Search results for "Triptòfan"

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Association of Tryptophan Metabolites with Incident Type 2 Diabetes in the PREDIMED Trial: A Case–Cohort Study

2018

Abstract BACKGROUND Metabolites of the tryptophan–kynurenine pathway (i.e., tryptophan, kynurenine, kynurenic acid, quinolinic acid, 3-hydroxyanthranilic) may be associated with diabetes development. Using a case–cohort design nested in the Prevención con Dieta Mediterránea (PREDIMED) study, we studied the associations of baseline and 1-year changes of these metabolites with incident type 2 diabetes (T2D). METHODS Plasma metabolite concentrations were quantified via LC-MS for n = 641 in a randomly selected subcohort and 251 incident cases diagnosed during 3.8 years of median follow-up. Weighted Cox models adjusted for age, sex, body mass index, and other T2D risk factors were used. RESULTS …

Male0301 basic medicinemedicine.medical_specialtyMetaboliteClinical Biochemistry030209 endocrinology & metabolismTriptòfanType 2 diabetesDiet MediterraneanArticleCohort Studies03 medical and health scienceschemistry.chemical_compound0302 clinical medicineKynurenic acidRisk FactorsInternal medicinemedicineHomeostasisHumansDiabetisbusiness.industryDiabetesBiochemistry (medical)Hazard ratioTryptophanTryptophanmedicine.disease030104 developmental biologyEndocrinologyEstudi de casoschemistryDiabetes Mellitus Type 2Case-Control StudiesHomeostatic model assessmentFemaleCase studiesInsulin ResistancebusinessKynurenineQuinolinic acid

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PEPhysical Sciences and Engineering
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LSLife Sciences
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