Search results for "Ull"
showing 10 items of 3152 documents
Granulocyte functions are independent of arginine availability.
2014
Abstract Arginine depletion via myeloid cell arginase is critically involved in suppression of the adaptive immune system during cancer or chronic inflammation. On the other hand, arginine depletion is being developed as a novel anti-tumor metabolic strategy to deprive arginine-auxotrophic cancer cells of this amino acid. In human immune cells, arginase is mainly expressed constitutively in PMNs. We therefore purified human primary PMNs from healthy donors and analyzed PMN function as the main innate effector cell and arginase producer in the context of arginine deficiency. We demonstrate that human PMN viability, activation-induced IL-8 synthesis, chemotaxis, phagocytosis, generation of RO…
Activation of nitric oxide signaling by the rheumatoid arthritis shared epitope
2006
Objective. Susceptibility to rheumatoid arthritis (RA) is closely associated with HLA–DRB1 alleles encoding a shared epitope (SE) in positions 70–74 of the HLA–DR chain. The mechanistic basis for this association is unknown. Given the proposed pathogenic role of nitric oxide (NO) in RA, this study was undertaken to examine whether the SE can trigger NO signaling events. Methods. The intracellular levels of NO were measured with the fluorescent NO probe 4,5diaminofluorescein diacetate and by the 2,3diaminonaphthalene method. NO synthase activity was determined by measuring the rate of conversion of radioactive arginine to citrulline. Levels of cGMP were measured with a commercial enzyme-link…
Gli studi sull’arte armena a Venezia. Alpago Novello e le prospettive di ricerca
2020
<div> <p>This paper aims to retrace the Armenian Studies’ tradition in Venice. This tradition moved from the firsts scientific publications edited by the Mechitarist Congregation of San Lazzaro to Ca’ Foscari University’s first chair of Armenian Studies, led by father Levon Zekyan in 1976. During that year, Adriano Alpago Novello founded the Study and Documentation Centre of Armenian Culture that in 1992 moved from Milan to Venice. The present paper focuses on the legacy of Alpago Novello through the analysis of his working methods and results in the context of the history of Armenian art and architecture. His methodology belongs to the field of the ecology of art.</p> <…
Amor odit inertes (Ars 2, 229): Mobilità didascalica e staticità elegiaca
2005
Un'analisi della precettistica contenuta in Ars 2, 223-250 sulla 'dinamicità' dell'innamorato, letta come voluto rovesciamento, dall'interno, delle categorie spaziali elegiache The precepts of Ars 2, 223-250 on the lover's 'dynamic' attitude are read as a conscious reversal, from within, of the elegiac spatial cathegories.
Pullneyocoris dentatus gen. et sp. nov. (Hemiptera: Pentatomoidea: Cydnidae), the third representative of the subfamily Amnestinae from mid-Cretaceou…
2020
Abstract A new genus and species of burrower bug, Pullneyocoris dentatus gen. et sp. nov. (Hemiptera: Cydnidae: Amnestinae), is described from amber of northern Myanmar. It is the third representative of this family known from Burmese amber, and besides its autapomorphies, it presents a mixture of characters relevant to the extant Parachilocoris Horvath, 1919 and Pullneya Horvath, 1919. A comparison of this new genus to the two genera already described from the burmite, i.e. Chilamnestocoris Lis J.A., Lis. B. & Heiss, 2018, and Punctacorona Wang, Du, Yao & Ren, 2019 is also provided.
A Fast Imaging Technique Applied to 2D Electrical Resistivity Data
2014
A new technique is proposed to process 2D apparent resistivity datasets, in order to obtain a fast and contrasted resistivity image, useful for a rapid data check in field or as a starting model to constrain the inversion procedure. In the past some modifications to the back-projection algorithm, as well as the use of filtering techniques for the sensitivity matrix were proposed. An implementation of this technique is proposed here, considering a two-step approach. Initially a damped least squares solution is obtained after a full matrix inversion of the linearized geoelectrical problem. Furthermore, on the basis of the results, a subsequent filtering algorithm is applied to the Jacobian ma…
Demand Sharing Inaccuracies in Supply Chains: A Simulation Study
2018
We investigate two main sources of information inaccuracies (i.e., errors and delays) in demand information sharing along the supply chain (SC). Firstly, we perform a systematic literature review on inaccuracy in demand information sharing and its impact on supply chain dynamics. Secondly, we model several SC settings using system dynamics and assess the impact of such information inaccuracies on SC performance. More specifically, we study the impact of four factors (i.e., demand error, demand delay, demand variability, and average lead times) using three SC dynamic performance indicators (i.e., bullwhip effect, inventory variability, and average inventory). The results suggest that demand …
Impact of a Social Constructivist Instructional Strategy on Performance in Algebra with a Focus on Secondary School Students
2020
There have been perennial concerns on the low academic performance of students among researchers and other education stakeholders. Innovative teaching strategies have, therefore, gained prominence in the field of mathematics education. The purpose of this study is to investigate the impact of a social constructivist instructional strategy on students’ performance in algebra. The present study is quasi-experimental, and its type is a posttest control group involving 154 secondary school students that are randomly selected across four intact classes. The random selection of students to treatment and control controls is assumed to improve the validity of the results. Two research questions are…
Comparison of approaches for generation of fully non-stationary artificial accelerograms
2019
The modelling of the seismic input is a critical aspect when non-linear time-history analyses (NLTHAs) are carried out. As a matter of fact, seismic response of structures is very sensitive to the input excitation time history. The present work aims to highlight the differences in the input modelling and the assessment of seismic response of three r.c. structures employing four generation methods of fully non-stationary artificial accelerogram sets at a given construction site. For each method, seven accelerograms are generated and employed to perform NLTHAs on three r.c. structures having irregular mass and stiffness distributions. The original contribution of the paper relies in the crite…
Comparison of the H-alpha circumstellar disks in Be/X-ray binaries and Be stars
2000
We present a comparative study of the circumstellar disks in Be/X-ray binaries and isolated Be stars based upon the H-alpha emission line. From this comparison it follows that the overall structure of the disks in the Be/X-ray binaries is similar to the disks of other Be stars, i.e. they are axisymmetric and rotationally supported. The factors for the line broadening (rotation and temperature) in the disks of the Be stars and the Be/X-ray binaries seem to be identical. However, we do detect some intriguing differences between the envelopes. On average, the circumstellar disks of the Be/X-ray binaries are twice as dense as the disks of the isolated Be stars. The different distribution of the…