Search results for "Uber"
showing 10 items of 1027 documents
The zebrafish embryo as an in vivo model for screening nanoparticle-formulated lipophilic anti-tuberculosis compounds.
2021
ABSTRACT With the increasing emergence of drug-resistant Mycobacterium tuberculosis strains, new and effective antibiotics against tuberculosis (TB) are urgently needed. However, the high frequency of poorly water-soluble compounds among hits in high-throughput drug screening campaigns is a major obstacle in drug discovery. Moreover, in vivo testing using conventional animal TB models, such as mice, is time consuming and costly, and represents a major bottleneck in lead compound discovery and development. Here, we report the use of the zebrafish embryo TB model for evaluating the in vivo toxicity and efficacy of five poorly water-soluble nitronaphthofuran derivatives, which were recently id…
Nanocarriers for respiratory diseases treatment: Recent advances and current challenges
2014
Pulmonary delivery of locally-acting drugs encapsulated in nanocarriers provides several advantages for the treatment of respiratory diseases such as asthma, chronic obstructive pulmonary diseases, cystic fibrosis, tuberculosis and lung cancer. These advantages include, among others, sustained drug delivery to the lungs, reduced therapeutic dose and improved patient compliance. The aim of this review is to give an updated overview on recent advances recorded in the last few years in this field as well as on the major challenges still existing and that remain to be overcome before any clinical application. After an outline on the cellular and extracellular barriers affecting drug delivery to…
Likkumi Widsemmes semneekeem dohti [Likumi Vidzemes zemniekiem doti]
1820
Bibliogrāfiskās ziņas: Seniespiedumi latviešu valodā, 1525-1855 : kopkatalogs. Rīga : Latvijas Nacionālā bibliotēka, 1999, Nr. 1041. Pieejams tiešsaistē: seniespiedumi_latviesu_valoda_1525_1855.pdf
Siliceous spicules in marine demosponges (example Suberites domuncula)
2005
All metazoan animals comprise a body plan of different complexity. Since-especially based on molecular and cell biological data-it is well established that all metazoan phyla, including the Porifera (sponges), evolved from a common ancestor the search for common, basic principles of pattern formation (body plan) in all phyla began. Common to all metazoan body plans is the formation of at least one axis that runs from the apical to the basal region; examples for this type of organization are the Porifera and the Cnidaria (diploblastic animals). It seems conceivable that the basis for the formation of the Bauplan in sponges is the construction of their skeleton by spicules. In Demospongiae (w…
Dialogues of Joy : Shared Moments of Joy Between Teachers and Children in Early Childhood Education Settings
2019
Abstract The study focuses on teachers’ and children’s shared moments of joy in early childhood education settings and contributes new knowledge in educational research by exploring joy as a relational rather than an individual phenomenon. The theoretical and methodological framework draws on a narrative approach and Martin Buber’s dialogical philosophy. Data were gathered through video observations and diary notes in open ECE groups in Finland, with children from 2 to 6 years. The scenes of everyday life in ECE appeared to radiate an overall positive atmosphere. However, the relationship between shared joy and dialogue was multifaceted. On one hand, joyful moments between teachers and chil…
A stochastic model of seed dispersal pattern to assess seed predation by ants in annual dry grasslands
2005
A combined field experiment and modelling approach has been used to provide evidence that ants may be responsible for an observed lower patchiness and higher plant diversity in the neighbourhood of ant nests, within Mediterranean dry grasslands belonging to the phytosociological class Tuberarietea guttatae. The hypothesis was that seeds occurring in clumps may have an higher probability to be harvested than seeds having a scattered distribution. In order to test this hypothesis, four analysis steps have been performed. First, the seed productivity and dispersal pattern was recorded for four plant species found, either more abundant beside the ant nests (Tuberaria guttata, Euphorbia exigua) …
The multixenobiotic resistance mechanism in the marine sponge Suberites domuncula: its potential applicability for the evaluation of environmental po…
1996
Experiments were carried out with the marine sponge Suberites domuncala to determine whether sponges may express - like mammalian tumor cells a multidrug-like transporter system. The results demonstrate that sponge cells possess such a protective system termed multixenobiotic resistance (MXR) pump or P-glycoprotein-like pump, The protein was identified by antisera for the mammalian P170 multidrug resistance protein as a 130 kDa molecule, Binding studies were performed with H-3-vincristine (H-3-VCR) and membrane vesicles ; this process is ATP-dependent and inhibited by verapamil, which is known to reverse the multidrug-resistance phenotype in mammalian systems, Accumulation experiments were …
Molecular response of the sponge Suberites domuncula to bacterial infection
2001
The aim of this study was the documentation of the molecular immune response of Suberites domuncula upon bacterial infection. Additionally, the bacteria that are naturally present in the sponge after prolonged aquarium maintenance were characterized. After 6 months of maintenance of S. domuncula in seawater aquaria, only one bacterial 16S rDNA sequence could be recovered, which belongs to the genus Pseudomonas. Concomitantly, morphologically uniform bacteria were found encapsulated in bacteriocytes. These findings indicate that certain bacteria, possibly of the genus Pseudomonas, are able to persist for long periods in host bacteriocytes. Subsequent to performing a previously established in…
Health sector spending and spending on HIV/AIDS, tuberculosis, and malaria, and development assistance for health: progress towards Sustainable Devel…
2020
BACKGROUND: Sustainable Development Goal (SDG) 3 aims to "ensure healthy lives and promote well-being for all at all ages". While a substantial effort has been made to quantify progress towards SDG3, less research has focused on tracking spending towards this goal. We used spending estimates to measure progress in financing the priority areas of SDG3, examine the association between outcomes and financing, and identify where resource gains are most needed to achieve the SDG3 indicators for which data are available. METHODS: We estimated domestic health spending, disaggregated by source (government, out-of-pocket, and prepaid private) from 1995 to 2017 for 195 countries and territories. For …
Saving Technologies that are not Used to Save Lives
2021
A hundred years ago in July, thanks to the advancement of medical technology, the first human received the vaccine Bacille Calmette-Guérin—or BCG—to prevent tuberculosis (TB), a disease that killed at least 20% of the European population during the 19th century. Since then, hundreds of millions of lives have been saved by BCG, as well as other vaccinations for dangerous diseases. However, although TB is quite preventable and curable, it remains the leading cause of death from a single infectious agent in the world. It is an example of how humans can invent technologies to improve and save lives but fail to do so because of unevenly distributed resources, lack of media coverage, and other ec…