Search results for "Turing"
showing 10 items of 2644 documents
Electrical energy analysis and potential environmental improvements of sheet metal punching processes
2013
Discrete part manufacturing processes, in particular non-conventional production processes, are still poorly documented in terms of environmental footprint. Within the separating processes, sheet metal punching processes have not been analyzed yet from environmental point of view. The present paper aims to contribute to filling this knowledge gap. In particular, two different punching machine tool architectures were analyzed. Following the previously developed CO2PE methodological approach, power studies and a preliminary time study have been performed in order to understand the contribution of each sub-unit towards the total energy demand. The influence of the most relevant process paramet…
Influence of Material-Related Aspectsof Additive and Subtractive Ti-6Al-4VManufacturing on Energy Demandand Carbon Dioxide Emissions
2017
The additive manufacturing of metal parts represents a promising process that could beused alongside traditional manufacturing methods. The research scenario in this field isstill largely unexplored, as far as the technological solutions adopted to integrate differentprocesses are concerned and in terms of environmental and economic impact assessment.In this article, an electron beam melting (EBM) process and a machining process have beenanalyzed and compared using a cradle-to-grave life cycle–based approach. The productionof components made of the Ti-6Al-4V alloy has been assumed as a case study. Theproposed methodology is able to account for all of the main factors of influence on energydem…
Segmented Flow-Based Multistep Synthesis of Cadmium Selenide Quantum Dots with Narrow Particle Size Distribution
2015
A continuous-flow microreactor was used to synthetize II-VI semiconductor quantum dots (CdSe). In order to improve the size distribution of the nanoparticles, the synthesis was carried out in a two-step procedure. A seed solution was obtained in a separate nucleation step, followed by a controllable growth step. Quantum dots that are synthesized with the two-step method show a much narrower size distribution in comparison to those obtained in a conventional batch synthesis.
A first-in-human trial of RG7116, a glycoengineered monoclonal antibody targeting HER3, in patients with advanced/metastatic tumors of epithelial cel…
2013
2522 Background: The Human Epidermal Growth Factor Receptor 3 (HER3) is a key heterodimerization partner for other HER family members thereby acting as a downstream signal amplifier. This is a first in human study evaluating the safety of RG7116, a humanized anti-HER3 monoclonal antibody with potent HER3 signal inhibition. Due to a glycoengineered Fc-part this antibody displays enhanced antibody-dependent cellular cytotoxicity as compared to conventional antibodies. Methods: Patients (pts) with advanced or metastatic carcinomas with centrally confirmed HER3 protein expression were included. A “3+3” dose escalation design was performed starting at 100 mg flat dosing in a q2w regimen. In add…
Experimental assessment of the hydro-mechanical behaviour of a shale caprock during CO2 injection
2021
Abstract The presented experimental study focuses on the hydro-mechanical characterisation of a shale caprock (Opalinus Clay) in contact with carbon dioxide. The objective of this paper, consists in the evaluation of the material's sealing capacity in terms of entry-pressure, mechanical behaviour and sensitivity of the transport properties to chemo-mechanical effects induced by gaseous and liquid CO2 injection. Two types of Opalinus Clay core samples are tested; shaly and carbonate-rich. The sealing capacity has been evaluated on the shaly OPA according to the stepwise and the residual methods and compared to the results from mercury intrusion porosimetry. The obtained results and the diffe…
A novel thermoeconomic analysis under dynamic operating conditions for space heating and cooling systems
2019
Abstract Thermoeconomic analysis allows for a deep understanding of the cost formation process within an energy system, providing insights into the possible routes for improvement. Several thermoeconomic approaches are well-established for application in systems with steady operating conditions, such as power plants, while a limited number of applications to air-conditioning systems in buildings have been proposed, due to the difficulties in dealing with very irregular load profiles and unsteady plant operating conditions. This study investigates the potential of Thermoeconomics as a support for decision making in building energy systems, proving its capability to identify trade-offs betwee…
Reverse electrodialysis heat-engine: Case studies of improving energy efficiency through recovery of low temperature excess heat
2018
Reverse Electrodialysis (RED) is a technology for generating electricity from the difference in salinity between two solutions. RED is usually applied to natural water streams with different salinities, like seawater vs. freshwater. In the RED Heat-to-Power project we explore the option of using artificial water solutions operating in a closed loop where the difference in salinity is regenerated in a separation step powered by heat at temperature ranges between 60 and 100°C. We call this system Reverse Electrodialysis Heat Engine (RED HE). In this paper, first we summarise the possible system configurations and the overall amount of excess heat available in Europe for powering the RED HE pr…
Immediate and long-term microshear bond strength of resin-based cements to core build-up materials
2021
Background To evaluate the microshear bond strength (μ-SBS) between resin-based cements and core build-up materials after water storage. Material and methods Cylinders (1x1 mm) of conventional dual-cure resin cement (RelyX ARC, 3M ESPE), universal dual-cure resin cement (RelyX Ultimate, 3M ESPE) or self-adhesive resin cement (RelyX U200, 3M ESPE) were adhered to disks (6x2 mm) made with commercial core build-up materials (Bis-Core, Bisco or LuxaCore Z, DMG) or conventional nanocomposite resin (Filtek Z350 XT, 3M ESPE). The specimens (n=10) were submitted to μ-SBS test using a universal testing machine and fracture pattern analysis at 48 hours or after 9 months of water storage. The data wer…
Hydration of alite containing aluminium
2011
Abstract The most important phase in Portland cement is tricalcium silicate, which leads during its hydration to the nucleation and growth of calcium silicate hydrate [referred to as C–S–H, (CaO)x–SiO2–(H2O)y]. The development of this hydrate around the cement grains is responsible for the setting and hardening of cement pastes. The general term for designating the tricalcium silicate in cements is alite. This name relates to all polymorphs containing various foreign ions inserted in their structure. These ions may influence the intrinsic reactivity, and once released during the dissolution, they may interact also with C–S–H. One of the most likely species to be inserted in the alite struct…
Assessment of Postharvest Dehydration Kinetics and Skin Mechanical Properties of “Muscat of Alexandria” Grapes by Response Surface Methodology
2016
The dipping of berries in a dilute solution of sodium hydroxide during a short time was evaluated as pretreatment undertaken prior to convective dehydration of wine grapes. The impact of the sodium hydroxide content and dipping time on weight loss (WL) at different dehydration times was thoroughly assessed using central composite design (CCD) and response surface methodology (RSM). Furthermore, the effects of these two variables were also investigated on the skin mechanical properties of dehydrated grapes. The effect of these two pretreatment factors on the dehydration kinetics and skin hardness was satisfactorily fitted to regression models. The berry pretreatment with low sodium hydroxide…