Search results for "Unity"
showing 10 items of 3852 documents
Neuroprotection and autoimmunity in glaucoma
2012
In glaucoma, the elevated intraocular pressure cannot explain the disease in all patients. However, the pathogenesis of the disease is widely unknown. Biomarker research could be help to understand the disease process. Beside some genetic and proteomic biomarkers, immunoproteomics could play a significant role. Several studies could provide hints for an involvement of autoantibodies in the pathogenesis of the disease. The complex profiles of natural occurring autoantibodies were analyzed by Western Blotting and mass spectrometry based techniques combined with multivariate statistics and artificial neural networks. In several studies we could demonstrate consistent up- and down-regulations o…
Cellul�re Immunreaktionen gegen�ber homologen leberspezifischen Antigenen (HLP) bei chronischen Leberentz�ndungen
1974
Es wird eine Zweiphasentechnik des Leukocyten-Migrations-Inhibitionstestes beschrieben und zum Nachweis einer cellularen Immunreaktion gegenuber Leberantigenen bei chronisch-entzundlichen Lebererkrankungen eingesetzt. Mit dieser Technik wurde bei 85% der Patienten mit hypergammaglobulinamischer Verlaufsform einer chronisch-aktiven Hepatitis und 42% der Patienten mit aktiv fortschreitenden kryptogenen Lebercirrhosen eine Migrationshemmung nachgewiesen. Lebergesunde Kontrollen zeigten keine, Patienten mit dem Zustand nach Hepatitis und chronisch-persistierender Hepatitis selten eine Leukocytenmigrationsinhibition gegenuber leberspezifischen Antigenen. 17% der Patienten mit chronisch-aktiver H…
Optimizing the Use of an Integrated LMS: Hardware Evolution through Distributed Computing. Experience from the Universitat de València
2009
The advent of the Internet has opened a scope for research in new methods and tools that may facilitate the teaching and learning processes. This has, in turn, led to the development of learning platforms to support teaching and learning activities. Nowadays most universities provide their academic community with some form of a learning management system (LMS). To achieve the optimal use of such type of systems, they must integrate all their academic community and preexisting applications at its institutions. These complex objectives can be reached by using a robust architecture, preferably an open system, based on distributed computing. In this paper, we expose the Universitat de Valencia …
Sports and Community Well-Being
2017
This chapter explores the relationship between sports and community well-being, taking into account factors such as social bonds, social and cultural integration, health, improved quality of life, and the enhancement of personal and community well-being. Well-being is a concept with a long history and development. Originally used in the field of philosophy, it then spread to psychology. Community well-being is a relatively recent, little-explored term, which builds on the concepts of well-being and quality of life. This chapter provides a theoretical assessment based on the concepts of well-being, community well-being, and sports, distinguishing the latter from mere physical activity. Final…
Encuesta sobre hábitos higiénicos orales en la población adolescente de la Comunidad Valenciana (2004)
2006
espanolIntroduccion: (fundamento y objetivo): Coincidiendo con el estudio epidemiologico de la Comunidad Valenciana 2004, se ha realizado una encuesta de habitos para valorar la evolucion en el periodo 1998-2004. Pacientes y metodo: La encuesta fue contestada por una muestra seleccionada al azar de 478 escolares de 12 anos y 401 de 15-16 anos. Resultados: El cepillado diario mas de una vez al dia fue realizado por el 52,3% de los ninos y una vez al dia por el 27,3%. Un 3% no se cepilla nunca y un 15,7% lo hace de vez en cuando. Un 51,4% ha ido al dentista en los ultimos seis meses, un 20,1% lo hizo entre los seis meses y el ano, y el 7,6% no ha ido nunca al dentista. El 56,7% ha hecho enjua…
New glucocorticoids. Mechanisms of immunological activity at the cellular level and in the clinical setting.
1990
Modeling a Complex Disease
2011
The recent decades have shown that multiple sclerosis (MS) is not a uniform disease entity with common etiology, but rather a disease or syndrome characterized by a heterogeneous pattern of manifestations and pathological principles. Apart from the older distinctions of the Devic's disease from the standard Western form of relapsing remitting MS or the more Asian form of opticospinal MS, specific pathological patterns indicating distinct etiologies have been established by analyses of biopsies and autopsies. Further, the distinct responses of patients to drugs targeting either specific cell types or immunoregulatory mechanisms such as Rituximab or IFNβ clearly demonstrate the heterogeneity …
Heat Shock Proteins in Multiple Sclerosis Pathogenesis: Friend or Foe?
2015
Multiple Sclerosis is a complex chronic inflammatory, neurodegenerative disease conditioned by genetic, epigenetic and environmental factors. Main pathological features of MS include areas of focal demyelination of white matter characterized by gliosis, neuron and oligodendrocyte loss. Neurodegenerative as well as immune-mediated processes play a role in the pathogenesis of this disease. One of these immunogenic factors could be represented by the heat shock proteins. HSP exhibit cytoprotective and cytostimulatory effects due to their molecular chaperones role, in many brain model misfolding diseases such as Alzheimer’s and Parkinson’s diseases, whereas still no unambiguous results have bee…
NF-κB in inflammatory bowel disease
2008
Apart from genetic and environmental factors, the mucosal immune system of the gut plays a central role in the pathogenesis of inflammatory bowel disease (IBD). In the healthy gut, the mucosal immune system ensures the balance between pro- and anti-inflammatory mediators and thereby allows an effective defence against luminal pathogens but at the same time prevents an overwhelming immune reaction directed against the huge amount of harmless luminal antigens (for example, components of food or nonpathological bacteria). In both entities of IBD (Crohn's disease and ulcerative colitis) this immunological balance is severely impaired and shifted towards the pro-inflammatory side. The chronic mu…