Search results for "Unity"
showing 10 items of 3852 documents
The interplay between the host microbiome and pathogenic viral infections
2021
The microorganisms associated with an organism, the microbiome, have a strong and wide impact in their host biology. In particular, the microbiome modulates both the host defense responses and immunity, thus influencing the fate of infections by pathogens. Indeed, this immune modulation and/or interaction with pathogenic viruses can be essential to define the outcome of viral infections. Understanding the interplay between the microbiome and pathogenic viruses opens future venues to fight viral infections and enhance the efficacy of antiviral therapies. An increasing number of researchers are focusing on microbiome-virus interactions, studying diverse combinations of microbial communities, …
Human Papillomavirus Type 16 E7 Peptide-Directed CD8+ T Cells from Patients with Cervical Cancer Are Cross-Reactive with the Coronavirus NS2 Protein
2003
ABSTRACTHuman papillomavirus type 16 (HPV16) E6 and E7 oncoproteins are required for cellular transformation and represent candidate targets for HPV-specific and major histocompatibility complex class I-restricted CD8+-T-cell responses in patients with cervical cancer. Recent evidence suggests that cross-reactivity represents the inherent nature of the T-cell repertoire. We identified HLA-A2 binding HPV16 E7 variant peptides from human, bacterial, or viral origin which are able to drive CD8+-T-cell responses directed against wild-type HPV16 E7 amino acid 11 to 19/20 (E711-19/20) epitope YMLDLQPET(T) in vitro. CD8+T cells reacting to the HLA-A2-presented peptide from HPV16 E711-19(20)recogni…
Immune responses during COVID-19 infection
2020
International audience; Over the past 16 years, three coronaviruses (CoVs), severe acute respiratory syndrome CoV (SARS-CoV) in 2002, Middle East respiratory syndrome CoV (MERS-CoV) in 2012 and 2015, and SARS-CoV-2 in 2020, have been causing severe and fatal human epidemics. The unpredictability of coronavirus disease-19 (COVID-19) poses a major burden on health care and economic systems across the world. This is caused by the paucity of in-depth knowledge of the risk factors for severe COVID-19, insufficient diagnostic tools for the detection of SARS-CoV-2, as well as the absence of specific and effective drug treatments. While protective humoral and cellular immune responses are usually m…
Citizen Response in Crisis : Individual and Collective Efforts to Enchance Community Resilience
2014
This paper reports on the process and findings of an extensive research project with the aim of investigating present initiatives and approaches within the area of community resilience and citizen involvement. The paper specifically addresses which emerging sociotechnical approaches can be discerned within these initiatives. The discussion is structured within three categories of potential voluntary engagement; organized volunteers, semiorganized individuals, and “nonorganized” individuals. The empirical material assembled in the research project is contrasted with contemporary international research literature regarding sociotechnical means for enhancing community resilience. Swedish appro…
Identity construction in the comments section of TomandLorenzo.com
2016
Virtual spaces as sites of social interactions and therefore identity work have become common over the past few decades. Alongside, research focus on such spaces has increased. This MA thesis constitutes a small contribution to the study of interactional identity building through computer mediated communication. The study was conducted on data gathered from a subsection of popular-culture blog tomandlorenzo. The aim was to identify how interactants in this space interactively work their identities. The qualitative discourse analysis focused on three mechanics of identity building, those of indexicality, performativity and stance taking. The investigation also took the influence of the mediu…
Mapping the Concept(s) of Belonging
2014
Various epistemological changes – such as the linguistic, narrative, and cultural turns that have influenced humanistic and social scientific studies since the 1980s – have contributed to the increased academic interest in politics, discourses, processes, and practices of belonging. During the recent decades, the idea of belonging or notbelonging have been discussed and theorized in various fields with diverse parallel and/or overlapping conceptualizations. These include, for example, identity, placemaking, displacement, and their representational, intersectional, and fluid nature. In recent years, several scholars have aimed to discuss the topics framed by the above mentioned concepts and …
Interaction rituals in parenthood discussion forum RaisingKids.co.uk : entering rituals, rants and prayer requests
2006
Finnish in Toronto: Students and elderly immigrants in a community engaged service learning project
2019
Kuvaamme artikkelissamme yhteisössä toteutettavaa palveluoppimispedagogiikkaa (community engaged service learning pedagogy) Toronton yliopiston suomen kielen ohjelman ja Toronton Suomi-kodin eli suomenkielisen seniorikeskuksen välillä. Osana suomi vieraana kielenä -kurssia opiskelijat vierailevat säännöllisesti Suomi-kodissa, osallistuvat sen toimintaan ja viettävät aikaa suomenkielisten senioreiden parissa. Tutkimme sitä, mitä siirtolaissenioripari (Sirkka ja Pentti) ja kaksi nuorta suomen kielen opiskelijaa (Rosa ja Ilja) ajattelevat ja puhuvat kielestä ja sen oppimisesta erilaisissa kohtaamisissa. Lisäksi pohdimme sitä, millaisia siltoja yhteistyö muodostaa senioreiden ja nuorten väli…
Sysmä Community Currency: An Analysis of its Success from the Perspectives of Purposes, Stakeholders and Promotion
2019
Artikkeli on tapaustutkimus paikallisrahajärjestelmästä, jota kokeiltiin äskettäin maalaisympäristössä Sysmän kunnassa. Paikallisraha on yksi innovaatiivisista aloitteista, joita kunta on tehnyt tällä vuosituhannella torjuakseen jo 1960-luvulta alkaen käynnissä ollutta väestökatoa. Tässä artikkelissa tutkitaan paikallisrahan käynnistysvaihetta siihen sisältyneiden ristiriitojen näkökulmasta. Artikkelissa todetaan, että järjestelmä kärsi epäselvästä tavoitteenasettelusta, ja että eri osallisilla oli tavoittesta vaihtelevia ja ristiriitaisia käsityksiä. Paikallisrahan sosiaalista hyväksyntää heikensivät päätös rajoittaa rahaa vastaanottavien yritysten joukko kunnassa kirjoilla oleviin yrityks…
The impact of consumer local engagement on local store patronage and customer satisfaction
2017
This paper examines the drivers of local grocery retail patronage. Drawing on institutional and social network theory literature, we develop a framework to investigate how consumers’ personal values and engagement with local communities affect their satisfaction and local store patronage. We test our model with survey data on 1504 Finnish consumers. Our results show that the relationship between customer local engagement and local retail patronage is indirect rather than direct, and it is mediated by the vitality of local services, social interaction, and consumer satisfaction.