Search results for "Unity"
showing 10 items of 3852 documents
Research on complement: old issues revisited and a novel sphere of influence
2003
Immunology in recent years has taken a somewhat surprising turn, expressed by a renewed interest in innate immunity. Especially intriguing is the regulatory role exerted by the innate components on the adaptive response, with Toll receptors and complement components being the most investigated. This function has been firmly established for complement protein CR2 (CD21) as part of the BCR co-receptor CD19/CD21/CD81. New findings are now providing a broader picture of complement and its tuning of the immune response; for example, complement proteins have been implicated in the control of T-cell-mediated responses. We will review some of these data here and summarize new discoveries in areas o…
Weevils (Coleoptera: Curculionoidea) of the Stobrawski Landscape Park
2011
Weevils (Coleoptera: Curculionoidea) of the Stobrawski Landscape ParkThe work presents the results of faunistic and ecological studies on the weevils (Coleoptera: Curculionoidea without Scolytinae) of the Stobrawski Landscape Park. Between 2006-2008 more than 4 000 specimens representing 285 species of weevils were collected from nine types of plant communities.Mesotrichapion punctirostre, Nanophyes brevis, Otiorhynchus lepidopterus, Phytobius leucogaster, Rhaphitropis marchicuswere collected for the first time in Lower or Upper Silesia. The geographical, habitat and food preferences of particular species are presented. The relationships between weevil species and the different habitats are…
Local delivery of mRNA-encoded cytokines promotes antitumor immunity and tumor eradication across multiple preclinical tumor models
2021
Local immunotherapy ideally stimulates immune responses against tumors while avoiding toxicities associated with systemic administration. Current strategies for tumor-targeted, gene-based delivery, however, are limited by adverse effects such as off-targeting or antivector immunity. We investigated the intratumoral administration of saline-formulated messenger (m)RNA encoding four cytokines that were identified as mediators of tumor regression across different tumor models: interleukin-12 (IL-12) single chain, interferon-α (IFN-α), granulocyte-macrophage colony-stimulating factor, and IL-15 sushi. Effective antitumor activity of these cytokines relied on multiple immune cell populations and…
Tumor vaccination using messenger RNA: prospects of a future therapy.
2011
While the endeavor to vaccinate against cancer has been pursued for over 20 years, only recently was the first tumor vaccine approved. Among the different antigen formats assessed for vaccination, coding messenger RNA (mRNA) is emerging as a particularly attractive option. It can code for all types of transcript based proteins, is easy and cost efficient to produce, has a favorable safety profile and enables induction of combined immune responses. Within the last few years major developments have been achieved in this field. Clinical approaches use mRNA either for direct administration or for engineering of adoptively transferred dendritic cells. However, there are still challenges to be ov…
Wood-inhabiting fungal communities : Opportunities for integration of empirical and theoretical community ecology
2022
Publisher Copyright: © 2021 The Author The interest in studying wood-inhabiting fungal communities has grown in recent years. This interest has mainly been motivated by the important roles of wood-inhabiting fungi in ecosystem functioning (e.g. nutrient cycling) and conservation biology (e.g. their sensitivity to forest management). In this paper, I argue that another important, but yet largely unexplored motivation for studying wood-inhabiting fungal communities, is their potential to advance fundamental community ecology. One major advantage of wood-inhabiting fungi as model systems is that they are organized as spatially well-defined metacommunities, thus conforming to the assumptions of…
Zooplankton biodiversity and community structure vary along spatiotemporal environmental gradients in restored peridunal ponds
2015
<p>Zooplankton assemblages in neighboring ponds can show important spatial and temporal heterogeneity. Disentangling the influence of regional versus local factors, and of deterministic versus stochastic processes has been recently highlighted in the context of the metacommunity theory. In this study, we determined patterns of temporal and spatial variation in zooplankton diversity along one hydrological year in restored ponds of different hydroperiod and age. The following hypotheses regarding the assembling of species over time were tested: i) dispersal is not limited in our study system due to its small area and high exposure to dispersal vectors; ii) community dissimilarity among …
The long history of rich fens supports persistence of plant and snail habitat specialists
2021
Increasing evidence for the effects of Holocene history on modern biotic communities suggests that current explanations of community patterns and conservation strategies require revisiting. Here we focused on Central European rich fens that are at high risk among mire habitats because of their relatively low environmental stability, and hence sensitivity to successional shifts. At each of 57 study sites, inventory of specialist species of bryophytes, vascular plants and land snails, measurements of local environmental conditions, area, and radiocarbon dating were conducted. We used Moran’s I spatial autocorrelation, multiple linear regression models, MDS, db-RDA, and null models to identify…
The effects of habitat degradation on metacommunity structure of wood-inhabiting fungi in European beech forests
2013
Intensive forest management creates habitat degradation by reducing the variation of forest stands in general, and by removing old trees and dead wood in particular. Non-intervention forest reserves are commonly believed to be the most efficient tool to counteract the negative effects on biodiversity, but actual knowledge of the conservation efficiency is limited, especially for recent reserves. The structure of ecological communities is often described with measures of nestedness, beta diversity and similarity between communities. We studied whether these measures differ among forest reserves with different management histories. For this purpose, we used a large data set of wood-inhabiting…
Effects of environmental and spatial variables on lotic ostracod metacommunity structure in the Iberian Peninsula
2015
The heterogeneous distribution of aquatic species in lotic environments has been studied little in terms of metacommunity theory. Previous empirical tests have found significant spatial and environmental effects in pond and lake communities, but this has not yet been clearly established for stream networks. We conducted a multi-season survey of mountain streams in the Iberian Peninsula. We recorded GIS and in situ environmental data and collected biological samples to determine ostracods and macroinvertebrates and identified 41 ostracod species, the most common belonging to genera Herpetocypris , Sarscypridopsis , and Ilyocypris . A generalized linear model analysis showed that thermal rang…
Metal drugs and the anticancer immune response
2018
The immune system deploys a multitude of innate and adaptive mechanisms not only to ward off pathogens but also to prevent malignant transformation ("immune surveillance"). Hence, a clinically apparent tumor already reflects selection for those malignant cell clones capable of evading immune recognition ("immune evasion"). Metal drugs, besides their well-investigated cytotoxic anticancer effects, massively interact with the cancer-immune interface and can reverse important aspects of immune evasion. This topic has recently gained intense attention based on combination approaches with anticancer immunotherapy (e.g., immune checkpoint inhibitors), a strategy recently delivering first exciting…