Search results for "UNAT"
showing 10 items of 112 documents
Cancer combination therapy of the sesquiterpenoid artesunate and the selective EGFR-tyrosine kinase inhibitor erlotinib.
2017
Abstract Background The shift from cytotoxic to targeted chemotherapy led to improved treatment outcomes in oncology. Nevertheless, many cancer patients cannot be cured from their disease because of the development of drug resistance and side effects. Purpose There is an ongoing quest for novel compounds, which raised not only the interest in natural products but also in novel combination therapy regimens. Study design In this review, we report on the inhibition epidermal growth factor receptor (EGFR) by targeted small molecules and their combination with natural products from medicinal plants. Results The combination of erlotinib with artesunate leads to synergistic inhibition of cell grow…
I10 The anticancer activity of the antimalarial artesunate
2017
More than a decade ago, we initiated a research program on the molecular pharmacology of phytochemicals derived from Chinese medicinal herbs. A promising compound was artemisinin from Artemisia annua L. and its semisynthetic compound artesunate [1] . Artemisinin and artesunate are anti-malarial drugs. Our data indicated profound activity against cancer cells, but also against various viruses, Schistosoma, Trypanosoma, and even plant crown gall tumors. To elucidate the molecular mode of actions against cancer, we applied molecular biological and pharmacogenomic approaches in vitro and in vivo. Different signalling pathways were identified not only in cancer cells but also in cells infected w…
The activity of Artemisia spp. and their constituents against Trypanosomiasis.
2018
Abstract Background Trypanosomiasis belongs to the neglected tropical diseases. Although standard therapies are available, the safety and efficacy of current synthetic drugs are limited due to the development of drug resistance and adverse side effects. Purpose Artemisia annua and artemisinin are not only active against Plasmodia, but also other protozoa. Therefore, we reviewed the literature on species of the genus Artemisia and their phytochemicals regarding their activity against trypanosomes. Study design A PubMed search for “Artemisia/Artemisinin and Trypanosoma” has been conducted for literature until December 2017. Results Interestingly, not only A. annua L. and its active principle,…
Artesunate Impairs Growth in Cisplatin-Resistant Bladder Cancer Cells by Cell Cycle Arrest, Apoptosis and Autophagy Induction
2020
Cisplatin, which induces DNA damage, is standard chemotherapy for advanced bladder cancer (BCa). However, efficacy is limited due to resistance development. Since artesunate (ART), a derivative of artemisinin originating from Traditional Chinese Medicine, has been shown to exhibit anti-tumor activity, and to inhibit DNA damage repair, the impact of artesunate on cisplatin-resistant BCa was evaluated. Cisplatin-sensitive (parental) and cisplatin-resistant BCa cells, RT4, RT112, T24, and TCCSup, were treated with ART (1&ndash
Expanding the Therapeutic Spectrum of Artemisinin: Activity Against Infectious Diseases Beyond Malaria and Novel Pharmaceutical Developments
2016
The interest of Western medicine in Traditional Chinese Medicine (TCM) as a source of drug leads/new drugs to treat diseases without available efficient therapies has been dramatically augmented in the last decades by the extensive work and the outstanding findings achieved within this kind of medicine. The practice of TCM over thousands of years has equipped scientists with substantial experience with hundreds of plants that led to the discovery of artemisinin (qinghaosu), which is extracted from the medicinal plant Artemisia annua L. (qinghao). The unexpected success of artemisinin in combating malaria has drawn strong attention from the scientific community towards TCM. Artemisinin was d…
Cardiotoxicity and Cardioprotection by Artesunate in Larval Zebrafish
2019
Although artesunate (ART) is generally accepted as a safe and well-tolerated first-line treatment of severe malaria, cases of severe side effects and toxicity of this compound are also documented. This study applied larval zebrafishes to determine the acute toxicity and efficacy of ART and performed RNA-sequencing analyses to unravel the underlying signaling pathways contributing to ART’s activities. Results from acute toxicity assay showed that a single-dose intravenous injection of ART from 3.6 ng/fish (1/9 maximum nonlethal concentration) to 41.8 ng/fish (lethal dose 10%) obviously induced pericardial edema, circulation defects, yolk sac absorption delay, renal edema, and swim bladder l…
Beyond malaria: The inhibition of viruses by artemisinin-type compounds
2018
Abstract Natural products represent valuable chemical scaffolds for drug development. A recent success story in this context was artemisinin, which is not only active against malaria but also to other diseases. This raised the interest of artemisinin's potential for drug repurposing. On the present review, we give an overview on artemisinin's antiviral activity. There is good in vitro and in vivo evidence for the activity of artemisinin and its derivatives against DNA viruses of the Herpesviridae and Hepadnaviridae families such as cytomegaloviruses, human herpesvirus 6, herpes simplex viruses 1 and 2, Epstein-Barr virus and Hepatitis B virus. The evidence is weaker for Polyomaviruses and p…
Arthroscopic Reinsertion of Acute Injuries of the Scapholunate Ligament Technique and Results
2020
Abstract Objective To describe a technique for treating acute injuries of the scapholunate ligament (SLL) by performing an arthroscopic reinsertion of the SLL and dorsal capsulodesis and to present the results obtained. Methods The study deals with an analytical, prospective clinical study that included 19 consecutive patients with acute injury of the SLL. The range of joint motion, grip strength, pain according to the visual analog scale, functional outcomes according to the Mayo Wrist Score (MWS), and the QuickDASH Score were studied preoperatively and 6 and 12 months postoperatively. The complications and necessary reinterventions were recorded. Results Nineteen patients with acute injur…
Religious-Philosophical Articles, XXXIII
2022
Žurnāla “Reliģiski-filozofiski raksti” XXXIII laidiens veltīts Latvijas sabiedrības vērtību analīzei salīdzinošā perspektīvā. Ņemot vērā vērtību jēdziena daudzdimensionālo raksturu, vērtību apraksts, analīze un klasifikācija visos laikos ir izraisījusi diskusijas, strīdus un pat konfliktus. Ideja veidot speciālu žurnāla numuru nolūkā veicināt teorētisko un empīrisko zināšanu attīstību par vērtībām Latvijā, aicinot sociālo un humanitāro zinātņu pētniekus dalīties ar jaunākajiem pētījumiem un atziņām šajā jomā, dzima projekta “Vērtību maiņa nestabilos apstākļos: sabiedrības saliedētība un neoliberālais ētoss” īstenošanas laikā. Pētnieciskā projekta tiešais mērķis bija sniegt jaunu salīdzinošu…
Latvijas Aizsargu jaunatnes organizācija (1932-1940)
2017
Darba mērķis ir veikt pētījumu par jauniešu dalību Latvijas Aizsargu organizācijā sākot ar 1932.gadā izveidotajiem aizsargu sporta pulciņiem un beidzot ar Latvijas Aizsargu organizācijas likvidēšanu 1940. gadā. Kā darba uzdevumi tika izvirzīti: izpētīt Latvijas Aizsargu jaunatnes regulējošos dokumentus un salīdzināt ar atspoguļojumu presē; izpētīt jaunatnes funkcijas un lomu Latvijas Aizsargu organizācijā; novērtēt Latvijas Aizsargu jaunatnes organizācijas lomu starp citām jaunatnes organizācijām sadarbībā ar Latvijas Aizsargu organizāciju. Pētījumā atklāts, ka aizsargu jaunatne bija ievērojama jauniešu organizācija visas Latvijas mērogā un kļuva par svarīgiem aizsargu dzīves aspektiem. Aiz…