Search results for "UK"
showing 10 items of 16131 documents
An Interactive Framework for Offline Data-Driven Multiobjective Optimization
2020
We propose a framework for solving offline data-driven multiobjective optimization problems in an interactive manner. No new data becomes available when solving offline problems. We fit surrogate models to the data to enable optimization, which introduces uncertainty. The framework incorporates preference information from a decision maker in two aspects to direct the solution process. Firstly, the decision maker can guide the optimization by providing preferences for objectives. Secondly, the framework features a novel technique for the decision maker to also express preferences related to maximum acceptable uncertainty in the solutions as preferred ranges of uncertainty. In this way, the d…
Tutkimusta lasten kanssa
2023
Artikkelissa tarkastellaan lasten ja tutkijoiden välisiä sukupolvisuhteita tutkimustoiminnassa. Tutkimusmenetelmänä ja tutkijoihin kohdistuvana pedagogisena menetelmänä käytetään kollaboratiivista autoetnografiaa. Artikkelissa hyödynnetään Pierre Bourdieun episteemisen refleksiivisyyden ajatusta eli tutkijan ja tutkittavien suhteiden ja asemien kriittistä arviointia. Lisäksi tutkimustoiminnassa toteutuvia sukupolvisuhteita tarkastellaan eksistentiaalisen, episteemisen ja juridis-eettisen ulottuvuuden avulla. Tutkimusaineisto koostuu tutkijoiden kirjoittamista autoetnografisista teksteistä sekä lapsille suunnattujen työpajojen litteraateista. Analyysi osoittaa, miten tärkeää on hahmottaa las…
Adult-onset Still's disease: an Italian multicentre retrospective observational study of manifestations and treatments in 245 patients
2016
Adult-onset Still’s disease (AOSD) is a systemic inflammatory condition of unknown aetiology characterized by typical episodes of spiking fever, evanescent rash, arthralgia, leukocytosis and hyperferritinemia. Given the lack of data in Italian series, we promote a multicentric data collection to characterize the clinical phenotype of Italian patients with AOSD. Data from 245 subjects diagnosed with AOSD were collected by 15 centres between March and May 2013. The diagnosis was made following Yamaguchi’s criteria. Data regarding clinical manifestations, laboratory features, disease course and treatments were reported and compared with those presented in other published series of different et…
Global translational repression induced by iron deficiency in yeast depends on the Gcn2/eIF2α pathway
2020
Iron is an essential element for all eukaryotic organisms because it participates as a redox active cofactor in a wide range of biological processes, including protein synthesis. Translation is probably the most energy consuming process in cells. Therefore, one of the initial responses of eukaryotic cells to stress or nutrient limitation is the arrest of mRNA translation. In first instance, the budding yeast Saccharomyces cerevisiae responds to iron deficiency by activating iron acquisition and remodeling cellular metabolism in order to prioritize essential over non-essential iron-dependent processes. We have determined that, despite a global decrease in transcription, mRNA translation is a…
Towards a Wellbeing-driven System Design for Intergenerational Collaborative Innovation: A Literature Review
2020
Researchers have previously utilized the advantages of a design driven by well-being and intergenerational collaboration (IGC) for successful innovation. Unfortunately, scant information exists regarding barrier dimensions and correlated design solutions in the information systems (IS) domain, which can serve as a starting point for a design oriented toward well-being in an IGC system. Therefore, in this study, we applied the positive computing approach to guide our analysis in a systematic literature review and developed a framework oriented toward well-being for a system with a multi-generational team. Our study contributes to the IS community by providing five dimensions of barriers to I…
AN IL-6/IL-6 SOLUBLE RECEPTOR (IL-6R) HYBRID PROTEIN (H-IL-6) INDUCES EPO-INDEPENDENT ERYTHROID DIFFERENTIATION IN HUMAN CD34+CELLS
2000
H-IL-6 is a hybrid protein constructed to contain IL-6 and its soluble receptor linked by a flexible peptide chain. Here we show that H-IL-6 strongly enhances proliferation of human CD34(+)cells in serum-free liquid culture, and that the majority of the cells generated belong to the erythroid lineage, being positive for the marker Glycophorin A. Conversely, H-IL-6 does not increase the number of myeloid, CD13-positive cells. Comparable effects are observed on progenitors from cord blood and adult peripheral blood. Therefore, H-IL-6 triggers an erythroid-inducing signal in haematopoietic progenitor cells, independently from erythropoietin (EPO).
