Search results for "Umana"
showing 10 items of 657 documents
Ensenyant Horta, aprenent paisatge. Anàlisi dels discursos educatius sobre el paisatge de l'Horta i propostes de millora
2017
Al País Valencià existeixen espais agraris periurbans que conformen paisatges d'especial singularitat com ara l'Horta de València, que malgrat la seua importància està travessada per múltiples problemàtiques. Als centres d'educació secundària la majoria dels discursos sobre espai agrari que es transmeten des dels manuals escolars i el professorat s'hi apropen de manera taxonòmica, pobre i simplificadora, així com des d'un punt de vista únicament productivista, obviant tota la resta de dimensions des de les quals es pot analitzar un paisatge. Un ensenyament més convenient sobre els espais agraris a la comarca de l'Horta hauria d'estar íntimament lligat al medi local, així com contemplar tote…
536. Internal and international mobility of Romanian immigrants during the crisis
2016
Para paliar los efectos de la crisis económico-laboral, iniciada en 2007, los inmigrantes han desplegado diversas estrategias, entre las que destaca la movilidad geográfica. El artículo indaga en las migraciones que en los últimos años realizan los rumanos en España y desde España, para lo que se utilizan dos fuentes de información complementarias: la estadística y los testimonios de los inmigrantes. Los resultados de la investigación muestran el notable aumento de la circulación interior de trabajadores durante los primeros años y el progresivo aumento de las salidas, ya sea para retornar al lugar de origen, emigrar a otros países o desplazarse entre diferentes lugares. En general, estos d…
Suppressor of cytokine signaling 3 sensitizes anaplastic thyroid cancer to standard chemotherapy
2009
We previously showed that cancer cells from papillary, follicular, and anaplastic thyroid carcinomas produce interleukin-4 and interleukin-10, which counteract the cytotoxic activity of conventional chemotherapy through the up-regulation of antiapoptotic molecules. Here, we identify Janus kinase/signal transducers and activators of transcription (STAT) and phosphatidyl inositol 3-kinase (PI3K)/AKT as the down-stream pathways through which these cytokines confer resistance to cell death in thyroid cancer. We found that the absence of suppressors of cytokine signaling (SOCS) molecules allows the propagation of the survival signaling. Exogenous expression of SOCS1, SOCS3, and SOCS5 in the high…
Using Polymeric Scaffolds for Vascular Tissue Engineering
2014
With the high occurrence of cardiovascular disease and increasing numbers of patients requiring vascular access, there is a significant need for small-diameter (<6 mm inner diameter) vascular graft that can provide long-term patency. Despite the technological improvements, restenosis and graft thrombosis continue to hamper the success of the implants. Vascular tissue engineering is a new field that has undergone enormous growth over the last decade and has proposed valid solutions for blood vessels repair. The goal of vascular tissue engineering is to produce neovessels and neoorgan tissue from autologous cells using a biodegradable polymer as a scaffold. The most important advantage of …
BCL-xL, a Mitochondrial Protein Involved in Successful Aging: From C. elegans to Human Centenarians
2020
B-Cell Lymphoma-extra-large (BCL-xL) is involved in longevity and successful aging, which indicates a role for BCL-xL in cell survival pathway regulation. Beyond its well described role as an inhibitor of apoptosis by preventing cytochrome c release, BCL-xL has also been related, indirectly, to autophagy and senescence pathways. Although in these latter cases, BCL-xL has dual roles, either activating or inhibiting, depending on the cell type and the specific conditions. Taken together, all these findings suggest a precise mechanism of action for BCL-xL, able to regulate the crosstalk between apoptosis, autophagy, and senescence, thus promoting cell survival or cell death. All three pathways…
Sentimientos y teoría de la acción
2001
En el presente trabajo sostenemos que la concepción de la intencionalidad en la teoría de la acción más ampliamente aceptada en la actualidad hace difícil una comprensión adecuada del papel de las emociones en la génesis e interpretación de la acción. La asimilación de las emociones a actitudes intencionales descuida lo que cabría llamar su contenido emocional y pasa por alto importantes diferencias entre su contenido intencional y el de las actitudes intencionales paradigmáticas, como creencias, deseos e intenciones. Sugerimos, sobre esta base, que las relaciones externas y causales deberían tener un lugar más destacado en la comprensión y explicación de las acciones humanas. In this paper…
OPLA scaffold, collagen I, and horse serum induce a higher degree of myogenic differentiation of adult rat cardiac stem cells
2009
In the last few years, a major goal of cardiac research has been to drive stem cell differentiation to replace damaged myocardium. Several research groups have attempted to differentiate potential cardiac stem cells (CSCs) using bi- or three-dimensional systems supplemented with growth factors or molecules acting as differentiating substances. We hypothesize that these systems failed to induce a complete differentiation because they lacked an architectural space. In the present study, we isolated a pool of small proliferating and fibroblast-like cells from adult rat myocardium. The phenotype of these cells was assessed and the characterized cells were cultured in a collagen I/OPLA scaffold …