Search results for "Umana"
showing 10 items of 657 documents
La adición de LH a la estimulación ovárica no produce más maduración endometrial prematura ni diferente patrón de expresión génica endometrial que la…
2015
El papel de la LH es controvertido en los tratamientos de reproducción asistida. La LH permitiría la eliminación del exceso de progesterona durante la fase folicular. La estimulación ovárica favorece la maduración endometrial prematura (MEP). Esta tesis evalua el impacto de la LH sobre la MEP y describe su análisis génico endometrial. Material y Métodos: Seis donantes de ovocitos se sometieron a dos procesos de estimulación cada una. Cinco días después de suspendidos los anticonceptivos se estimularon con 187,5 UI/d de FSHr (GonalF) o la misma dosis de FSH+LHr 75 UI/d. Para asegurar la ausencia de actividad LH endógena se añadió cetrorelix 0,25mg/d desde el primer día de estimulación ováric…
Estimulación ovárica y sus variantes y su efecto sobre la calidad embrionaria; análisis morfocinético mediante cinematografía
2012
El trabajo está basado en la influencia de los protocolos de estimulación ovárica sobre la cinética de división embrionaria. La herramienta que se ha utilizado para evaluar la cinética de división embrionaria ha sido el Embryoscope®, que es un incubador que consta de un sistema interno que permite la toma de imágenes de alta resolución en intervalos de tiempos predeterminados (en este caso cada veinte minutos). Este recurso técnico permite poder conocer con exactitud los distintos hitos en el desarrollo de los embriones, tales como los tiempos de división celular, cosa que con las observaciones con microscopía convencional no resulta posible y se pierde una fuente de datos que pueden ser fu…
La gobernanza como método para encarar los nuevos grandes retos territoriales y urbanos
2008
Joaquin.Farinos@uv.es
Wharton’s Jelly Mesenchymal Stem Cells as Candidates for Beta Cells Regeneration: Extending the Differentiative and Immunomodulatory Benefits of Adul…
2010
Mesenchymal stem cells (MSC) are uniquely capable of crossing germinative layers borders (i.e. are able to differentiate towards ectoderm-, mesoderm- and endoderm-derived cytotypes) and are viewed as promising cells for regenerative medicine approaches in several diseases. Type I diabetes therapy should potentially benefit from such differentiated cells: the search for alternatives to organ/islet transplantation strategies via stem cells differentiation is an ongoing task, significant goals having been achieved in most experimental settings (e.g. insulin production and euglycaemia restoration), though caution is still needed to ensure safe and durable effects in vivo. MSC are obtainable in …
Exosomal Hsp60 levels and related miRNA in brain tumor cells
2018
One of the many pathologic conditions still without a satisfactory solution is that of brain tumors. The prognosis is poor even after surgical resection followed by post-operatory chemo- and radio-therapie (1). It is, therefore, cogent to find innovative treatment tools. Three recent developments may provide elements to discover novel treatment strategies and means. These developments are: the discovery that molecular chaperones can be determinant factors in the process of tumorigenesis (2); the elucidation of the role of miRNAs in gene regulation and determination of protein functions, including molecular chaperones; in the various cell compartments (3);the increasing understanding and cha…
Jürgen Habermas and the risk of liberal eugenics for the ethical self-understanding of species
2016
El artículo analiza el problema de la naturaleza humana que presenta Jürgen Habermas en su obra El futuro de la naturaleza humana, ¿Hacia una eugenesia liberal? Los vertiginosos avances biotecnológicos reclaman una rigurosa reflexión bioética que el filósofo alemán afronta superponiendo a su ética del discurso una ética de la especie. Habermas esboza un modelo de naturaleza humana construido sobre preceptos como la dignidad humana y de la vida humana, la simetría de las relaciones intersubjetivas y, a resultas de estas, la autocomprensión ética de la especie. Respecto a la eugenesia liberal, el autor se posiciona criticando la eugenesia positiva y amparando la negativa, para lo que basa su …
Role of endothelial cell stress in the pathogenesis of chronic heart failure.
2009
Endothelial cells are key modulators of diverse physiological processes, and their impaired function is a cause of numerous cardiovascular diseases. Under physiologic condition, the reactive oxygen and nitrogen mediators in endothelia lead to the signal propagation of the initial stimulus, by forming molecules with a longer half-life like hydrogen peroxide. Hydrogen peroxide is the focus of growing attention in endothelial biology, and consequently the enzymes involved in its generation and clearance are viewed as novel mediators of great importance. In particular, among peroxidases, myeloperoxidase is recognized as a key enzyme, capable of impairing intracellular NO reservoirs as well as p…
Adult stem cells, scaffolds for in vivo and in vitro myocardial tissue engineering
2010
Recent Advances in Derivation of Functional Hepatocytes from Placental Stem Cells
2013
Abstract: End-stage liver diseases are one of the leading causes of death in the world. Often orthotopic liver transplantation represents the final therapeutic choice. The limits of this approach are the scarcity of donor livers available, and the many side effects related to the administration of immune suppressants to the patients. Cellular therapy for liver diseases is increasingly being viewed as a promising strategy to provide hepatocytes to replenish the parenchymal cells of the organ. This technique suffers of some important limitations, such as the difficulty in isolating sufficient cell numbers (e.g. when adult or foetal hepatocytes are used for transplantation), the limited viabil…
Human Wharton's jelly-derived mesenchymal stem cells express several immunomodulatory molecules both in their naïve state and hepatocyte-like differe…
2011
Wharton’s jelly (WJ), the main constituent of umbilical cord, is a reliable source of mesenchymal stem cells (MSC). WJ-MSC show unique ability in crossing lineage borders. As other extraembryonic mesenchymal populations (placenta and amnionderived cells), WJ-MSC express several immunomodulatory molecules, essential during the initial phases of human development. Indeed, our recent work pointed out the expression of non-classical HLA molecules as HLA-G in such cells, together with a favorable combination of B7 costimulators. Very few data in literature suggest that some of the immune features of the naïve cells are maintained after performing differentiation. The aim of this work was extendi…