Search results for "Unity"

How Fragile We Are: Influence of Stimulator of Interferon Genes (STING) Variants on Pathogen Recognition and Immune Response Efficiency.

2022

AbstractThe STimulator of INterferon Genes (STING) protein is a cornerstone of the human immune response. Its activation by cGAMP upon the presence of cytosolic DNA stimulates the production of type I interferons and inflammatory cytokines which are crucial for protecting cells from infections. STING signaling pathway can also influence both tumor-suppressive and tumor-promoting mechanisms, rendering it an appealing target for drug design. In the human population, several STING variants exist and exhibit dramatic differences in their activity, impacting the efficiency of the host defense against infections. Understanding the differential molecular mechanisms exhibited by these variants is o…

The role of rock mining for maintaining Dauco carotae-Crepidetum rhoeadifoliae Hejný et Grüll in Hejný et al. 1979 — a new to Poland plant association

2013

AbstractThis work presents the Dauco carotae-Crepidetum rhoeadifoliae plant association, which is new to Poland. The association has been observed in industrial reclamation areas in the vicinity of carbonate mineral excavation sites in the central part of the Opole region. In the vast majority of cases, plots of this association developed in reclaimed areas. The majority of diagnostic species for the association was found within surveyed plots, including Verbascum thapsus, V. densiflorum and Bryum argenteum. Taxa characteristic of the alliance were also constantly present, i.e. Daucus carota, Melilotus alba, M. officinalis, Echium vulgare and Erysimum hieracifolium. This association belongs…

Critical stance within a community of inquiry in an advanced mathematics course for pre-service teachers

2020

AbstractThis paper reports a study of university students’ experiences of learning mathematics in an introductory differential equations course that takes an inquiry approach to learning and teaching. The students are on a trajectory leading toward a bachelor’s degree in mathematics to be followed by a year-long teacher education credential program. The analysis of students’ end of course presentations and written portfolios is framed with community of practice theory, complemented with analytic categories from community of inquiry, including notions of inquiry stance and critical alignment. Our social theorization of university mathematics education adds a complementary perspective to the …

Bridges: A World Community for Mathematical Art

2016

Advances on Cellular Clonotypic Immunity in Amyotrophic Lateral Sclerosis.

2022

Amyotrophic lateral sclerosis (ALS) is a fatal neuromuscular disease, characterized by the progressive degeneration of the upper and lower motor neurons in the cortex and spinal cord. Although the pathogenesis of ALS remains unclear, evidence concerning the role of the clonotypic immune system is growing. Adaptive immunity cells often appear changed in number, or in terms of their activation profiles, both peripherally and centrally; however, their role in ALS appears conflictive. Data from human and animal model studies, which are currently reported in the literature, show that each subset of lymphocytes and their mediators may mediate a protective or toxic mechanism in ALS, affecting both…

Typhetum laxmannii (Ubrizsy 1961) Nedelcu 1968 - The new plant association in Poland

2011

<em>Typhetum laxmannii</em> (Ubrizsy 1961) Nedelcu 1968 is a plant association new to Poland, built by an expansive kenophyte - <em>Typha laxmannii</em> Lepech. This paper presents the general distribution of both, the species and the association, paying particular attention to the area of Europe and Poland where, in recent years, many new locations as well as an increasing participation in vegetation cover have been observed. The habitat preferences of <em>Typhetum laxmannii</em>, the floristic composition of the association and its geographical differentiation within the occupied area are described. The current distribution of the association in Poland …

What seems to be the problem?—A study of connections between national contexts and regional e-health strategies

2015

Abstract Motivation Different e-health strategies may produce different long-term results, so it is of general interest to look into strategies behind e-health approaches, and what factors that influence strategy-formation. Problem statement Previous studies into process improvements in the e-health area has suggested that approaches and strategies are very dependent on national contexts. This study explores this issue, by sampling two national regions in Europe, the St. Gallen region and canton in Switzerland, and the Agder region comprised of the two Agder-counties, in Norway. The research questions revolve around the extent to which the context influences e-health innovation in two diffe…

Does persistence in using R&D tax credits help to achieve product innovations?

2021

Despite the generosity of its tax system, Spain is far from EU countries in terms of R&D spending and innovation outcomes. A policy instrument commonly used to foster firms’ R&D investment are tax incentives. The use of this instrument is not generalized in firms spending on R&D, and only a fraction of firms are regular claimants. This paper investigates whether persistence in using tax credits is positively related to product innovations, beyond R&D investments. We consider that firms investing in qualified R&D and using tax credits regularly are likely to be firms aiming at innovating. By contrast, occasional tax credit users may be firms investing in R&D for different reasons, such as ex…

Preemptive CD8 T-Cell Immunotherapy of Acute Cytomegalovirus Infection Prevents Lethal Disease, Limits the Burden of Latent Viral Genomes, and Reduce…

1998

ABSTRACT In the immunocompetent host, primary cytomegalovirus (CMV) infection is resolved by the immune response without causing overt disease. The viral genome, however, is not cleared but is maintained in a latent state that entails a risk of virus recurrence and consequent organ disease. By using murine CMV as a model, we have shown previously that multiple organs harbor latent CMV and that reactivation occurs with an incidence that is determined by the viral DNA load in the respective organ (M. J. Reddehase, M. Balthesen, M. Rapp, S. Jonjic, I. Pavic, and U. H. Koszinowski. J. Exp. Med. 179:185–193, 1994). This predicts that a therapeutic intervention capable of limiting the load of lat…

pcaH, a molecular marker for estimating the diversity of the protocatechuate-degrading bacterial community in the soil environment

2007

Microorganisms degrading phenolic compounds play an important role in soil carbon cycling as well as in pesticide degradation. The pcaH gene encoding a key ring-cleaving enzyme of the -ketoadipate pathway was selected as a functional marker. Using a degenerate primer pair, pcaH fragments were cloned from two agricultural soils. Restriction fragment length polymorphism (RFLP) screening of 150 pcaH clones yielded 68 RFLP families. Comparison of 86 deduced amino acid sequences displayed 70% identity to known PcaH sequences. Phylogenetic analysis results in two major groups mainly related to PcaH sequences from Actinobacteria and Proteobacteria phyla. This confirms that the developed primer pai…