Vuorovaikutuksen jännitteet toimittajan työssä: Sovittelujournalismin herättämiä näkökulmia
2018
Vuorovaikutus on läsnä toimittajien työssä monella tavalla. Suhde yleisöön on keskeinen toimittajan työtä määrittävä motivaatio ja työn kohde, ja suuri osa tiedonhankinnasta tapahtuu vuorovaikutuksessa lähteiden kanssa. Lisäksi toimitustyötä tehdään yhä enemmän erilaisissa ammatillisissa tiimeissä ja verkostoissa. Vaikka toimittajan työtä ja itseymmärrystä on tutkittu monesta näkökulmasta, vuorovaikutuksen tarkastelu on jäänyt vähäiseksi. Tässä artikkelissa analysoidaan, miten toimittajat kuvaavat työhönsä kuuluvaa vuorovaikutusta ja siihen sisältyviä jännitteitä. Tutkimusaineistona on Sovittelujournalismi-toimintatutkimushankkeen viidessä työpajaryhmässä eli yhteensä 14 työpajatapaamisessa…
IL-10 down-regulates T cell activation by antigen-presenting liver sinusoidal endothelial cells through decreased antigen uptake via the mannose rece…
1998
SUMMARYOur study demonstrates that antigen-presenting liver sinusoidal endothelial cells (LSEC) induce production of interferon-gamma (IFN-γ) from cloned Th1 CD4+ T cells. We show that LSEC used the mannose receptor for antigen uptake, which further strengthened the role of LSEC as antigen-presenting cell (APC) population in the liver. The ability of LSEC to activate cloned CD4+ T cells antigen-specifically was down-regulated by exogenous prostaglandin E2 (PGE2) and by IL-10. We identify two separate mechanisms by which IL-10 down-regulated T cell activation through LSEC. IL-10 decreased the constitutive surface expression of MHC class II as well as of the accessory molecules CD80 and CD86 …
In Vitro Cytokine Production by HLA-B8, DR3 Positive Subjects
1994
It is well known that healthy subjects carrying the HLA-B8,DR3 haplotype may show an impairment of immune system, the T cells being the most affected. To gain insight into the mechanism(s) of the impairment displayed by these subjects, efforts have been centered on the study of in vitro cytokine production because of the pivotal role played by these mediators in the activation and control of several immune functions. The available results indicate that the ability to several immune functions. The available results indicate that the ability to produce interleukin-1 (IL-1), IL-2 and the soluble form of its receptor (sIL-2R) is impaired in HLA-B8,DR3 positive healthy subjects. To better charac…
Fasciola spp: Mapping of the MF6 epitope and antigenic analysis of the MF6p/HDM family of heme-binding proteins
2017
MF6p/FhHDM-1 is a small cationic heme-binding protein which is recognized by the monoclonal antibody (mAb) MF6, and abundantly present in parenchymal cells and secreted antigens of Fasciola hepatica. Orthologs of this protein (MF6p/HDMs) also exist in other causal agents of important foodborne trematodiasis, such as Clonorchis sinensis, Opisthorchis viverrini and Paragonimus westermani. Considering that MF6p/FhHDM-1 is relevant for heme homeostasis in Fasciola and was reported to have immunomodulatory properties, this protein is expected to be a useful target for vaccination. Thus, in this study we mapped the epitope recognized by mAb MF6 and evaluated its antigenicity in sheep. The sequenc…