Search results for "UPSTREAM"
showing 10 items of 47 documents
Stage–Discharge Relationship for an Upstream Inclined Grid with Transversal Bars
2016
AbstractCheck dams with grids upgrading upstream are often used in mountain rivers, where intense sediment transport and steep slopes occur. In some cases, sloping grids are used in the construction of debris flow breakers. In this paper, the outflow process of an upstream-inclined grid with transversal bars is studied by using the dimensional analysis and the incomplete self-similarity theory. Next, the theoretical analysis shows that a power equation can be used for establishing the stage-discharge equation. The coefficient of the power equation depends on both the slope angle and the void ratio, whereas the exponent depends only on the slope angle. Finally, this deduced stage–discharge r…
Experimental study and numerical simulation of inclined rectangular weirs
2018
Inclined rectangular weirs, also named pivot weirs, are used both to adjust the upstream water level and to increase the flow capacity compared with that of normal rectangular weirs. However, the experimental studies available in the literature present contradictory conclusions for the inclined weir discharge capacity. In this paper, new experimental runs and numerical simulations were performed to investigate the effect of the rectangular weir inclination angle on the stage-discharge formula. The experiments were carried out using inclination angles ranging from 30° to 90°. Buckingham's theorem of dimensional analysis was used to obtain an equation for the flow magnification ratio (the dis…
Comprehensive translational control of tyrosine kinase expression by upstream open reading frames
2016
Post-transcriptional control has emerged as a major regulatory event in gene expression and often occurs at the level of translation initiation. Although overexpression or constitutive activation of tyrosine kinases (TKs) through gene amplification, translocation or mutation are well-characterized oncogenic events, current knowledge about translational mechanisms of TK activation is scarce. Here, we report the presence of translational cis-regulatory upstream open reading frames (uORFs) in the majority of transcript leader sequences of human TK mRNAs. Genetic ablation of uORF initiation codons in TK transcripts resulted in enhanced translation of the associated downstream main protein-codin…
Experimental observations of upstream overdeepening
2005
The issue of morphodynamic influence in meandering streams is investigated through a series of laboratory experiments on curved and straight flumes. Both qualitative and quantitative observations confirm the suitability of the recent theoretical developments (Zolezzi & Seminara 2001) that indicate the occurrence of two distinct regimes of morphodynamic influence, depending on the value of the width ratio of the channel β. The threshold value βR separating the upstream from the downstream influence regimes coincides with the resonant value discovered by Blondeaux & Seminara (1985). Indeed it is observed that upstream influence may occur only in relatively wide channels, while narrower stream…
Regulation of human inducible nitric oxide synthase expression by an upstream open reading frame.
2019
Abstract The human inducible nitric oxide synthase (iNOS) gene contains an upstream open reading frame (uORF) in its 5′-untranslated region (5′-UTR) implying a translational regulation of iNOS expression. Transfection experiments in human DLD-1 cells revealed that the uORF although translatable seems not to inhibit the translation start at the bona fide ATG. Our data clearly show that human iNOS translation is cap-dependent and that the 5′-UTR of the iNOS mRNA contains no internal ribosome entry site. Translation of the bona fide coding sequence is most likely mediated by a leaky scanning mechanism. The 5′-UTR is encoded by exon 1 and exon 2 of the iNOS gene with the uORF stop codon located…
Epigenetic Alterations Upstream and Downstream of p53 Signaling in Colorectal Carcinoma
2021
Simple Summary Colorectal cancer (CRC) belongs to the most common cancer types. It is well known that half of all CRC possess missense mutations in the TP53 tumor suppressor gene. However, the entire signaling cascade upstream and downstream of the p53 protein may also contribute to CRC development, if relevant players in this signaling cascade lost their function. Besides p53 loss-of-function by mutations, epigenetic changes (DNA methylation, post translational modifications of histones, micro-RNAs) play a vital role in CRC development. In the present review, we concentrated on the epigenetic modifications related to the entire p53 signal transduction cascade upstream and downstream of p53…
GAL4-responsive UAS- tau as a tool for studying the anatomy and development of the Drosophila central nervous system
1997
To improve the quality of cytoplasmic labelling of GAL4-expressing cells in Drosophila enhancer-trap and transgenic strains, a new GAL4-responsive reporter UAS-tau, which features a bovine tau cDNA under control of a yeast upstream activation sequence (UAS), was tested. Tau, a microtubule-associated protein, is distributed actively and evenly into all cellular processes. Monoclonal anti-bovine Tau antibody reveals the axonal structure of the labelled cells with detail similar to that of Golgi impregnation. We demonstrate that the UAS-tau system is especially useful for studying processes of differentiation and reorganisation of identified neurones during postembryonic development.
Numerical implementation of active power flow tracing methods: Practical implications on transmission networks and DR programs support
2015
The goal of this paper is to demonstrate the powerful contribution of the electric active power flow tracing methods on studying the electric transmission systems operating conditions. The tracing methods allow to impute to every generation unit and/or load the responsibility of the power flows of all the elements connected to the network. This study propose the numerical implementation of two different tracing methods on two transmission networks through Matlab® scripts developed on purpose; then the analysis is focused on identifying the loads which mostly affect the power line flows of the system. The results of this analysis point out the loads on which the application of the Demand Res…
Reciprocal regulation of the human sterol regulatory element binding protein (SREBP)-1a promoter by Sp1 and EGR-1 transcription factors.
2007
AbstractSterol regulatory element binding protein (SREBP)-1a is a transcription factor that is highly expressed in actively growing cells, and is involved in the biosynthesis of cholesterol, fatty acids and phospholipids. We have mapped the minimal human SREBP-1a promoter region to 75bp upstream of the translation start site where we discovered a functional role for the 3 GC-boxes containing overlapping sites for the Sp1 and EGR-1 transcription factors. Intact SP1-binding sites are essential for promoter activity, whereas EGR-1 suppresses the transcription of the human SREBP-1a promoter. These results reveal a novel physiologically relevant transcriptional mechanism for the reciprocal regul…
Assessment of data and parameter uncertainties in integrated water-quality model
2011
In integrated urban drainage water quality models, due to the fact that integrated approaches are basically a cascade of sub-models (simulating sewer system, wastewater treatment plant and receiving water body), uncertainty produced in one sub-model propagates to the following ones depending on the model structure, the estimation of parameters and the availability and uncertainty of measurements in the different parts of the system. Uncertainty basically propagates throughout a chain of models in which simulation output from upstream models is transferred to the downstream ones as input. The overall uncertainty can differ from the simple sum of uncertainties generated in each sub-model, dep…