Search results for "Umana"
showing 10 items of 657 documents
New frontiers in regenerative medicine in cardiology: the potential of Wharton's jelly mesenchymal stem cells.
2013
Cardiomyopathies are still the first cause of death in the world. The identification of resident stem cells, comprising those derived from sub-endocardial stroma, suggests the possible self regeneration of the heart under autocrine/paracrine modulation in the cardiac microenvironment. Nevertheless, because of the limited in vivo regeneration potential of damaged cardiac tissue, the use of drugs and ultimately cardiac transplantation remain the common treatments of heart diseases and defects. The differentiative potential of embryonic and mesenchymal stem cells (MSCs) derived from different tissues (such as bone marrow and adipose tissue) was extensively explored in cell therapy for regenera…
European Week of Sport: innovative initiative of European Commission that inspires children to be active
2019
BAC KGROU ND: Estimates indicate that more than one third of European adults are inactive, despite the known benefits of physical activity. In 2015 the European Commission launched the European Week of Sport (EWoS), to encourage people to engage in sport and physical activity. The aim of this study was to evaluate if participation in the EWoS could motivate children to participate in physical activity in future. METHOD S: A total of 10,892 children (aged 6-14), from 6 EU cities (Palermo, Italy; Ankara, Turkey; Lousada, Portugal; Gardabaer, Iceland; Rijeka, Croatia; Albacete, Spain), were enrolled in sport activities (running sport event, extra hours of physical activity, seminars on physica…
Hsp27 and Hsp60 in human submandibular salivary gland: Quantitative patterns in healthy and cancerous tissues with potential implications for differe…
2021
Tumors of the submandibular salivary gland (SMG) are uncommon but sufficiently frequent for the physician to consider them in routine examinations and for the pathologist to be prepared to differentiate them from other tissue abnormalities. However, scarcity of specimens makes training difficult, a situation compounded by the lack of accepted universal diagnostic guidelines. Furthermore, there is little information on the chaperone system (CS) of the gland, despite the increasing evidence of its participation in carcinogenesis as a biomarker for diagnosis and patient follow up, and in the mechanisms by which the tumor cells thrive. We are investigating this aspect of various tumors, and her…
The Immunomodulatory Features of Mesenchymal Stromal Cells Derived from Wharton’s Jelly, Amniotic Membrane, and Chorionic Villi In Vitro and In Vivo …
2016
This chapter focuses on the immunomodulatory properties of placental mesenchymal stromal cells (MSCs) derived from the amniotic membrane, umbilical cord, and chorionic villi. Within the amniotic membrane (AM), we discuss the immunomodulatory properties of the two main cell populations that can be isolated from AM: human amniotic mesenchymal stromal cells (hAMSCs) and human amniotic epithelial cells (hAECs). Within the umbilical cord, several compartments have been described, including the amniotic compartment, the Wharton’s jelly (WJ) compartment, and the vascular and perivascular compartment, but herein attention is focused on the properties of human WJ MSCs (hWJMSCs). Since different isol…
Role of CD1A and HSP60 in the antitumoral response of oesophageal cancer
2011
Oesophageal cancer (OC) is one of the most common and severe forms of tumor. A wider knowledge of molecular mechanisms which lead to a normal epithelium becoming a neoplasm may reveal new strategies to improve treatment and outcome of this disease. In this review, we report recent findings concerning molecular events which take place during carcinogenesis of the oesophagus. In particular, we focus on the role of two molecules, CD1a and Hsp60, which are overexpressed in oesophageal and many other types of tumor. Both molecules may present tumor antigens and promote in situ the stimulation of an antitumoral immune activity. We suggest there is a synergistic action between these molecules. Fur…
Lo statuto normativo della dignità umana
2013
L'articolo affronta il problema dei rapporti fra il concetto di dignità umana e il concetto di diritti umani
Il contenuto minimo del realismo morale
2011
Se esiste una “natura umana”, che impone vincoli a ciò che gli uomini possono fare o desiderare, allora esiste verosimilmente un nocciolo di desideri che tutti gli esseri umani hanno, che, verosimilmente, non possono non avere e che non possono desiderare in senso forte di non avere. Tale nocciolo di desideri corrisponde a ciò che, parafrasando Hart, possiamo chiamare il “contenuto minimo del realismo morale”. In tal senso, sosterrò in questo lavoro due tesi. La prima è che il contenuto minimo del realismo morale rappresenta il nocciolo di verità del realismo morale. La seconda tesi è che, esattamente come Hart riconosceva che il contenuto minimo del diritto naturale non confutava le versio…
La forza dell’argomento peggiore. La retorica paternalista nell’argomentazione morale e giuridica
2012
In this essay, I shall analyze some arguments advanced for legal paternalism, which are fallacious or rationally insufficient. Some of the worst arguments for legal paternalism. For example, the argument of life’s sacred value, the argument of human dignity or the argument of common good. Why it is important to defend legal antipaternalism against these arguments? Because they are, in spite of their weakness, rhetorically very used in philosophical, ethical, legal, judicial debate. They likely dissimulate other arguments considered less persuasive, like the theological argument or the moral perfectionist argument for legal paternalism
Effects of conjugated linoleic acid and endurance training on peripheral blood and bone marrow of trained mice
2007
Fat supplements, es- pecially conjugated linoleic acid (CLA), are increasingly popular ergogenic aids among endurance athletes. To evaluate the im- portance of fat supplementation in the practice of endurance sports, we investigated the effects of CLA supplementation on body weight, muscle hypertrophy, peripheral blood composition, and bone marrow composition in healthy, young, endurance- trained mice. Young, healthy mice were subdivided into control, trained, and treated groups, according to their running atti- tudes. Training was performed over a period of 6 weeks on a treadmill, at a gradually increasing duration and speed. CLA- treated groups were gavaged with 0.425 mg·d 1 CLA supplemen…