Search results for "Trial"
showing 10 items of 10525 documents
MINIMIZING INFLIXIMAB TOXICITY IN THE TREATMENT OF INFLAMMATORY BOWEL DISEASE
2008
Abstract Background Infliximab is a widely used biological agent for the treatment of inflammatory bowel disease, and has a favorable risk/benefit ratio. Aim It is useful to know that patients treated with infliximab are exposed to developing adverse events that could be reduced with a prudent and a rational clinical approach and by optimizing the treatment protocol. Methods PubMed (including Epub) was searched in October 2006 and again in March 2007. Results The high immunogenic potential of infliximab determines the antibodies that inhibit the effect of infliximab and the appearance of subsequent acute and delayed infusion reactions. Infliximab has an immunomodulatory effect, thus increas…
Kinetic Analysis: A Sensitive Outcome Objective Measurement Method in Evaluating Lateral Patellar Instability
2011
There are many diagnostic clinical tests (e.g., apprehension patellar test or the moving patellar apprehension test), outcome measures (general health and knee scales [IKDC form, Kujala scale, Fulkerson scale, Lysholm knee scoring scale, Tegner activity level scale, short form-36]), and instrumented measurements of patellar mobility (static stability), to assess lateral patellar instability.7,10,15,16 However, according to Smith and colleagues,15 the sensitivity/specificity – reliability/validity of such tests and outcome tools remain unclear for this patient population. These authors conclude that further work is needed to assess the appropriateness of these tests and outcomes.15Moreover, …
Exercise for bone and cartilage in postmenopausal women with mild knee osteoarthritis
2016
The purpose of this study was to investigate the effects of high-impact exercise on bone mineral mass and strength, and on knee cartilage composition in postmenopausal women with mild knee osteoarthritis (OA). In addition, the association between knee OA and femoral neck bone structural characteristics in women with mild knee radiographic OA and those without radiographic knee OA was studied. Also, the reproducibility of measuring human knee joint cartilage by the delayed gadolinium-enhanced MRI (dGEMRIC) technique was determined in healthy asymptomatic subjects. Data from a 12-month randomized controlled trial (RCT) was used to assess the effects of exercise on bones and cartilages. The tr…
I musei naturalistici come presidi ambientali e culturali. L'Orto botanico di Palermo
2013
La funzione degli Orti botanici, fondamentalmente, si esplica nella conservazione, nella ricerca scientifica, nelle attività espositive ed educative. I punti di forza dell’azione sociale di questi tipi di musei deriva sia dalla capacità di produrre e diffondere la conoscenza scientifica, sia dalla ricchezza patrimoniale posseduta. Una serie di emergenze planetarie e le prospettive incerte per l’ambiente, le società, le economie di tutte le nazioni del mondo configurano lo scenario d’oggi. Questa situazione richiede la costruzione collettiva di nuove forme di sentire, pensare e agire nella ricerca di soluzione ai problemi contemporanei. Si tratta quindi, per i musei scientifici, di intrapren…
Music Cities. Estrategias para el desarrollo de la economía de la música
2016
El concepto de Music City está adquiriendo relevancia paralelamente al interés sobre el impacto económico de la cultura, especialmente del sector musical comercial, y su creciente importancia en la planificación urbanística. Con la política local y regional postcrisis en el punto de mira, la gestión cultural apoyada en una investigación apropiada posibilita el desarrollo de una estrategia musical que aproveche los recursos creativos e industriales del territorio. Coordinando a las instituciones públicas, la iniciativa privada y la ciudadanía, esta especialización estratégica genera beneficios transversales para la ciudad, aumentando también su atractivo para visitantes y residentes. The con…
MDS-191: Long-Term Efficacy and Safety of Luspatercept in Lower-Risk Myelodysplastic Syndromes (MDS): Phase 2 PACE-MDS Study
2020
Background: Luspatercept, a first-in-class erythroid maturation agent, has been investigated in patients with LR-MDS and ring sideroblasts (RS) (MEDALIST; Fenaux and Platzbecker NEJM 2020) and in an ongoing Phase 3 trial regardless of RS status (COMMANDS, NCT03682536 ). The previously reported Phase 2 trial of luspatercept (Platzbecker Lanc Onc 2017) includes subtypes of LR-MDS with and without RS, regardless of prior ESA exposure, and various EPO levels. Aims: Evaluate the long-term safety and efficacy of luspatercept in LR-MDS. Methods: Patients were IPSS low/int-1, age ≥ 18 years, Hgb NCT01749514 ; NCT02268383 ). Results: As of 13July2019, 115 patients were enrolled, of whom 108 were tre…
Effects of Coenzyme Q10 on Statin-Induced Myopathy
2015
Abstract Objective To evaluate the efficacy of coenzyme Q10 (CoQ10) supplementation on statin-induced myopathy. Participants and Methods We searched the MEDLINE, Cochrane Library, Scopus, and EMBASE databases (November 1, 1987, to May 1, 2014) to identify randomized controlled trials investigating the impact of CoQ10 on muscle pain and plasma creatine kinase (CK) activity as 2 measures of statin-induced myalgia. Two independent reviewers extracted data on study characteristics, methods, and outcomes. Results We included 6 studies with 302 patients receiving statin therapy: 5 studies with 226 participants evaluated the effect of CoQ10 supplementation on plasma CK activity, and 5 studies (4 u…
Analysis of vitamin D levels in patients with and without statin-associated myalgia — A systematic review and meta-analysis of 7 studies with 2420 pa…
2014
article i nfo Introduction: VitaminD (vitD)deficiencymay beassociatedwith anincreased riskof statin-related symptomatic myalgia in statin-treated patients. The aim of this meta-analysis was to substantiate the role of serum vitamin D levels in statin-associated myalgia. Methods: The search included PUBMED, Cochrane Library, Scopus, and EMBASE from January 1, 1987 to April 1, 2014 to identify studies that investigated the impact of vit D levels in statin-treated subjects with and without myalgia. Two independent reviewers extracted data on study characteristics, methods and outcomes. Quantita- tive data synthesis was performed using a fixed-effect model. Results: The electronic search yielde…
Abstract 18967: Analysis of Vitamin D Levels in Patients With and Without Statin-induced Myalgia - A Systematic Review and Meta-analysis of 7 Studies…
2014
Introduction: Vitamin D (vit D) deficiency may be associated with an increased risk of statin-related muscle complaints, and symptomatic myalgia in statin-treated patients. Hypothesis: The aim of this meta-analysis was to investigate whether subjects with statin-induced myalgia have lower serum vit D levels compared with those who are asymptomatic. Methods: We searched PubMed, Web of Science, Cochrane Library, Scopus and EMBASE (up to March 2014) to identify studies that investigated the impact of vit D levels in statin-treated subjects with and without myalgia. Two independent reviewers extracted data on study characteristics, methods and outcomes. Results: The electronic search yielded 4…
Mycelium Growth and Biological Efficiency of Ganoderma lucidum on Substrate Supplemented with Different Organic Additives
2015
Ganoderma lucidum (W. Curt.: Fr) P. Karst. is a mushroom exhibiting various medicinal properties, popular particularly in Asia. It is grown on a substrate based on hardwood sawdust. Other organic materials, usually agricultural or industrial waste supplemented with various additives, are also used in the cultivation of this mushroom. Numerous studies have shown that the composition of the substrate has a significant effect on mycelium growth and biological efficiency of Reishi mushroom. The presented analysis determined the effect of different organic substances on mycelium growth and biological efficiency of several G. lucidum isolates (Gan 18, Gan Li 27/3, Gan 7, Gan 112) obtained from mu…