Search results for "Trichloroethanes"

showing 3 items of 3 documents

Acute effects of 1,1,1-trichloroethane on human olfactory functioning.

2004

Background Animal experiments indicate that 1,1,1-trichloroethane can cause degeneration of the olfactory epithelium. The effects of 1,1,1-trichloroethane on human odor perception still have not been investigated. The goal of this study was to learn more about acute effects of 1,1,1-trichloroethane. Methods Twelve healthy, nonsmoking students were exposed to 200 and 20 ppm (control) 1,1,1-trichloroethane in an exposure chamber for 4 hours according to a crossover design. Olfactory functioning was investigated with the Sniffin’ Sticks. The test includes the determination of the detection threshold for n-butanol and an odor identification test. Results After 1 hour of exposure to 200 ppm 1,1,…

Olfactory systemAdultMaleOlfactory Nerve040301 veterinary sciencesPhysiologyDegeneration (medical)030226 pharmacology & pharmacySensitivity and SpecificityStatistics Nonparametric0403 veterinary science03 medical and health sciencesOlfactory mucosachemistry.chemical_compoundOlfaction Disorders0302 clinical medicineOlfactory MucosaAdministration InhalationOlfactory thresholdMedicineHumansTrichloroethanesOlfactory memoryProbabilityCross-Over StudiesDose-Response Relationship Drugbusiness.industry04 agricultural and veterinary sciencesCrossover studymedicine.anatomical_structureOtorhinolaryngologychemistry111-TrichloroethaneCase-Control StudiesSensory ThresholdsPerceptionbusinessOlfactory epitheliumAmerican journal of rhinology
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Energetics of conformational conversion between 1,1,2-trichloroethane polymorphs

2008

Pressure-induced transformations between gauche-, gauche+ and transoid conformations have been evidenced by X-ray single-crystal diffraction for 1,1,2-trichloroethane, and the energies of intermolecular interactions, conformational conversion, and the latent heat have been determined.

Diffraction112-TrichloroethaneEnergeticsIntermolecular forceMolecular ConformationMetals and AlloysGeneral ChemistryCrystallography X-RayCatalysisSurfaces Coatings and FilmsElectronic Optical and Magnetic Materialschemistry.chemical_compoundCrystallographychemistryComputational chemistryLatent heatMaterials ChemistryCeramics and CompositesTrichloroethanesChemical Communications
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The exposure of healthy volunteers to 200 ppm 1,1,1-trichloroethane increases the concentration of proinflammatory cytokines in nasal secretions

1999

Objectives: Irritating effects of organic solvents have usually been measured by means of questionnaires. The aim of the present study was to evaluate the sensitivity of different methods of detecting subclinical irritating effects. Methods: Twelve healthy, non-smoking students were exposed to 200 ppm and to 20 ppm 1,1,1-trichloroethane in an exposure chamber, using a crossover design. The amounts of interleukins (IL)-1β, IL-6 and IL-8 and prostaglandin E2 (PGE2) in nasal secretions were measured. Mucociliary transport time was determined with the saccharine test. Ciliary beat frequency of nasal epithelial cells was measured with video-interference contrast microscopy. Subjective symptoms w…

AdultMalemedicine.medical_specialtyMucous membrane of nosemedicine.disease_causeDinoprostoneStatistics NonparametricProinflammatory cytokineInternal medicinemedicineHumansTrichloroethanesProstaglandin E2Subclinical infectionCross-Over StudiesInhalationInterleukin-6ChemistryInterleukinsInterleukin-8Public Health Environmental and Occupational HealthCrossover studyNasal MucosaEndocrinologyMucociliary ClearanceImmunologyToxicitySolventsIrritationInterleukin-1medicine.drugInternational Archives of Occupational and Environmental Health
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