Search results for "Trial"
showing 10 items of 10525 documents
Inhibition of Rac1 signaling by lovastatin protects against anthracycline-induced cardiac toxicity
2011
Normal tissue damage limits the efficacy of anticancer therapy. For anthracyclines, the clinically most relevant adverse effect is cardiotoxicity. The mechanisms involved are poorly understood and putative cardioprotectants are controversially discussed. Here, we show that the lipid-lowering drug lovastatin protects rat H9c2 cardiomyoblasts from doxorubicin in vitro. Protection by lovastatin is related to inhibition of the Ras-homologous GTPase Rac1. It rests on a reduced formation of DNA double-strand breaks, resulting from the inhibition of topoisomerase II by doxorubicin. Doxorubicin transport and reactive oxygen species are not involved. Protection by lovastatin was confirmed in vivo. I…
Preliminary results of studies on radioisotopes activity concentrations in vicinity of cement works
2012
W wielu miejscowościach znajdują się pozostałości po zakładach przemysłowych. Nawet jeśli taki teren został zrekultywowany, często obszary położone nieco dalej nie zostały przywrócone do pierwotnego stanu. Na takich terenach można spodziewać się istnienia podwyższonych stężeń różnych pierwiastków, w tym izotopów promieniotwórczych. Do badań pobrano próbki gleby na obszarze byłej cementowni „Piast”, znajdującej się w granicach miasta Opola oraz na obszarze pobliskich ogródków działkowych. W badanych próbkach stwierdzono obecność naturalnych izotopów promieniotwórczych oraz 137Cs. Największe aktywności wykazywały 40K oraz 137Cs. Aktywności naturalnych izotopów promieniotwórczych były znacznie…
Automated Railway Signs Detection. Preliminary Results
2019
Abstract Nowadays safety in railways is mostly achieved by automated system technologies such as ERTMS/ETCS. Nevertheless, on local railways (suburban and regional lines) several tasks still depend on the choices and actions of a human crew. With the aim to improve safety in such type of railways, this research proposes a system for the automatic detection and recognition of railway signs by means of the digital image processing technique. First field applications, carried out on the Italian railway network, show that the proposed system is very accurate (the percentage of correctly detected railway signs is about 97%), even at high train speeds.
Performance Dissimilarities in European Union Manufacturing: The Effect of Ownership and Technological Intensity
2021
Our paper addresses the relevance of a set of continuous and categorical variables that describe industry characteristics to differences in performance between foreign versus locally owned companies in industries with dissimilar levels of technological intensity. Including data on manufacturing sector performance from 20 European Union member countries and covering the 2009–2016 period, we used the random forests methodology to identify the best predictors of EU manufacturing industries’ a priori classification based on two main attributes: ownership (foreign versus local) and technological intensity. We found that EU foreign-owned businesses dominate locally owned ones in terms of size, wh…
Improving Scalable K-Means++
2021
Two new initialization methods for K-means clustering are proposed. Both proposals are based on applying a divide-and-conquer approach for the K-means‖ type of an initialization strategy. The second proposal also uses multiple lower-dimensional subspaces produced by the random projection method for the initialization. The proposed methods are scalable and can be run in parallel, which make them suitable for initializing large-scale problems. In the experiments, comparison of the proposed methods to the K-means++ and K-means‖ methods is conducted using an extensive set of reference and synthetic large-scale datasets. Concerning the latter, a novel high-dimensional clustering data generation …
Rationale and design of the DARWIN-T2D (DApagliflozin Real World evIdeNce in Type 2 Diabetes): A multicenter retrospective nationwide Italian study a…
2017
Background Randomized controlled trials (RCTs) in the field of diabetes have limitations inherent to the fact that design, setting, and patient characteristics may be poorly transferrable to clinical practice. Thus, evidence from studies using routinely accumulated clinical data are increasingly valued. Aims We herein describe rationale and design of the DARWIN-T2D (DApagliflozin Real World evIdeNce in Type 2 Diabetes), a multicenter retrospective nationwide study conducted at 50 specialist outpatient clinics in Italy and promoted by the Italian Diabetes Society. Data synthesis The primary objective of the study is to describe the baseline clinical characteristics (particularly HbA1c) of pa…
Eating behavior dimensions and 9-year weight loss maintenance : a sub-study of the Finnish Diabetes prevention study
2023
Abstract Background Behavioral processes through which lifestyle interventions influence risk factors for type 2 diabetes (T2DM), e.g., body weight, are not well-understood. We examined whether changes in psychological dimensions of eating behavior during the first year of lifestyle intervention would mediate the effects of intervention on body weight during a 9-year period. Methods Middle-aged participants (38 men, 60 women) with overweight and impaired glucose tolerance (IGT) were randomized to an intensive, individualized lifestyle intervention group (n = 51) or a control group (n = 47). At baseline and annually thereafter until nine years body weight was measured and the Three Factor Ea…
Antioxidant Therapies and Oxidative Stress in Friedreich´s Ataxia: The Right Path or Just a Diversion?
2020
Friedreich's ataxia is the commonest autosomal recessive ataxia among population of European descent. Despite the huge advances performed in the last decades, a cure still remains elusive. One of the most studied hallmarks of the disease is the increased production of oxidative stress markers in patients and models. This feature has been the motivation to develop treatments that aim to counteract such boost of free radicals and to enhance the production of antioxidant defenses. In this work, we present and critically review those 'antioxidant' drugs that went beyond the disease's models and were approved for its application in clinical trials. The evaluation of these trials highlights some …
In tema di falsità in sigilli e di reati a tutela della proprietà industriale privata, nota alla sentenza della Cassazione, 26 aprile 2006
2007
Valoración actual ecográfica de la receptividad endometrial
2012
El proceso de implantación embrionaria es considerado uno de los pasos más críticos para conseguir el embarazo e implica la coordinación de una serie de complejas interacciones entre el blastocisto en desarrollo y el endometrio materno. Hoy en día se consideran dos factores primordiales en el éxito reproductivo: la calidad ovocitaria y la receptividad endometrial. La evidencia de tasas de embarazo similares entre mujeres de edades diferentes después de tratamientos de reproducción asistida, especialmente cuando se emplean ovocitos donados, sugiere que la calidad del embrión es el factor más determinante del éxito de la implantación. Sin embargo, una proporción significativa de fallos de la …