Search results for "Uncertainty"

The Raising Factor, That Great Unknown. A Guided Activity for Undergraduate Students

2020

In the first years of their economics degree programs, students will face many problems successfully dealing with a range of subjects with quantitative content. Specifically, in the field of statistics, difficulties to reach some basic academic achievements have been observed. Hence, a continuing challenge for statistics teachers is how to make this subject more appealing for students through the design and implementation of new teaching methodologies. The latter tend to follow two main approaches. On the one hand, it is useful for the learning process to propose practical activities that can connect theoretical concepts with real applications in the economic context. On the other hand, we …

Symmetrised M-estimators of multivariate scatter

2007

AbstractIn this paper we introduce a family of symmetrised M-estimators of multivariate scatter. These are defined to be M-estimators only computed on pairwise differences of the observed multivariate data. Symmetrised Huber's M-estimator and Dümbgen's estimator serve as our examples. The influence functions of the symmetrised M-functionals are derived and the limiting distributions of the estimators are discussed in the multivariate elliptical case to consider the robustness and efficiency properties of estimators. The symmetrised M-estimators have the important independence property; they can therefore be used to find the independent components in the independent component analysis (ICA).

Causal diagrams for empirical research

1995

Study Design in Causal Models

2014

The causal assumptions, the study design and the data are the elements required for scientific inference in empirical research. The research is adequately communicated only if all of these elements and their relations are described precisely. Causal models with design describe the study design and the missing-data mechanism together with the causal structure and allow the direct application of causal calculus in the estimation of the causal effects. The flow of the study is visualized by ordering the nodes of the causal diagram in two dimensions by their causal order and the time of the observation. Conclusions on whether a causal or observational relationship can be estimated from the coll…

R Graphics (3rd Edition)

2020

Multi-omics HeCaToS dataset of repeated dose toxicity for cardiotoxic & hepatotoxic compounds.

2022

The data currently described was generated within the EU/FP7 HeCaToS project (Hepatic and Cardiac Toxicity Systems modeling). The project aimed to develop an in silico prediction system to contribute to drug safety assessment for humans. For this purpose, multi-omics data of repeated dose toxicity were obtained for 10 hepatotoxic and 10 cardiotoxic compounds. Most data were gained from in vitro experiments in which 3D microtissues (either hepatic or cardiac) were exposed to a therapeutic (physiologically relevant concentrations calculated through PBPK-modeling) or a toxic dosing profile (IC20 after 7 days). Exposures lasted for 14 days and samples were obtained at 7 time points (therapeutic…

Estimates of Regression Coefficients Based on the Sign Covariance Matrix

2002

SummaryA new estimator of the regression parameters is introduced in a multivariate multiple-regression model in which both the vector of explanatory variables and the vector of response variables are assumed to be random. The affine equivariant estimate matrix is constructed using the sign covariance matrix (SCM) where the sign concept is based on Oja's criterion function. The influence function and asymptotic theory are developed to consider robustness and limiting efficiencies of the SCM regression estimate. The estimate is shown to be consistent with a limiting multinormal distribution. The influence function, as a function of the length of the contamination vector, is shown to be linea…

Estimation of the Combined Effects of Ageing and Seasonality on Mortality Risk: An Application to Spain

2021

Abstract Despite the overwhelming evidence that shows the persistence of intra-annual variations on demographic events (deaths, birth dates and migration flows), life tables are computed and provided on an annual basis. This paper develops a new estimator for estimating sub-annual death rates that, considering the exact moment of occurrence (exact age and day) of events, concurrently accounts for ageing and calendar fluctuations. This paper also shows how modelling the intra-annual variations of death rates, through specific seasonal–ageing indexes, can be used as a tool for constructing new sub-annual tables from annual tables. This new methodology is exemplified using a real database of S…

Model-Assisted Estimation Through Random Forests in Finite Population Sampling

2021

In surveys, the interest lies in estimating finite population parameters such as population totals and means. In most surveys, some auxiliary information is available at the estimation stage. This information may be incorporated in the estimation procedures to increase their precision. In this article, we use random forests (RFs) to estimate the functional relationship between the survey variable and the auxiliary variables. In recent years, RFs have become attractive as National Statistical Offices have now access to a variety of data sources, potentially exhibiting a large number of observations on a large number of variables. We establish the theoretical properties of model-assisted proc…

Balanced Asymmetrical Nearly Orthogonal Designs for first and second order effect estimation

2006

Abstract A method for constructing asymmetrical (mixed-level) designs, satisfying the balancing and interaction estimability requirements with a number of runs as small as possible, is proposed in this paper. The method, based on a heuristic procedure, uses a new optimality criterion formulated here. The proposed method demonstrates efficiency in terms of searching time and optimality of the attained designs. A complete collection of such asymmetrical designs with two- and three-level factors is available. A technological application is also presented.