Search results for "Umana"

Utilidad clínica de la expresión de marcadores inmunohistoquímicos en el tumor vesical urotelial papilar sin invasión de la muscular propia (pTa/pT1)…

2015

Introducción: El tumor vesical urotelial papilar sin invasión de la muscular propia (TVU NoMinv) es uno de los tumores urológicos más frecuentes. A pesar del tratamiento, presenta una elevada tasa de recidiva y progresión. El hallazgo de factores pronósticos que nos indiquen su comportamiento clínico es fundamental para estratificar riesgos y ayudar al diseño de una estrategia terapéutica. Las variables anatomoclínicas clásicamente utilizadas no son del todo precisas en la evaluación pronóstica. La nueva clasificación histológica de la OMS 2004 tampoco ha conseguido este objetivo, presentando una importante variabilidad interobservador. Por ello, está en auge el estudio de marcadores molecu…

Influencia de la obesidad infantil sobre el control postural y la marcha

2019

OBJETIVO El objetivo principal de este trabajo es estudiar la influencia de la masa adiposa sobre el control postural y la marcha en niños con sobrepeso y obesidad. Así como poder determinar las diferencias en el control postural que existen entre estos y los niños normopeso (sin sobrepeso ni obesidad). METODOLOGÍA Se realizaron 3 estudios con un grupo de sujetos de unos 12 años de edad. A su vez, este se dividió en dos grupos: con obesidad o sobrepeso y sin obesidad o sobrepeso. A todos se les midió el peso con una plataforma de fuerzas (Dinascan/IBV, Instituto Biomecánica de Valencia, Valencia, España) y la altura con un tallímetro. Al grupo con obesidad también se les midió la composició…

A lower-limb training program to improve balance in healthy elderly women using the T-Bow® Device

2009

Ageing impairs balance, which increases the risk of falls. Fall-related injuries are a serious health problem associated with dependency and disability in the elderly and results in high costs to public health systems. This study aims to determine the effects of a training program to develop balance using a new device called the T-Bow (R). A total of 28 women > 65 years were randomly assigned to an experimental group (EG) (n = 18; 69.50 [0.99] years), or a control group (CG) (n = 10; 70.70 [2.18] years). A program for lower limbs was applied for 8 weeks using 5 exercises on the T-Bow (R): squat, lateral and frontal swings, lunges, and plantarflexions. The intensity of the exercises was cont…

Fasting-mimicking diet prevents high-fat diet effect on cardiometabolic risk and lifespan

2021

Diet-induced obesity is a major risk factor for metabolic syndrome, diabetes and cardiovascular disease. Here, we show that a 5-d fasting-mimicking diet (FMD), administered every 4 weeks for a period of 2 years, ameliorates the detrimental changes caused by consumption of a high-fat, high-calorie diet (HFCD) in female mice. We demonstrate that monthly FMD cycles inhibit HFCD-mediated obesity by reducing the accumulation of visceral and subcutaneous fat without causing loss of lean body mass. FMD cycles increase cardiac vascularity and function and resistance to cardiotoxins, prevent HFCD-dependent hyperglycaemia, hypercholesterolaemia and hyperleptinaemia and ameliorate impaired glucose and…

Effects of three different water temperatures on dehydration in competitive swimmers

2011

Summary Aims The purpose of this study was to evaluate the effects of three different water temperatures on physiological responses (dehydration, sweat rate, urine output, rectal temperature and plasma electrolytes) of competitive athletes during a “simulated” race of 5 km in an indoor swimming pool. Methods Nine male competitive master swimmers swam 5 km with the water at temperatures of 23, 27 and 32 C. Immediately before (Pre) and after (Post) each trial, samples of blood and urine were collected, body weight was recorded and rectal temperature was measured. The dehydration percentage and sweat rate were the highest at 32 C and the lowest at 23 C (23 C: −0.9 ± 0.5; 27 C: −1.3 ± 0.6; 32 C…

Cytoskeleton mediates negative inotropism and lusitropism of chromogranin A-derived peptides (human vasostatin1-78 and rat CgA(1-64)) in the rat heart

2010

Cytoskeleton scaffold in cardiac myocytes provides structural support and compartmentalization of intracellular components. It is implicated in cardiac pathologies including hypertrophy and failure, playing a key role in the determinism of contractile and diastolic dysfunctions. Chromogranin A (CgA) and its derived peptides have revealed themselves as novel cardiovascular modulators. In humans, normal CgA levels considerably increase in several pathologies, including heart failure. Recent data have shown on the unstimulated rat heart that human recombinant Vasostatin-1 (hrVS-1) and rat chromogranin A 1-64 (rCgA(1-64)) induce negative inotropic and lusitropic effects counteracting the beta-a…

Oxidative stress induces myeloperoxidase expression in endocardial endothelial cells from patients with chronic heart failure.

2009

Increased oxidative stress has been implicated in the pathogenesis of a number of cardiovascular diseases. Recent findings suggest that myeloperoxidase (MPO) may play a key role in the initiation and maintenance of chronic heart failure (CHF) by contributing to the depletion of the intracellular reservoir of nitric oxide (NO). NO consumption through MPO activity may lead to protein chlorination or nitration, leading to tissue damage. Primary cultures of human endocardial endothelial cells (EEC) obtained at heart transplantation of patients with CHF and human umbilical vein endothelial cells (HUVEC) were subjected to oxidative stress by incubation with hydrogen peroxide at non lethal (60 mic…

Effects of Sulpiride Treatment on the Hypothalamic Supraoptic and Paraventricular Nuclei

2009

Insights on Central and Peripheral Venous Catheterization; Biology, Anatomy, Surgical Aspects and Nursing Management (Our Experience)

2009

After a review of the main anatomical districts of relevance to central and peripheral venous catheterization, we analyze the primary guidelines for the management of cannulation of central and peripheral venous catheters; a background study relative to this subject is then carried out. The aim of the present study is to review the main central and peripheral catheterization methods, and to share our experience with particular emphasis on analyzing common complications

BENEFICIAL EFFECT OF PROBIOTICS ADMINISTRATION IN INFLAMMATORY BOWEL DISEASE AND RELATED SPONDYLOARTHROPATHY: A PROSPECTIVE STUDY

2015

Background: Therapeutic treatment for inflammatory bowel disease (IBD) may follow different approaches, systemic as well as local, especially when the target is the osteoarticular apparatus. Although some clinical trials have suggested benefits from probiotics administration in IBD, there is still a great deal of controversy on their use. The aim of this study was to further investigate the effects of probiotics in patients with IBD and related spondyloarthropathy. Material/Methods: Fifty-nine patients affected by IBD with extra-intestinal involvement where evaluated from 2006 to 2010. Twenty-eight patients received administration of a standard therapy with mesalazine and 31 where treated w…