Search results for "Trial"

Una proiezione spaziale per la musica del nostro tempo

2020

Articolo su una proposta progettuale che, svolta come Tesi di Laurea da Sara Sgueglia (relatore Renato Capozzi e Correlatrice Claudia Sansò), prevede per le tre parti del complesso di Nebida - Il Polo, l’ex laveria La Carroccia e l’Approdo - non solo un cambiamento funzionale, ma una mutazione di senso. Ciò trasforma la preesistenza, un esempio di archeologia industriale ubicata nel lato Ovest della Sardegna, in un luogo per acquisire nuove tecniche di registrazione sonora. Progetto vincitore del premio Camerino 2019. Article on a project proposal that, carried out as a thesis by Sara Sgueglia (rapporteur Renato Capozzi and co-rapporteur Claudia Sansò), foresees for the three parts of the N…

Effect of RNS60 in amyotrophic lateral sclerosis: a phase II multicentre, randomized, double-blind, placebo-controlled trial

2022

Background and purpose: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with limited treatment options. RNS60 is an immunomodulatory and neuroprotective investigational product that has shown efficacy in animal models of ALS and other neurodegenerative diseases. Its administration has been safe and well tolerated in ALS subjects in previous early phase trials. Methods: This was a phase II, multicentre, randomized, double-blind, placebo-controlled, parallel-group trial. Participants diagnosed with definite, probable or probable laboratory-supported ALS were assigned to receive RNS60 or placebo administered for 24 weeks intravenously (375 ml) once a week and via nebul…

EXTRACORPOREAL SHOCK WAVE THERAPY (ESWT) IN CHRONIC LOW BACK PAIN: A SYSTEMATIC REVIEW OF RANDOMIZED CLINICAL TRIALS

2020

Background: Extracorporeal Shock Wave Therapy (ESWT) has become a popular tool to treat musculoskeletal disorders and chronic low back pain. Aim of the study: To review the current scientific literature and assess the utility of ESWT in treating chronic low back pain. Methods: This systematic review was conducted from November 2019 to January 2020. Its purpose was to determine what the effectiveness is of the various forms of ESWT for the treatment of chronic low back pain. The critical review of the literature on the use of ESWT in chronic low back was made using the scientifically recognized medical databases PubMed, MEDLINE, Physiotherapy Evidence Database (PEDro) and Web of Science Core…

ESSAI RANDOMISÉ POUR ÉVALUER L’EFFICACITÉ ET LA SÉCURITÉ DE TRAITEMENTS CHEZ DES PATIENTS AMBULATOIRES ATTEINTS DE COVID-19 AYANT DES FACTEURS DE RIS…

2021

Context. The Covid-19 pandemic is of unprecedented magnitude and has had major social and health consequences. Primary care professionals, mainly general practitioners, ensure the care of most patients with Covid-19. An early-stage treatment administered to patients with risk factors for developing a severe disease could reduce hospitalization and death rates. No treatment is currently validated in this indication. Objectives. To evaluate the safety and efficacy of experimental candidate agents delivered in outpatient settings to reduce the risk of hospitalization or death in at-risk patients with early-stage proven Covid-19 and no indication for hospital admission. Methods. Multicentric, o…

Factorial phase III randomised trial of rofecoxib and prolonged constant infusion of gemcitabine in advanced non-small-cell lung cancer: the GEmcitab…

2007

Optimization of trigeneration systems by Mathematical Programming: influence of plant scheme and boundary conditions

2014

The large potential for energy saving by cogeneration and trigeneration in the building sector is scarcely exploited due to a number of obstacles in making the investment attractive. The analyst often encounters difficulties in identifying optimal design and operation strategies, since a number of factors, either endogenous (i.e. related with the energy load profiles) and exogenous (i.e. related with external conditions like energy prices and support mechanisms), influence the economic viability. In this paper a decision tool is presented, that simultaneously optimizes the plant lay-out, the sizes of the main components and their operation strategy. For a specific building in the hotel sect…

Metabolic Changes in Tumor Microenvironment: How Could They Affect γδ T Cells Functions?

2021

The metabolic changes that occur in tumor microenvironment (TME) can influence not only the biological activity of tumor cells, which become more aggressive and auto sustained, but also the immune response against tumor cells, either producing ineffective responses or polarizing the response toward protumor activity. γδ T cells are a subset of T cells characterized by a plasticity that confers them the ability to differentiate towards different cell subsets according to the microenvironment conditions. On this basis, we here review the more recent studies focused on altered tumor metabolism and γδ T cells, considering their already known antitumor role and the possibility of manipulating th…

Roles of Exogenous Technologies in Vehicle Innovation: Cases from a Japan’s Automotive Parts Manufacturing Firm

2017

This paper explores the roles of technological innovations in the growth of Japan’s motor vehicle industry, mainly from technology spillover perspective from the early 2000s to today. An empirical analysis focusing on business performances, R&D investments, and patent applications taking a noteworthy unique case in Japan was attempted. Empirical analyses on the productivity of patent to technology stock, use of exogenous technologies for their own technological innovation on its Automotive Business Unit elucidated that innovation capabilities, incorporation of exogenous technologies, and profit generation makes a virtuous cycle of continuous technological innovation. Furthermore, we fou…

Oded Ezer, Il mirabolante costruttore di lettere e alfabeti

2008

Tutte le altezze, profondità e larghezze delle cose tangibili e naturali: paesaggi, tramonti, il profumo del fieno, il ronzio delle api, la bellezza che dipende dalle ciglia, ma è erroneamente attribuita agli occhi; tutte le incommensurabili emozioni e tutti i moti dell'animo umano, che paiono senza limiti; cose e pensieri orrendi, terribili e misteriosi, ma anche belli; tutto questo è compreso, contenuto e ordinato in un piccolo guazzabuglio di lettere. Ventisei simboli! Così scriveva nel 1923 Francis Maynell, il tipografo inglese che aveva conquistato il mondo con ventisei soldati di piombo, i quali altri non erano che i caratteri dell'alfabeto necessari alla produzione della Nonesuch Pre…

Inexhaustible creator of letters and alphabets

2009

It really is a shame that the only way to be truly amazed by things that jump off the flat page, or twist and turn, fold, swell up, or create incredible pop-up buildings is to leaf through the pages of children's books, following the adventures of their heroes as they make their way through the fragments of landscapes they are called on to cross, through forests and valleys, in and out of tiny houses, castles and ravines, past dinosaurs and dragons, through ocean beds with octopuses and sperm whales, imaginary spaces. The shapes of the heroes of these tales rise up from the pages of the books they dwell in, like the memory of some unpunished crime, as if they too feel the same strong sense …