Search results for "Type 2"
showing 4 items of 1034 documents
INFLUENCE OF FAMILY HISTORY OF TYPE 2 DIABETES ON PHENOTYPE AND PERFORMANCE IN YOUNG PEOPLE OF BOTH SEX.
2010
The type 2 diabetes is commonly considered a complex genetic disease, resulting from interactions between multiple genes and environmental factors without any single factor having strong independent effects. We studied the influence of family history to type 2 diabetes on physical phenotype of 47 health adolescents. In both sexes groups with positive family history (FH+) had the highest values of stature and body weight (p<0.05 for males, not significant for females), waist circumference (p<0.05 for males, not significant for females), and wrist circumference (p=0.05 for males, not significant for females). Considering performance, FH+ males showed a significant higher performance in power …
Family history to type 2 diabetes influence on body parameters of young soccer players
2011
The aim of our study was to analyze the difference of phenotype in healthy soccer players with family history of type 2 diabetes and healthy soccer players without family history of type 2 diabetes. The anthropometric parameters and body composition was analysed. The group with positive family history (FH+) had the highest values of wrist circumference (p<0.05) associated with not statistically significant increase of body fat mass and fat free mass. Also, the heart function was analysed. FH+ players had a diastolic basal pressure values higher than other group, but other functional parameters were the same. Analysing lung function indicators, FH+ players showed significant greater FEV1 and…
Perceived need to increase physical activity levels among adults at high risk of type 2 diabetes. A cross-sectional analysis within a community-based…
2012
Background. Increased physical activity is a cornerstone of type 2 diabetes prevention. The perception of a need to change is considered essential in behaviour change processes. However, the existing literature on individuals' perceived need to change health behaviour is limited. In order to improve understanding of diabetes prevention through increased physical activity levels (PAL), we assessed factors associated with perceiving a need to increase PAL among adults at high risk of diabetes. Methods. Opportunistic screening was used within a primary-care based lifestyle intervention covering 10 149 men and women at high risk of type 2 diabetes. Data were obtained at baseline visits. Th…
Impact of VP1-Specific Protein Sequence Motifs on Adeno-Associated Virus Type 2 Intracellular Trafficking and Nuclear Entry
2012
ABSTRACT Adeno-associated virus type 2 (AAV2) has gained much interest as a gene delivery vector. A hallmark of AAV2-mediated gene transfer is an intracellular conformational change of the virus capsid, leading to the exposure of infection-relevant protein domains. These protein domains, which are located on the N-terminal portion of the structural proteins VP1 and VP2, include a catalytic phospholipase A 2 domain and three clusters of basic amino acids. We have identified additional protein sequence motifs located on the VP1/2 N terminus that also proved to be obligatory for virus infectivity. These motifs include signals that are known to be involved in protein interaction, endosomal sort…