Search results for "Type 1 Diabete"
showing 10 items of 208 documents
Diētas faktoru ietekme uz I tipa cukura diabēta gaitu
2020
1. tipa cukura diabēts ir hroniska, progresējoša autoimūna slimība, kuras beigu posms ir absolūts insulīna deficīts. Ilgstoša nepietiekama hiperglikēmijas kontrole noved pie mikrovaskulārām vai makrovaskulārām komplikācijām. Medicīniskā uztura terapija kopā ar fiziskām aktivitātēm un insulīna terapiju ir 1. tipa cukura diabēta ārstēšanas pamats. Pētījuma mērķis: izpētīt saistību starp diētas skalas izmaiņām un 1. tipa cukura diabēta komplikāciju (kardiovaskulārās patoloģijas, retinopātija, nefropātija) progresiju. Materiāli un metodes: pacientu rekrutēšana „LatDiane” longitudinālam pētījumam notika laika posmā no 2013. gada oktobra līdz 2017. gada jūlijam un kopā pētījumā piedalījās 130 dal…
Recovery of Endogenous β-Cell Function in Nonhuman Primates After Chemical Diabetes Induction and Islet Transplantation
2008
OBJECTIVE—To describe the ability of nonhuman primate endocrine pancreata to reestablish endogenous insulin production after chemical β-cell destruction. RESEARCH DESIGN AND METHODS—Eleven monkeys (Macaca fascicularis) were rendered diabetic with streptozotocin. Eight diabetic monkeys received intraportal porcine islet transplantation. RESULTS—Two monkeys transplanted after 75 days of type 1 diabetes showed recovery of endogenous C-peptide production a few weeks after transplantation, concomitant with graft failure. Histological analysis of the pancreas of these monkeys showed insulin-positive cells, single or in small aggregates, scattered in the pancreas and adjacent to ducts. Interesting…
Personality types in individuals with type 1 and type 2 diabetes
2020
Objective The Type A personality, characterized by impatience, strong career ambition and competitiveness, is associated with greater sensitivity to external stress. Type 1 diabetes (T1D) is an auto-immune disease, which is potentially influenced by stress, unlike type 2 diabetes (T2D). The aim of this study was to assess whether individuals with T1D and T2D exhibited significant differences on the Type A personality scale. We also assessed personality in patients with thyroid auto-immune diseases to validate potential links between auto-immune disease and Type A personality. Design and methods The Bortner questionnaire was used to assess Type A personality in 188 patients with T1D, 430 pa…
Cell Therapy in Type 1 Diabetes
2011
The incidence of diabetes mellitus has grown exponentially in the last few years. Etiopathogenesis of diabetes implies a ?-cells damage in the islet of Langerhans, either through an autoimmune reaction present in type 1 diabetic patients or through altered function within these cells that affect their ability to secrete a properly functioning insulin hormone, in patients suffering from type 2 diabetes. Exogenous insulin supply is, at the moment, the therapy of choice of the disease but it does not allow tight control of glucose regulation, leading to long-term complications. Over the past few decades, pancreas or pancreas-kidney organ transplantation has been the most effective treatment fo…
Nitric oxide metabolism is impaired by type 1 diabetes and diabetic nephropathy
2020
Diabetes leads to reduced nitric oxide bioavailability, resulting in endothelial dysfunction. However, overproduction of nitric oxide due to hyperglycaemia is associated with oxidative stress and tissue damage. The objective of this study was to characterise nitric oxide production (NO) and added nitrite and nitrate (NO(2)(-)+NO(3)(-)) concentration in the blood and urine of patients with and without diabetic nephropathy. A total of 268 patients with type 1 diabetes and 69 healthy subjects were included. Diabetic nephropathy was defined as macroalbuminuria and/or estimated glomerular filtration rate below 60 ml/min/1.73 cm(2). NO(2)(-)+NO(3)(-) concentration was measured by Griess reaction.…
Retinal Microcirculation in Type 1 Diabetic Patients With and Without Peripheral Sensory Neuropathy
2014
In patients with diabetes mellitus (DM), early retinal microvascular alterations can be observed even before the clinical diagnosis of diabetic retinopathy. This study aimed to investigate morphological and functional changes in retinal microvascular blood flow in type 1 diabetic patients with and without peripheral neuropathy (PNP) as compared to nondiabetic controls. Retinal microvascular blood flow (RBF) was assessed using scanning laser Doppler flowmetry (Heidelberg Retina Flowmeter, Heidelberg Engineering, Germany) before and after stimulation with flicker light. PNP was assessed using the neuropathy disability score (NDS) and by the evaluation of the vibration perception threshold (V…
Differences and Similarities in Neuropathy in Type 1 and 2 Diabetes: A Systematic Review
2021
Background: Diabetic neuropathy is defined as the dysfunction of the peripheral nervous system in diabetic patients. It is considered a microvascular complication of diabetes mellitus. Its presence is associated with increased morbidity and mortality. Although several studies have found alterations at somatic motor, sensory levels and at the level of autonomic nervous system in diabetic patients, there is not a systematic approach regarding the differences in neuropathy between the major variants of diabetes, e.g., type 1 and 2 diabetes at both neurological and molecular level. Data sources: we systematically (Medline, Scopus, and Cochrane databases) evaluated the literature related to the …
Chlamydia trachomatis Infection and Anti-Hsp60 Immunity: The Two Sides of the Coin
2009
Chlamydia trachomatis (CT) infection is one of the most common causes of reproductive tract diseases and infertility. CT-Hsp60 is synthesized during infection and is released in the bloodstream. As a consequence, immune cells will produce anti-CT-Hsp60 antibodies. Hsp60, a ubiquitous and evolutionarily conserved chaperonin, is normally sequestered inside the cell, particularly into mitochondria. However, upon cell stress, as well as during carcinogenesis, the chaperonin becomes exposed on the cell surface (sf-Hsp60) and/or is secreted from cells into the extracellular space and circulation. Reports in the literature on circulating Hsp and anti-Hsp antibodies are in many cases short on detai…
Adolescents with poorly controlled type 1 diabetes : psychological flexibility is associated with the glycemic control, quality of life and depressiv…
2021
This study investigates the role of psychological flexibility in relation to glycaemic control (HbA1c) and quality of life among adolescents with poorly-controlled diabetes. Adolescents (n = 65, aged 12–16 years) completed the Children and Adolescents Mindfulness Measure (CAMM), the Diabetes Acceptance and Action Scale for Children and Adolescents (DAAS), the Depression Scale (RBDI), and the Health-Related Quality of Life Scale (KINDL-R). HbA1c values were collected from medical records. A higher level of psychological flexibility was associated with better glycaemic control, better quality of life, and lower levels of depressive and anxiety symptoms. Mediation analysis showed that diabetes…
Effect of a HIIT protocol on the lower limb muscle power, ankle dorsiflexion and dynamic balance in a sedentary type 1 diabetes mellitus population: …
2020
Background Type 1 diabetes mellitus (T1DM) is commonly associated with premature loss of muscle function, ankle dorsiflexion and dynamic balance. Those impairments, usually, lead to physical functionality deterioration. High-intensity interval training is an efficient and safety methodology since it prevents hypoglycemia and not requires much time, which are the main barriers for this population to practice exercise and increase physical conditioning. We hypothesized that a 6-week HIIT program performed on a cycle ergometer would increase lower limb muscle power, ankle dorsiflexion range of motion and dynamic balance without hypoglycemic situations. Methods A total of 19 diagnosed T1DM sub…