Search results for "Unity"
showing 10 items of 3852 documents
The new configuration of the Valencian party system. An institutional approach
2018
International audience; The main objective of this article is to explain the evolution of the party system of the Valencian Community (Spain) between 1978 and 2015. We will start from a historical neo-institutionalist approach and a methodology focused on historical analysis (path dependence and critical junctures). It will be centered on the changes produced in political parties, in terms of the Valencian cartelization and identity and its present position. This way, three working sub-hypotheses are to be explained: H1a: parties have had a continuity dynamic that has changed due to abrupt changes in the environment; H1b: political forces have taken advantage of these events to obtain elect…
Altered intracellular sorting signals do not influence the efficacy of genetic melanoma vaccines incorporating helper determinants in mice.
2004
Background A genetic melanoma vaccine consisting of cDNA encoding the model self-antigen tyrosinase-related protein 2 (TRP2) fused in-frame to the immunogenic enhanced green fluorescent protein (EGFP) was able to break immune tolerance and stimulate CD8+ T cells in vivo. In the present study we investigated whether alteration of the intracellular antigen localization as a result of the linkage with immune-enhancing helper proteins affects the resulting immune response. Methods Expression plasmids and recombinant adenoviruses were constructed encoding various fusion proteins with different intracellular sorting signals which direct the antigen to the cytosol, the endoplasmic reticulum or the…
Eroded enamel rehardening using two intraoral appliances designs in different times of salivary exposure.
2019
Background The aim of this study was evaluated the eroded enamel rehardening potential using upper palatal and lower buccal removable appliances in different times of salivary exposure (30 min, 1h, 2h, 12h) after a single erosive challenge event. Material and Methods After initial surface hardness evaluation, bovine enamel blocks were eroded in vitro (0.01 M hydrochloric acid, pH 2.3, 30 seconds), selected (n = 160) and randomly assigned to the two appliance designs and twenty volunteers. Four enamel blocks were inserted in each removable appliance. On the in situ phase, the volunteers were instructed to use the upper palatal and lower buccal appliances simultaneously for 12 nonconsecutive …
RNAi mediated acute depletion of Retinoblastoma protein (pRb) promotes aneuploidy in human primary cells via micronuclei formation
2009
BACKGROUND: Changes in chromosome number or structure as well as supernumerary centrosomes and multipolar mitoses are commonly observed in human tumors. Thus, centrosome amplification and mitotic checkpoint dysfunctions are believed possible causes of chromosomal instability. The Retinoblastoma tumor suppressor (RB) participates in the regulation of synchrony between DNA synthesis and centrosome duplication and it is involved in transcription regulation of some mitotic genes. Primary human fibroblasts were transfected transiently with short interfering RNA (siRNA) specific for human pRb to investigate the effects of pRb acute loss on chromosomal stability. RESULTS: Acutely pRb-depleted fibr…
Shared Administration for Smart Cities
2016
Within the paradigm of Smart Cities, the role played by urban communities is becoming ever more crucial. This chapter, in particular, explores the paradigm of “Shared administration” as the most effective urban governance model that helps urban communities to operate as smart communities taking care and regenerating common urban spaces. According to this administrative culture, the “Regulation for collaboration between citizens and administration” and the “Pact” are measures to implement practical opportunities to empower citizens, to free their energies and to enhance their knowledge and competences in a renewed alliance with the public institutions.
Being successful in the world of narrow opportunities: transmission patterns of the trematode Ichthyocotylurus pileatus.
2009
SUMMARYParasites with complex life cycles face 2 major challenges for transmission in northern latitudes. They have to cope with the general unpredictability associated with the series of transmission events required for completion of the cycle, and transmission has to be completed within a narrow temporal window because of strong seasonality. Despite this, some parasites show high transmission success, suggesting the operation of effective transmission mechanisms. We explored the transmission of Ichthyocotylurus pileatus (Trematoda) from its snail (Valvata macrostoma) to fish (Perca fluviatilis) hosts by examining some key characteristics in the dynamics of the cercarial emergence from sna…
Studying micro-communities in Facebook Communities
2018
In the visionary view of the future Internet, named the Next Generation Internet, a current idea is to have a user-centric approach where human behavior models will be used to define the networks or to manage services. During the last years, a great trend in current Social Media platforms is to offer the opportunity to establish and join groups of people online. Despite human behaviour in current Online Social Media have been studied in depth, characteristics of these aggregations of people in content-based communities are still unknown. In this paper, we propose an evaluation of micro-communities of users inside the big network of Facebook groups to understand how and when users are active…
La deduzione personalistica della democrazia nella pedagogia di Luigi Stefanini
2021
Through a historical reading of the Luigi Stefanini’s philosophy (Treviso 1891 - Padua 1956), this paper presents the democratic theory of education that he elaborates in the years of the Reconstruction. Stefanini proposes a personalistic deduction of democracy, where the educational act becomes a place of event of the social person. Education for democracy coincides with a path of spiritual growth that causes the person in the individual and that has a mystical foundation: first the ego experiences itself and then meets others as similar but singular subjects. In this educational process the teacher is very important, because he acts as an intermediary between the disciple and the absolute…
Predictive value of the Merrill-Palmer-R Scale applied during the first year of live
2016
Resumen basado en el de la publicación Títulos, resumen y palabras clave en inglés y español El valor predictivo de una escala de desarrollo utilizado durante el primer año de vida es de gran interés en la planificación de las intervenciones tempranas. El valor predictivo de un instrumento es la probabilidad de acertar el diagnóstico de trastorno o retraso en el desarrollo de un niño. Se analizaron las puntuaciones de escala Merrill-Palmer-R (MP-R) en una muestra de 291 niños menores de un año de la Comunidad Valenciana. A pesar de que no se distribuyen normalmente las puntuaciones de la escala MP-R en esta muestra, los resultados predichos eran buenos. Además, las puntuaciones de desarroll…
The welfare of immigrants: Resilience and sense of community
2021
The accessibility to national health services by immigrants residing in our country has produced a widespread improve- ment of health indicators and health prevention for the entire population. The main goal of this study is to investigate the welfare conditions of immigrants, alongside two fundamental sources of psychological resources. In particular, the role of resilience and sense of community as protective factors against the risk of developing negative welfare outcomes, including life satisfaction and the perception of general health (physical and mental), were considered as indicators. The following self- report questionnaires were sent to a sample of 354 immi- grants, stratified by …