masses from regions with different climatological ozone mixing ratios, and (B) (local) adiabatic vertical displacement of isentropes. Here, the relative importance of these two mechanisms is studied using two different ozone profile reconstruction techniques for all miniholes and minihighs (events with anomalously high ozone) during the time period 1980–1989 over Switzerland. Composites for the two types of events of their vertical potential vorticity (PV) reveal a vertical dipole structure of PV anom…

OzoneMeteorologyZonal and meridionalAtmospheric scienceschemistry.chemical_compoundGeophysicschemistryPotential vorticityMiddle latitudesMixing ratioGeneral Earth and Planetary SciencesEnvironmental scienceVertical displacementExtreme value theoryStratosphereGeophysical Research Letters
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