Search results for "Ulcer"
showing 10 items of 523 documents
The lung in inflammatory bowel disease.
2000
Dzīves kvalitāte pacientiem ar iekaisīgo zarnu slimībām Latvijā
2017
Ievads: čūlains kolīts (ČK) un Krona slimība (KS) ir divas galvenās neizārstējamās iekaisīgu zarnu slimības (IZS), kuras bez slimībai specifiskajiem simptomiem būtiski ietekmē arī pacientu dzīves kvalitāti (DzK). Darba mērķi: Novērtēt pacientu ar IZS dzīves kvalitāti, korelāciju starp slimības gaitu un DzK, salīdzināt ČK un KS pacientu dzīves kvalitāti un noskaidrot, vai pastāv korelācija starp DzK un klīniskajiem un demogrāfiskiem rādītājiem. Materiāls un metodes: Tika atlasīti gan stacionēti, gan ambulatori pacienti, kuriem tika lūgts aizpildīt IZS anketu (IZSA), novērtējot sociālos, emocionālos u.c. aspektus, kā arī otru anketu ar vispārīgiem un demogrāfiskiem datiem. Rezultāti: Kopā pēt…
QSAR methods for the discovery of new inflammatory bowel disease drugs
2013
Inflammatory bowel disease (IBD) represents an important class of chronic gastrointestinal tract disease. And although there are already several useful treatments to reduce and control the symptoms, there is still no cure. One drug discovery technique used is the computer-aided (in silico) discovery approach which has largely demonstrated efficacy. Computational techniques, when used in combination with traditional drug discovery methodology, greatly increase the chance of drug discovery in a sustainable and economical fashion.This review aims to provide the most recent and important advances of in silico IBD drug discovery. While this review is mainly focused on QSAR methods, especially th…
The foot fillet flap for ischial pressure sore reconstruction: A new indication
2018
Abstract Introduction The main cause of ischial pressure sores in paraplegic patients is prolonged sitting without pressure relief. These wounds are subject to recurrence and may need repeated reconstruction with local flaps. When all options are exhausted, the total thigh flap is the last resort. Disarticulation of the hip joint impairs stability even when sitting and causes subsequently very high discomfort. In this manuscript, we describe an alternative to the total thigh flap to avoid hip disarticulation: the foot fillet flap. Materials & Methods This study was performed on four patients at the department of Plastic & Reconstructive Surgery of the Ghent University Hospital, Belgium. Inc…
Electrochemotherapy for advanced cutaneous angiosarcoma: A European register-based cohort study from the International Network for Sharing Practices …
2019
Abstract Background Cutaneous angiosarcoma (cAS) is a highly aggressive malignancy that challenges the radicality of surgical treatment. Electrochemotherapy (ECT), a skin-directed treatment based on cytotoxic chemotherapy combined with local electric pulses, may be an intraoperative adjunct and a new opportunity in the therapeutic strategy. This cohort study reports the experience with ECT as an option. Methods Data on patients with locally-advanced/metastatic cAS who underwent ECT between October 2013 and October 2018 at eight European centres were prospectively submitted to the InspECT (International network for sharing practices of ECT) register. Patients received therapy according to th…
Epidemiological trends of pediatric IBD in Italy: A 10-year analysis of the Italian society of pediatric gastroenterology, hepatology and nutrition r…
2022
Introduction: The present study aimed at evaluating Italian epidemiological trends of pediatric inflammatory bowel diseases (IBD) over the period 2009–2018. Materials and methods: Data from 1969 patients enrolled in the Italian Society of Pediatric Gastroenterology, Hepatology and Nutrition Registry, by 49 pediatric IBD centers throughout the country, were analyzed, comparing three different time intervals (2009–2012, 2013–2015, 2016–2018). Results: The number of new IBD diagnoses ranged from 175 to 219 per year, evenly distributed over the examined period of time. From 2009 to 2018, the minimal incidence ranged from 1.59 to 2.04 /105 inhabitants aged < 18 years, with an overall slight p…
Mortality rate and risk factors for gastrointestinal bleeding in elderly patients
2019
Abstract Background Gastrointestinal bleeding (GIB) is burdened by high mortality rate that increases with aging. Elderly patients may be exposed to multiple risk factors for GIB. We aimed at defining the impact of GIB in elderly patients. Methods Since 2008, samples of elderly patients (age ≥ 65 years) with multimorbidity admitted to 101 internal medicine wards across Italy have been prospectively enrolled and followed-up (REPOSI registry). Diagnoses of GIB, length of stay (LOS), mortality rate, and possible risk factors, including drugs, index of comorbidity (Cumulative Illness Rating Scale [CIRS]), polypharmacy, and chronic diseases were assessed. Adjusted multivariate logistic regressio…
Transanal total mesorectal excision for restorative coloproctectomy in an obese high-risk patient with colitis-associated carcinoma
2016
Transanal total mesorectal excision (TaTME) offers great potential for the treatment of malign and benign diseases. However, laparoscopic-assisted TaTME in ulcerative colitis has not been described in more than a handful of patients. We present a 47-year-old highly comorbid female patient with an ulcerative colitis-associated carcinoma of the ascending colon and steroid- refractory pancolitis. A two-stage restorative coloproctectomy including right-sided complete mesocolic excision was conducted. The second step consisted of a successful nerve-sparing TaTME and a handsewn ileal pouch-anal anastomosis. TaTME may extend the possible treatment options in inflammatory bowel disease, especially …
Is routine second-look endoscopy effective after endoscopic hemostasis in acute peptic ulcer bleeding? A meta-analysis
2012
Background Routine second-look endoscopy in modern-era peptic ulcer bleeding (PUB) remains controversial. Objective To assess the effectiveness of routine second-look endoscopy in patients with PUB exhibiting high-risk stigmata after standard medical care and endoscopic therapy. Design Comprehensive literature searches (1990-2011) were performed, seeking randomized trials comparing a routine with an as-needed second endoscopy. Main Outcome Measurements The main outcome was rebleeding. Secondary outcomes were surgery and mortality. Subanalyses assessed the influence of study quality, rebleeding definitions, endoscopic hemostasis modality, and proton pump inhibitor (PPI) therapies. Analyses w…
Estudio de la prevalencia de incontinencia fecal y alteración de la calidad de vida referida a la misma en pacientes con enfermedad inflamatoria inte…
2017
RESUMEN Objetivos: Conocer la prevalencia de la incontinencia fecal (IF) en los pacientes con Enfermedad Inflamatoria Intestinal Crónica (EIIC) y analizar su impacto en la calidad de vida. Métodos: Estudio prospectivo aleatorizado, descriptivo y analítico en 726 pacientes con EIIC (Enfermedad de Crohn (EC) y Colitis Ulcerosa (CU)) pertenecientes al departamento de salud del Hospital Clínico de Valencia. Se excluyen pacientes<18 años, pacientes con colitis indeterminadas, portadores de colostomías, ileostomías, reservorios o deterioro cognitivo. Se recogen variables demográficas, características fenotípicas de su EIIC, antecedentes personales y actividad de la EIIC. Se evalúa la calidad de v…