Search results for "Unity"

Plasmacytoid dendritic cells are inefficient in activation of human regulatory T cells

2011

BACKGROUND: Dendritic cells (DC) play a key role in initiation and regulation of immune responses. Plasmacytoid DC (pDC), a small subset of DC, characterized as type-I interferon producing cells, are critically involved in anti-viral immune responses, but also mediate tolerance by induction of regulatory T cells (Treg). In this study, we compared the capacity of human pDC and conventional DC (cDC) to modulate T cell activity in presence of Foxp3(+) Treg. PRINCIPAL FINDINGS: In coculture of T effector cells (Teff) and Treg, activated cDC overcome Treg anergy, abrogate their suppressive function and induce Teff proliferation. In contrast, pDC do not break Treg anergy but induce Teff prolifera…

Direct Activation of Bax by p53 Mediates Mitochondrial Membrane Permeabilization and Apoptosis

2004

The tumor suppressor p53 exerts its anti-neoplastic activity primarily through the induction of apoptosis. We found that cytosolic localization of endogenous wild-type or trans-activation–deficient p53 was necessary and sufficient for apoptosis. p53 directly activated the proapoptotic Bcl-2protein Bax in the absence of other proteins to permeabilize mitochondria and engage the apoptotic program. p53 also released both proapoptotic multidomain proteins and BH3-only proteins [Proapoptotic Bcl-2family proteins that share only the third Bcl-2homology domain (BH3)] that were sequestered by Bcl-xL. The transcription-independent activation of Bax by p53 occurred with similar kinetics and concentra…

Understanding Twitch Esports Communities through Livestream Chat Analysis

2022

2018

Celiac disease is a small intestinal inflammatory disease with autoimmune features that is triggered and maintained by the ingestion of the storage proteins (gluten) of wheat, barley, and rye. Prevalence of celiac disease is increased in patients with mono- and/or polyglandular autoimmunity and their relatives. We have reviewed the current and pertinent literature that addresses the close association between celiac disease and endocrine autoimmunity. The close relationship between celiac disease and glandular autoimmunity can be largely explained by sharing of a common genetic background. Further, between 10 and 30% of patients with celiac disease are thyroid and/or type 1 diabetes antibody…

Type 1 diabetes and polyglandular autoimmune syndrome: A review

2015

Type 1 diabetes (T1D) is an autoimmune disorder caused by inflammatory destruction of the pancreatic tissue. The etiopathogenesis and characteristics of the pathologic process of pancreatic destruction are well described. In addition, the putative susceptibility genes for T1D as a monoglandular disease and the relation to polyglandular autoimmune syndrome (PAS) have also been well explored. The incidence of T1D has steadily increased in most parts of the world, especially in industrialized nations. T1D is frequently associated with autoimmune endocrine and non-endocrine diseases and patients with T1D are at a higher risk for developing several glandular autoimmune diseases. Familial cluster…

Understanding the scaling-up of community energy niches through Strategic Niche Management Theory: insights from Finland

2018

The growing phenomenon of civil society involvement in renewable energy generation has attracted researchers’ interest. However, rather little is known of how a diverse and relatively small sector such as community energy could scale up and promote a change in energy production. We examine this issue through the lens of Strategic Niche Management (SNM) and conceptualize community energy as a socio-technical niche that holds the potential to promote a transition to renewable energy. Drawing on interview data with members of community energy projects and experts in Finland, we identify different types of community energy projects and the factors that may prevent them from scaling up. The stud…

Els parlars valencians

2018

En Scripta : revista internacional de literatura i cultura medieval i moderna = Scripta : International Journal of Medieval & Modern Literature & Culture. València : Universitat de València. Vol. 12 (desembre 2018), n. 12, pp. 254-258. Este artículo se encuentra disponible en la página web de la revista en la siguiente URL: https://ojs.uv.es/index.php/scripta/article/view/13659/12700

Aportaciones documentales sobre cruces de orfebrería valencianas. Siglos XIV y XV

2020

The article intends to make a contribution of new documentary references, from the notarial funds of the Valencian archives, in which news about parish crosses and Lignum Crucis from the silversmith center of Valencia during the fourteenth and fifteenth centuries are collected. The importance of these typologies lies in being the main elements of Christian worship, so it was an essential piece in each parish that allowed the provision in them of models of varied typology and functionality; for that reason they are conserved from altar crosses, cross-shaped reliquaries ?known as Lignum Crucis or Veracruz ?to processional crosses, larger and representative of the parish community to which it …

Du verbe instrumental dans la musique subsaharienne

2021

Sub-Saharan music results from the spoken language/instrumental language relation, directed by an oral culture. In this culture, these languages transmit ? beyond their singularities ? messages thanks to either a coded signal known by the linguistic community or previously defined among a group of individuals, or is used as a true meta-language copied on the articulated and usual language used every day. Here, an instrumental musical speech can then imitate and reproduce the tonal inflexions of the language to make its matter understandable. This fact is the natural result of a strong interaction and interrelation between the spoken language and the music as well as the conception that the …

Moderating the Effects of Corruption on Community Development through Transparent Governance : A Case Study of Nando and Aguleri Community in Anambra…

2018

Master's thesis Global development and planning UT505 - University of Agder 2018 This study investigates public perception of corruption and its effects on the development of Nando and Aguleri community in Anambra East local government area of Anambra State Nigeria. The main aim has been to understand the local people’s perception on the effects of corruption on community development and whether transparent governance can moderate the identified effects. Purposive sampling was used to sample participants from five categories of group in the community over their experience to the research topic. I utilized qualitative research strategy, using mainly semi-structured interviews, focus group di…