Search results for "Unity"
showing 10 items of 3852 documents
Exploring a regulatory role for mast cells: 'MCregs'?
2010
Regulatory cells can mould the fate of the immune response by direct suppression of specific subsets of effector cells, or by redirecting effectors against invading pathogens and infected or neoplastic cells. These functions have been classically, although not exclusively, ascribed to different subsets of T cells. Recently, mast cells have been shown to regulate physiological and pathological immune responses, and thus to act at the interface between innate and adaptive immunity assuming different functions and behaviors at discrete stages of the immune response. Here, we focus on these poorly defined, and sometimes apparently conflicting, functions of mast cells.
Antipredatory function of head shape for vipers and their mimics.
2011
Most research into the adaptive significance of warning signals has focused on the colouration and patterns of prey animals. However, behaviour, odour and body shape can also have signal functions and thereby reduce predators' willingness to attack defended prey. European vipers all have a distinctive triangular head shape; and they are all venomous. Several non-venomous snakes, including the subfamily Natricinae, commonly flatten their heads (also known as head triangulation) when disturbed. The adaptive significance of this potential behavioural mimicry has never been investigated. We experimentally tested if the triangular head shape typical of vipers offers protection against predation.…
Qualitative Comparison of Community Detection Algorithms
2011
Community detection is a very active field in complex networks analysis, consisting in identifying groups of nodes more densely interconnected relatively to the rest of the network. The existing algorithms are usually tested and compared on real-world and artificial networks, their performance being assessed through some partition similarity measure. However, artificial networks realism can be questioned, and the appropriateness of those measures is not obvious. In this study, we take advantage of recent advances concerning the characterization of community structures to tackle these questions. We first generate networks thanks to the most realistic model available to date. Their analysis r…
Gene expression specificity of the mussel antifungal mytimycin (MytM)
2011
Abstract We previously reported the nucleotide sequences and diversity of mytimycin (MytM) from the Mediterranean mussel, Mytilus galloprovincialis. Using real-time PCR (q-PCR), we observed that the MytM gene was mainly expressed in circulating hemocytes and to a less extent in the mantle. In vivo challenge with bacteria or with the yeast, Candida albicans, did not increase the expression as measured by q-PCR in hemocytes. By contrast, injection of the filamentous fungus, Fusarium oxysporum, induced a sudden and strong increase of expression at 9h p.i. (stimulation index of 25.7 ± 2.1). Optimum stimulating dose was 104 spores of F. oxysporum per mussel. In the same samples, AMP mytilin and …
Response to reindeer grazing removal depends on soil characteristics in low Arctic meadows
2014
In Arctic tundra, grazing is expected to exert a positive influence on microbial activity thus enhancing nutrient cycling and promoting the presence of high productive graminoids. We investigated the changes occurring in two low Arctic meadow sites after 10 years exclusion from grazing. We compared plant, soil fauna and microbial community composition, extracellular enzymes activities, and soil nutrients in ungrazed and adjacent grazed area in two low Arctic meadows. The two closely located experimental sites were both dominated by the common grass Deschampsia flexuosa which covered more than 50% of the meadows. Plant community was affected significantly by site and grazing, but the effect …
FGFR a promising druggable target in cancer: Molecular biology and new drugs.
2017
Abstract: Introduction: The Fibroblast Growth Factor Receptor (FGFR) family consists of Tyrosine Kinase Receptors (TKR) involved in several biological functions. Recently, alterations of FGFR have been reported to be important for progression and development of several cancers. In this setting, different studies are trying to evaluate the efficacy of different therapies targeting FGFR. Areas Covered: This review summarizes the current status of treatments targeting FGFR, focusing on the trials that are evaluating the FGFR profile as inclusion criteria: Multi-Target, Pan-FGFR Inhibitors and anti-FGF (Fibroblast Growth Factor)/FGFR Monoclonal Antibodies. Expert opinion: Most of the TKR share …
Análisis de conocimientos sobre aulas de comunicación y lenguaje de futuros/as maestros/as.
2021
Resumen basado en el de la publicación Título, resumen y palabras clave en español y en inglés Uno de los recursos regulados para la adecuada inclusión de alumnado con necesidades específicas de apoyo educativo (NEAE) en centros educativos ordinarios en la Comunidad Valenciana son las aulas de comunicación y lenguaje (CyL). El éxito de este recurso depende, entre otros aspectos, de los conocimientos que tenga el profesorado tanto generalista como especialista sobre su funcionamiento. Se analizan los conocimientos, los errores y las lagunas de los estudiantes de último curso de los grados de Maestro/a en Educación Infantil y de Maestro/a en Educación Primaria sobre el funcionamiento de estas…
Resistance to demineralisation of adjacent enamel and dentine, fluoride release and dentine bond strength of fluoride-containing self-etch adhesive s…
2019
Background The current study aimed to assess the amount of fluoride released from fluoride-containing dental adhesives and its effect on micro-tensile bond strength (µTBS) and on resistance to demineralisation of dentine and enamel. Material and Methods Two fluoride-containing dental adhesives, and a fluoride-free adhesive were used as experimental adhesives. After thermal cycling the µ-TBS of adhesives to dentine and the failure mode were assessed. The fluoride release and cross-sectional microhardness (CSMH) of specimens were measured before and after one day, 7 and 28 days of pH-cycling. The data were analysed using one-way ANOVA, Weibull statistics and repeated measures ANOVA. Results T…
Guinea pig transglutaminase immunolinked assay does not predict coeliac disease in patients with chronic liver disease
2001
BACKGROUND—It has been suggested that serological screening for coeliac disease (CD) should be performed in patients with chronic unexplained hypertransaminasaemia. AIMS—To evaluate the specificity for CD diagnosis of serum IgA antitissue transglutaminase (tTG) determination in consecutive patients with chronic hypertransaminasaemia using the most widely utilised ELISA based on tTG from guinea pig as the antigen. PATIENTS AND METHODS—We studied 98 patients with chronic hypertransaminasaemia, evaluated for the first time in a hepatology clinic. Serum anti-tTG and antiendomysial (EmA) assays were performed. Patients positive for EmA and/or anti-tTG were proposed for intestinal biopsy. Finally…
Identifying potential areas of expansion for the endangered brown bear (Ursus arctos) population in the cantabrian mountains (NW Spain)
2019
Many large carnivore populations are expanding into human-modified landscapes and the subsequent increase in coexistence between humans and large carnivores may intensify various types of conflicts. A proactive management approach is critical to successful mitigation of such conflicts. The Cantabrian Mountains in Northern Spain are home to the last remaining native brown bear (Ursus arctos) population of the Iberian Peninsula, which is also amongst the most severely threatened European populations, with an important core group residing in the province of Asturias. There are indications that this small population is demographically expanding its range. The identification of the potential are…