Search results for "Type A"

Visual field defects,type A personality,anxiety and coping styles in patients with primary open angle Glaucoma

2012

Functional characterisation of the first HSP110 inhibitors.

2023

Heat shock proteins are molecular chaperones highly expressed in haematological malignancies. My laboratory has shown that the heat shock protein HSP110 is a new and important therapeutic target In colorectal cancer and in non-Hodgkin's lymphoma. As there were no existing inhibitors of HSP110, a screening strategy of a chemical library was carried out and allowed the identification of two molecules capable of specifically inhibiting the chaperone activity of HSP110. My thesis objective was to characterise and functionally validate these newly identified molecules in diffuse large cell B lymphomas. I have shown that one of these molecules limits the interaction of HSP110 with the SYK signall…

Association between Satisfaction with Life and Personality Types A and D in Young Women with Acne Vulgaris

2020

People with acne vulgaris report a lower level of satisfaction with life and are more frequently classified as having Type D personalities than those without acne. This research examined, for the first time, the moderating and mediating role of personality type in the relationship between acne severity and satisfaction with life. Among 300 female nursing and cosmetology students ranging in age from 19 to 24 years (M = 21.28, SD= 1.39), 150 individuals (50%) presented with symptoms of acne vulgaris (AV group), while the other 150 (50%) were categorized as controls without acne vulgaris (WAV sample). A cross-sectional study was conducted using three self-report questionnaires: The Satisfactio…

The Language and Stereotype of Italians in Irish Culture

2009

This book examines the language of stereotyping produced by Irish journalists of The Irish Times and by Irish writers in their description, creation and interpretation of Italians living in Ireland and in Italy. The so-called Celtic Tiger phenomenon of economic boom has modified the images of Italians in Ireland, contributing to a shift from stereotypes to the so-called imagotypes. While in Ireland Italians have recently been “replaced” by such ethnic identities like Poles and Nigerians, and have consequently become more silent, in their home country they still retain those traits which can be defined truly stereotypical and which are especially perpetuated by the press. Detecting the prese…

A theoretical study of carbon-carbon bond formation by a Michael-type addition.

2012

A theoretical study of the Michael-type addition of 1,3-dicarbonyl compounds to α,β-unsaturated carbonyl compounds has been performed in the gas phase by means of the AM1 semiempirical method and by density functional theory (DFT) calculations within the B3LYP and M06-2X hybrid functionals. A molecular model has been selected to mimic the role of a base, which is traditionally used as a catalyst in Michael reactions, an acetate moiety to modulate its basicity, and point charges to imitate the stabilization of the negative charge developed in the substrate during the reaction when taking place in enzymatic environments. Results of the study of six different reactions obtained at the three di…

Visual Field defects, type A personality,anxiety and coping style in patients with primary open angle glaucoma.

2012

Classification of glaucomatous visual field defects for different severity levels is important. The reasons for this are numerous, and include: to distinguish between healthy and diseased individuals, to have homogeneous grouping criteria when perimetry is used to define the severity of glaucoma, to adjust therapy on the basis of disease severity, to describe visual field conditions in a short and simple format, to monitor the progression of the disease, and to provide a common language for both clinical and research purposes. Many severity classification methods have been proposed, although none have had widespread use in clinical practice. Other methods, like the cumulative defect curve (…

Convergence and applications of vector rational approximations

1992

The Padé approximants and their generalizations are for many years the matter of intense researchs .Yet , many theoritical problems stay in suspense : problems of exitence and unicity , problems of convergence and acceleration of convergence .The purpose of the present work vas to give answers to such questions .In the first section we take an in terest in vector Padé approximants of matrix series .Conditions of existence and unicity ,results of convergence are given ,as also the link with the theory of Lanczos method for the resolution of linear Systems . We utilize also the vector Padé approximants to provide a simultaneous approximation of a function and its derivative .In the second sec…

Population genetics on Ambrosia genus: past, present and future

2014

National audience; A new Task Force within the COST-SMARTER has recently been created. This group is composed of population genetics experts from five European countries in charge of focusing on “Genetics on Ambrosia” (Austria, France, Germany, Hungary, Sweden). Their mission was to review molecular methods used in published genetics studies on common ragweed and to discuss about future projects. Two different types of molecular markers are generally used in the literature to investigate the genetic structure within and between introduced and/or native populations of common ragweed: microsatellite markers and amplified fragment length polymorphism (AFLP). These methods permit the researcher…

Aplotype analysis in four sicilian families with 5083del19bp-BRCA1.

2007

Pluripotent stem cells to model Hutchinson-Gilford progeria syndrome (HGPS): Current trends and future perspectives for drug discovery

2015

Progeria, or Hutchinson-Gilford progeria syndrome (HGPS), is a rare, fatal genetic disease characterized by an appearance of accelerated aging in children. This syndrome is typically caused by mutations in codon 608 (p.G608G) of the LMNA, leading to the production of a mutated form of lamin A precursor called progerin. In HGPS, progerin accumulates in cells causing progressive molecular defects, including nuclear shape abnormalities, chromatin disorganization, damage to DNA and delays in cell proliferation. Here we report how, over the past five years, pluripotent stem cells have provided new insights into the study of HGPS and opened new original therapeutic perspectives to treat the disea…