Search results for "Type A"

Epigenetic involvement in Hutchinson-Gilford progeria syndrome: a mini-review.

2013

Hutchinson-Gilford progeria syndrome (HGPS) is a rare human genetic disease that leads to a severe premature ageing phenotype, caused by mutations in the <i>LMNA</i> gene. The <i>LMNA</i> gene codes for lamin-A and lamin-C proteins, which are structural components of the nuclear lamina. HGPS is usually caused by a de novo <i>C1824T</i> mutation that leads to the accumulation of a dominant negative form of lamin-A called progerin. Progerin also accumulates physiologically in normal ageing cells as a rare splicing form of lamin-A transcripts. From this perspective, HGPS cells seem to be good candidates for the study of the physiological mechanisms of ageing…

Sp1 transcription factor interaction with accumulated prelamin a impairs adipose lineage differentiation in human mesenchymal stem cells: essential r…

2012

Abstract Lamin A (LMNA)-linked lipodystrophies may be either genetic (associated with LMNA mutations) or acquired (associated with the use of human immunodeficiency virus protease inhibitors [PIs]), and in both cases they share clinical features such as anomalous distribution of body fat or generalized loss of adipose tissue, metabolic alterations, and early cardiovascular complications. Both LMNA-linked lipodystrophies are characterized by the accumulation of the lamin A precursor prelamin A. The pathological mechanism by which prelamin A accumulation induces the lipodystrophy associated phenotypes remains unclear. Since the affected tissues in these disorders are of mesenchymal origin, we…

Semigenerated Carnot algebras and applications to sub-Riemannian perimeter

2021

This paper contributes to the study of sets of finite intrinsic perimeter in Carnot groups. Our intent is to characterize in which groups the only sets with constant intrinsic normal are the vertical half-spaces. Our viewpoint is algebraic: such a phenomenon happens if and only if the semigroup generated by each horizontal half-space is a vertical half-space. We call semigenerated those Carnot groups with this property. For Carnot groups of nilpotency step 3 we provide a complete characterization of semigeneration in terms of whether such groups do not have any Engel-type quotients. Engel-type groups, which are introduced here, are the minimal (in terms of quotients) counterexamples. In add…

Personality types in individuals with type 1 and type 2 diabetes

2020

Objective The Type A personality, characterized by impatience, strong career ambition and competitiveness, is associated with greater sensitivity to external stress. Type 1 diabetes (T1D) is an auto-immune disease, which is potentially influenced by stress, unlike type 2 diabetes (T2D). The aim of this study was to assess whether individuals with T1D and T2D exhibited significant differences on the Type A personality scale. We also assessed personality in patients with thyroid auto-immune diseases to validate potential links between auto-immune disease and Type A personality. Design and methods The Bortner questionnaire was used to assess Type A personality in 188 patients with T1D, 430 pa…

Different sample treatment approaches for the analysis of T-2 and HT-2 toxins from oats-based media.

2010

A LC-DAD method is proposed for the determination of the T-2 and HT-2 toxins in cultures of Fusarium langsethiae in oat-based and other in vitro media. Test media consisted of freshly prepared milled oats to which T-2 and HT-2 toxin stock solutions were added. Different mixtures of extraction solvent (acetonitrile:water and methanol water), extraction times (30', 60' or 90') and drying methods were investigated. Results showed that extraction with methanol: water (80:20, v/v) for 90 min, drying with N-2 and subsequent analysis by LC-DAD was the fastest and most user friendly method for detecting HT-2 and T-2 toxins production by F. langsethiae strains grown on oat-based media at levels of 0…

The semantics of complex demonstratives: a defense of character theories

2021

Aquesta tesi defensa una aproximació tradicional a la semàntica de demostratius complexos, ço és, expressions com "aquesta taula" o "aquell home". A la teoria clàssica, els demostratius complexos funcionen com qualsevol altre díctic: tal com ocorre amb paraules com ara "jo", "ella" o "ací", es tracta termes que depenen del context i que estan dotats d'un significat descriptiu anomenat "caràcter" que ajuda a fixar-ne referent en cada situació d’ús però que no juga cap més rol una vegada aquest individu ha estat determinat. El seu contingut o contribució proposicional és, al seu torn, un simple objecte. Aquest model dels demostratius complexos es troba justificat en la mesura que les expressi…

A web-based collection of genotype-phenotype associations in hereditary recurrent fevers from the Eurofever registry

2017

PubMed ID: 29047407

Successful treatment of axillary hyperhidrosis with very low doses of botulinum toxin B: a pilot study

2003

Complications of botulinum toxin and fillers: A narrative review

2019

Background Cosmetic surgery and esthetic procedures have become a billion dollar industry owing to the ever-growing demand of the population to stay young. The injectable treatments including fillers and botulinum toxin have become highly popular because of their quick, predictable and lasting results in the management of facial wrinkles and rejuvenation. Although these treatment modalities are relatively safe, they are associated with certain side effects. Aims In this review, we will focus on the complications of fillers and botulinum toxin. Patients/methods The literature research considered published journal articles (clinical trials or scientific reviews). Studies were identified by se…

Complications of Botulinum toxin A: An update review.

2021

Cosmetic surgery procedures have increased manifolds all over the world owing to the ever-increasing demand of people to look beautiful and young. Injectable treatments like botulinum toxin are becoming more popular owing to their rapid, well-defined, and lasting results for the reduction of facial fine lines, wrinkles, and facial rejuvenation. These emerging treatments are quite safe but can have certain adverse effects. In this article, we have highlighted the complications and side effects of botulinum toxin based on the anatomical location. The possible causes and precautions to prevent these complications are also discussed. The search of literature included peer-reviewed articles incl…