Search results for "Umana"
showing 10 items of 657 documents
Two isoelectric variants of HSP10 are down-regulated by cigarette smoke exposure in airway cells: A Proteomic study
2008
NOVEL ANTAGONISTS FOR AN Hsp60-BASED ANTICANCER CHAPERONOTHERAPY
2012
The Heat shock proteins (Hsps) are nowadays considered the most important cell chaperones, which result overexpressed in response to a number of cell stress stimuli.In tumor cells, when Hsp60 accumulates in the cytosol, without mitochondrial release, it exerts an anti-apoptotic effect, by inhibiting pro-caspase-3 (pC3) activation. In this context, our study aims to elucidate the structural details of the interaction between Hsp60 and pC3 and to design novel antagonists able to specifically block this interaction. The analysis of virtual screening results highlights the 4-(3-chloro-4-fluorophenylamino)- 6-[(1H-imidazol-4-yl-methyl)-3-carbonitrile-quinolines of type 1 and the N-{5-[1H-imidazo…
CIGARETTE SMOKE EXPOSURE DOWNREGULATES TWO ISOELECTRIC VARIANTS OF HUMAN Hsp10 IN LUNG EPITHELIAL CELLS AND FIBROBLASTS: A PROTEOMIC STUDY.
2008
Hsp10 beyond mitochondria: novel locations predict as yet undescribed roles
2010
Trafficking and secretion patterns of Hsp60 in tumor cells.
2012
The evolutionary course of vertebrate foot, from fish to man
2009
Presence and interaction in tissues of atrial natriuretic peptide,oxytocin and vasopressin:new insights.
2010
Atrial natriuretic peptide, oxytocin and vasopressin are three well known and widely studied molecules since many years. They have been fully characterised from a genetic and biomolecular point of view and a number of receptor-dependent functions have been recognised for them. Nevertheless, in the last years our group has conducted morphologic studies, using an immunohistochemical approach complemented by molecular biology techniques, and could show non-canonical localization and co-localization of these peptides in normal and pathologic tissues, that permitted us to postulate that they may be involved in a wider range of functions than usually assumed and not yet fully understood. In this …
Anatomia clinica del sistema articolare del piede
2006
From a semantic point of view the word “ankle” and “ankle region” are not synonyms as “ankle” identifies all the components of the ankle joint while “ankle region” identifies the ankle joint as well as every structures in the region, form the surface level to the skeletal one. The articular system of the foot is formed by thirthyfour synovial joints, seventeen of which have complementary curvilinear articular surface, the remaning seventeen having plane joints. The rounded surface joints are: the talonavicular joint (a spheroidal joint that is part of the transverse tarsal joint), the “anatomical” subtalar joint ( a saddle joint), five ellipsoid (or condylar) joints and ten, ankle and inter…
Th17-related cytokine expression is increased in the bronchial mucosa of stable COPD patients
2009
Background: There is an increased number of activated Tl lymphocytes in the bronchial mucosa of stable COPD patients but are absent studies on Th17 cells and their effector cytokines.Objectives: To investigate the expression of retinoic orphan receptor(ROR)C2, interleukin(IL)-17A,IL-17F,IL-21,IL-22 and IL-23 in bronchial biopsies from patients with stable COPD of different severity(stage 2 to 4)compared with age-matched control subject(smokers with normal lung function and lifelong non-smokers).Methods: The expression of RORC2,IL-17A,IL-17F,IL-21,IL-22 and IL-23 was measured in the bronchial mucosa using immunohistochemistry and/or real time quantitative polymerase chain reaction. Results: …