Search results for "Tropic"
showing 10 items of 1375 documents
Synergistic targeting of FLT3 mutations in AML via combined menin-MLL and FLT3 inhibition
2020
Abstract The interaction of menin (MEN1) and MLL (MLL1, KMT2A) is a dependency and provides a potential opportunity for treatment of NPM1-mutant (NPM1mut) and MLL-rearranged (MLL-r) leukemias. Concomitant activating driver mutations in the gene encoding the tyrosine kinase FLT3 occur in both leukemias and are particularly common in the NPM1mut subtype. In this study, transcriptional profiling after pharmacological inhibition of the menin-MLL complex revealed specific changes in gene expression, with downregulation of the MEIS1 transcription factor and its transcriptional target gene FLT3 being the most pronounced. Combining menin-MLL inhibition with specific small-molecule kinase inhibitors…
Assessment of threat status and management effectiveness in Kakamega Forest, Kenya
2006
To counteract an increasing biodiversity decline, parks and protected areas have been established worldwide. However, many parks lack adequate management to address environmental degradation. To improve management strategies simple tools are needed for an assessment of human impact and management effectiveness of protected areas. This study quantifies the current threats in the heavily fragmented and degraded tropical rainforest of Kakamega, western Kenya. We recorded seven disturbance parameters at 22 sites in differently managed and protected areas of Kakamega Forest. Our data indicate a high level of human impact throughout the forest with illegal logging being most widespread. Furthermo…
New European Discovery of Splachnum pensylvanicum (Bryophyta, Splachnaceae) in Lithuania, with Taxonomic Notes and a Review of Its World Distribution
2021
Splachnum pensylvanicum (Brid.) Grout ex H.A.Crum is recorded for the first time in Lithuania and it is its fourth discovery at a third locality in Europe. It was found for the first time in 2000 in Kamanos mire, the largest peatland complex in the northern part of this East Baltic country. Targeted investigations at this site in 2017 resulted in the discovery of 14 populations and it is apparently the largest and most abundant locality of the species in Europe. Splachnum pensylvanicum is briefly described and illustrated along with some taxonomic notes and a detailed description of its habitat requirements. The global geographical distribution of S. pensylvanicum is reviewed and mapped. It…
Original data for article: From habitat use to social behavior: natural history of a voiceless poison frog, Dendrobates tinctorius
2019
Descriptive studies of natural history have always been a source of knowledge on which experimental work and scientific progress rely. Poison frogs are a well-studied group of small Neotropical frogs with diverse parental behaviors, distinct calls, and bright colors that warn predators about their toxicity; and a showcase of advances in fundamental biology through natural history observations. The dyeing poison frog, Dendrobates tinctorius, is emblematic of the Guianas region, widespread in the pet-trade, and increasingly popular in research. This species shows several unusual behaviors, such as the lack of advertisement calls and the aggregation around tree-fall gaps, which remain poorly d…
The Castniidae (Lepidoptera) in the collection of the Natural History Museum of the Institute of Systematics and Evolution of Animals of the Polish A…
2017
Praca zawiera informacje na temat przedstawicieli rodziny Castniidae znajdujących się w zbiorach Muzeum Przyrodniczego Instytutu Systematyki i Ewolucji Zwierząt Polskiej Akademii Nauk w Krakowie. Łącznie w kolekcji odnaleziono 17 okazów należących do 14 gatunków i podgatunków tej rodziny. Dla każdego z tych taksonów przedstawiono uwagi na temat rozmieszczenia oraz biologii.
Supplementary material 1 from: Pirie MD, Chatrou LW, Maas PJM (2018) A taxonomic revision of the Neotropical genus Cremastosperma (Annonaceae), inclu…
2018
A file incorporating the georeferenced part of this data that can be opened in Google Earth :
Supplementary material 2 from: Pirie MD, Chatrou LW, Maas PJM (2018) A taxonomic revision of the Neotropical genus Cremastosperma (Annonaceae), inclu…
2018
Full tables of Cremastosperma collections data (CSV, XLS and DBF formats) : Data type: occurences
Sodium Fluxes and Astroglial Function
2012
Astrocytes exhibit their excitability based on variations in cytosolic Ca(2+) levels, which leads to variety of signalling events. Only recently, however, intracellular fluctuations of more abundant cation Na(+) are brought in the limelight of glial signalling. Indeed, astrocytes possess several plasmalemmal molecular entities that allow rapid transport of Na(+) across the plasma membrane: (1) ionotropic receptors, (2) canonical transient receptor potential cation channels, (3) neurotransmitter transporters and (4) sodium-calcium exchanger. Concerted action of these molecules in controlling cytosolic Na(+) may complement Ca(2+) signalling to provide basis for complex bidirectional astrocyte…
Model of Rabies Control
1976
Rabies is an infectious disease of warm blooded animals and humans due to a neurotropic virus which is usually spread by the intake of virus contaminated saliva into a wound after the bite of a rabid animal. In the present epidemic of Western Europe which started about 1940 in the East and which shows a tendency of spreaching in a west southwesterly direction — figure 1 — (Kauker, 1975) foxes are the most important carrier of the disease. Rabies virus was isolated during 1975 in the GFR from 5718 animals of which 4l80 (75 percent) were foxes and only 905 domestic animals (474 cattle, 113 dogs, 164 cats, and 154 other domestic animals).
Diversification and community assembly of the world’s largest tropical island
2022
Aim: The species diversity and endemism of tropical biotas are major contributors to global biodiversity, but the factors underlying the formation of these systems remain poorly understood. Location: The world's largest tropical island, New Guinea. Time period: Miocene to present. Major taxa studied: Passerine birds. Methods: We first generated a species-level phylogeny of all native breeding passerine birds to analyse spatial and elevational patterns of species richness, species age and phylogenetic diversity. Second, we used an existing dataset on bill morphology to analyse spatial and elevational patterns of functional diversity. Results: The youngest New Guinean species are principally …